A5065832011- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Advancements in Transdermal Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Curcumin's Biomedical Applications
- Nerve injury and regeneration
- Polysaccharides and Plant Cell Walls
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Polysaccharides Composition and Applications
- Quantum Dots Synthesis And Properties
- Drug Transport and Resistance Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Bioactive Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Electrospun Nanofibers in Biomedical Applications
- Advanced battery technologies research
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
Jiangsu University
2016-2025
Tianjin University of Technology
2024
Suzhou University of Science and Technology
2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Hunan Normal University
2024
Zunyi Medical University
2016-2023
Zhanjiang Experimental Station
2017-2019
Hunan University
2017
Sichuan University
2011-2013
With the increasing demand for higher gene carrier performance, a multifunctional vector could immensely simplify delivery disease treatment; nevertheless, current non- viral vectors lack self-tracking ability. Here, type of novel, dual-functional cationic carbon dots (CDs), produced through one-step, microwave-assisted pyrolysis arginine and glucose, have been utilized as both self-imaging agent non-viral chondrogenesis from fibroblasts. The CDs condense model plasmid SOX9 (pSOX9) to form...
Abstract Plant‐derived exosomes (PEs) possess an array of therapeutic properties, including antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive responses to pathogenic attacks. Spinal cord injuries (SCIs) regeneration represents a global medical challenge, with appropriate research concentration on three pivotal domains: neural promotion, inflammation inhibition, innovation application regenerative scaffolds. Unfortunately, the utilization PE SCI...
Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency MSCs derived chorionic plate (CP-MSCs) for premature failure (POF).We investigated restorative effects CP-MSCs on cyclophosphamide (CTX)-induced POF. The POF mouse models were established via intraperitoneal injection 50 mg/kg CTX into female mice 15 consecutive days. After that,...
Capsaicin, as a food additive, has attracted worldwide concern owing to its pungency and multiple pharmacological effects. However, poor water solubility low bioavailability have limited application. This study aims develop capsaicin-loaded microemulsion enhance the oral of anti-neuropathic-pain component, capsaicin, which is poorly soluble.In this study, consisting Cremophor EL, ethanol, medium-chain triglycerides (oil phase) (external was prepared characterized (particle size, morphology,...
Multifunctional CDs co-deliver transcription factors for neuronal differentiation of EMSCs the first time.
Abstract The therapeutic efficiency of allogenic/intrinsic neural stem cells (NSCs) after spinal cord injury is severely compromised because the hostile niche at lesion site incurs massive astroglial but not neuronal differentiation NSCs. Although many attempts are made to reconstruct a permissive for nerve regeneration, solely using living cell material build an all‐in‐one, multifunctional, promoting while inhibiting NSCs reported. Here, ectomesenchymal (EMSCs) reported serve as living,...
ABSTRACT Preclinical Research The objective of this study was to formulate a self‐nanoemulsifying oral drug delivery system (SNEDDS) for the poorly water‐soluble trans ‐Cinnamic acid ( t ‐CA SNEDDS) that could be evaluated its antihyperglycemic efficacy in comparison parent an alloxan‐induced diabetic rat model. A SNEDDS formulation consisting 60% surfactant (Kolliphor EL), 10% co‐surfactant (PEG 400) and 30% oil (isopropyl myristate) proved optimal. (80 mg/kg, p.o.), suspension Metformin...
Due to the obstruction and heterogeneity of blood-brain barrier, clinical treatment glioma has been extremely difficult. Isoliquiritigenin (ISL) exhibits antitumor effects, but its low solubility bioavailability limit application potential. Herein, we established a nanoscale hybrid membrane-derived system composed erythrocytes tumor cells. By encapsulating ISL in membrane nanoparticles, is expected be enhanced for targeting long-circulation gliomas therapy. We fused with human cells U251...
Ectomesenchymal stem cells (EMSCs) are typical adult obtained from the cranial neural crest. They have potential to differentiate into various cell types, such as osseous cells, neurons and glial cells. Three-dimensional (3 D) printing is a novel method construct biological structures by rapid prototyping. Previously, our group reported on stemness multi-lineage differentiation of EMSCs gels. However, exploration in 3 D then evaluation growth neuronal extruded printable hybrid hydrogels has...
Abstract Generating of induced pluripotent stem cells (iPSCs) can be achieved by ectopic expression defined transcription factor sets. However, most instances iPSC induction have been using viral vectors, which carry the risk unpredictable genetic dysfunction. Here, for first time, a non‐viral vector based on calcium phosphate nanoparticles generation virus‐free iPSCs from human umbilical cord mesenchymal (HUMSCs) via co‐delivery four plasmids (Oct4, Sox2, Klf4, and c‐Myc) is reported. As...