Abstract Background Neuropathic pain (NP) is a debilitating condition caused by lesion or dysfunction in the somatosensory nervous system. Accumulation of advanced oxidation protein products (AOPPs) implicated mechanical hyperalgesia. However, effects AOPPs on NP remain unclear. Methods A rat model was established chronic constriction injury (CCI) and employed to evaluate changes withdrawal threshold, thermal cold latency, as well levels. The activation satellite glial cells (SGCs) dorsal...

The real-time, accurate, and refined monitoring of urban green space status information is great significance in the construction ecological environment improvement benefits. high-resolution technology can provide abundant ground objects, which makes surface more complicated. existing classification methods are challenging to meet accuracy automation requirements images. This paper proposed a deep learning method for based on phenological features constraints order make full use spectral...

ABSTRACT Preclinical Research The objective of this study was to formulate a self‐nanoemulsifying oral drug delivery system (SNEDDS) for the poorly water‐soluble trans ‐Cinnamic acid ( t ‐CA SNEDDS) that could be evaluated its antihyperglycemic efficacy in comparison parent an alloxan‐induced diabetic rat model. A SNEDDS formulation consisting 60% surfactant (Kolliphor EL), 10% co‐surfactant (PEG 400) and 30% oil (isopropyl myristate) proved optimal. (80 mg/kg, p.o.), suspension Metformin...

In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating expression levels of TfR1 and DMT1 exacerbated migration triple-negative breast cancer cells. However, mechanisms distribution utilization in cells with a DFO-induced deficiency are still unclear. this MDA-MB-231 estrogen receptor (ER)-positive MCF-7 were used to investigate deficiency. We found that mitochondrial was elevated cells, while it decreased after DFO treatment. The cellular reactive oxygen...

Recent studies suggest that highly activated, polyfunctional CD4+ T cells are incredibly effective in strengthening and sustaining overall host antitumor immunity, promoting tumor-specific T-cell responses effectively enhancing immunity by immunotherapy. Previously, we developed a novel cryo-thermal therapy for local tumor ablation achieved long-term survival rates several models. It was discovered remodeled the microenvironment induced an antigen-specific response, which mediated stronger...

Myeloid-derived suppressor cells (MDSCs) can potently inhibit T-cell activity, promote growth and metastasis of tumor contribute to resistance immunotherapy. Targeting MDSCs alleviate their protumor functions immunosuppressive activities is intimately associated with cancer Natural killer (NK) engage in crosstalk multiple myeloid alter adaptive immune responses, triggering immunity. However, whether the NK-cell-MDSC interaction modulate response requires further study. Cryo-thermal therapy...

Macrophages play critical roles in both innate and adaptive immunity are known for their high plasticity response to various external signals. involved regulating systematic iron homeostasis they sequester by phagocytotic activity, which triggers M1 macrophage polarization typically exerts antitumor effects. We previously developed a novel cryo-thermal therapy that can induce the mass release of tumor antigens damage-associated molecular patterns (DAMPs), promoting polarization. However,...

The purpose of this study is to reveal the clinicopathological features and identify risk factors prognosis among patients with pancreatic cancer bone metastasis (PCBM).Patients PCBM were retrieved from Surveillance, Epidemiology, End Results (SEER) database between 2010 2016. Independent predictors for survival those determined by univariate multivariate Cox regression analysis. Forest plots drawn GraphPad 8.0.1 used visually display results analysis.We identified 2072 eligible patients,...

Targeting myeloid-derived suppressive cells (MDSCs) has been considered a potential strategy in tumor therapy. However, single drug targeting MDSCs remains challenge the clinic. An increasing number of studies have shown that combination agents and immunotherapy may provide exciting new insights avenues to explore In our previous study, novel cryo-thermal therapy was developed for metastatic tumors systematically activate innate adaptive immunity. Moreover, dramatically decrease levels...

Abstract Non-small cell lung cancer (NSCLC) is known for rapid development and chronic inflammation-induced immunosuppression. IL-6 IL-17A are the essential cytokines that facilitate NSCLC progression myeloid-derived suppressive (MDSC)-mediated evasion. or targeting, especially IL-6, shown outstanding efficacy in patient controlling, but failed to completely eradicate tumor. The local tumor multi-mode thermal therapy developed our prior research was demonstrated stimulate systemic durable...

The aim of the present study was to compare clinical and economic benefits intra‑articular injections platelet‑rich plasma (PRP) hyaluronic acid (HA) in Chinese patients with knee osteoarthritis (OA). A total 86 (42 treated PRP 44 HA) were three weekly injections. inclusion criteria included between 18 75 years age, chronic pain or swelling lasting >3 months X‑ray findings degenerative joint alterations according Kellgren‑Lawrence score grade I‑III. Clinical examinations performed before...

Immunotherapy has emerged as a therapeutic pillar in tumor treatment, but only minority of patients get benefit. Overcoming the limitations immunosuppressive environment is effective for immunotherapy. Moreover, host T cell activation and longevity within are required long-term efficacy. In our previous study, novel cryo-thermal therapy was developed to improve survival B16F10 melanoma s.q. 4T1 breast cancer mouse models. We determined that induced Th1-dominant CD4+ differentiation...

Immunosuppression plays a significant role in tumor recurrence and metastasis, ultimately causing poor survival outcomes. Overcoming immunosuppression stimulating durable antitumor immunity are essential for treatment. In our previous study, novel cryo-thermal therapy involving liquid nitrogen freezing radiofrequency heating could reduce the proportion of Myeloid-derived suppressor cells (MDSCs), but remaining MDSCs produced IL-6 by NF-κB pathway, resulting an impaired therapeutic effect....

Microplastics are plastic particles with a diameter of less than 5 mm that originate from human activities and widely present in marine environments, resulting serious impacts on organisms ecosystems. In this study, 10 sampling sites were set the tidal flats Sanya Bay based functional depth differences. The samples collected using coring method then statistically analyzed stereo microscope. spatial distribution, size range, color , shape characteristics microplastics pollution level...

Sparse regression methods based on the spectral libraries have shown promise for hyperspectral unmixing, which assumes that observed image can be represented linearly by a small subset of known library. However, mismatches are often assumed to occur between actual endmembers and corresponding signatures in library, greatly limits application sparse unmixing method. In this article, we address abovementioned problem adaptively adjusting library match current during procedure propose adaptive...

Purpose Gastrointestinal neuroendocrine carcinoma (NEC) with bone metastasis is rarely reported. The purpose of this study to explore the prognosis and risk factors such patients. Patients Methods We retrospectively reviewed patients diagnosed as gastrointestinal NECs at diagnosis from 2010 2016 by using Surveillance, Epidemiology End Results (SEER) database. Predictors overall survival (OS) cancer-specific (CSS) were analyzed univariable multivariable Cox analyses. Kaplan–Meier plots...

The characteristics of the tumor immunosuppressive microenvironment represent a major challenge that limits efficacy immunotherapy. Our previous results suggested cryo-thermal therapy, ablation system developed in our laboratory, promotes macrophage M1-type polarization and complete maturation DCs to remodel environment. However, cells respond promptly CTT have not yet been identified. can cause extensive cell death release danger-associated molecular patterns antigens. Neutrophils are first...

Abstract Background Postoperative residual knee pain after total arthroplasty (TKA) is a significant factor that contributes to patient dissatisfaction. Patients with preoperative central sensitization (CS) may be more susceptible unexplained chronic TKA, and duloxetine has been reported effective in post-TKA control patients CS. However, there remains limited evidence support this off-label use routine clinical practice. Hence, we designed randomized, placebo-controlled, triple-blind trial...

Effective cancer therapies should reshape immunosuppression and trigger antitumor immunity. Previously, we developed a novel cryo-thermal therapy through applying local rapid cooling followed by heating of tumor tissue. It could not only ablate tumors, but also, subsequently, induce systemic long-term Hyperthermia can the release extracellular vesicles (EVs) to stimulate We examine whether EVs are released after they improve efficacy in 4T1 model. In this study, serum (sEVs) isolated...