A5009369904- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Spinal Dysraphism and Malformations
- Ultrasound and Hyperthermia Applications
- Pelvic and Acetabular Injuries
- Pregnancy-related medical research
- Spinal Cord Injury Research
- Healthcare and Venom Research
- Mesenchymal stem cell research
- Pain Mechanisms and Treatments
- Spinal Hematomas and Complications
- Bone Metabolism and Diseases
- Anesthesia and Pain Management
- Cerebrospinal fluid and hydrocephalus
- Nerve injury and regeneration
- Bone health and treatments
- Genomic variations and chromosomal abnormalities
- Advanced Neuroimaging Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Thyroid Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Neuropeptides and Animal Physiology
Second Military Medical University
2015-2024
Shanghai Changzheng Hospital
2017-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Jiangsu University
2011-2023
Changhai Hospital
2015-2017
Shanghai Municipal Education Commission
2017
Bridge University
2015
Yahoo (United Kingdom)
2014
Although anterior and posterior decompression surgery are both reported to treat patients with myelopathy caused by ossification of the longitudinal ligament (OPLL). The surgical strategy disease is still controversial when OPLL multilevel severe. This present study reports preliminary clinical results a novel technique named controllable antidisplacement fusion (ACAF) for treatment multilevel-severe myelopathy. A series 15 cervical compression severe were enrolled. All underwent ACAF after...
Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis). However, recent analyses neovascularization are very complicated, and the mechanism action rarely reported.Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) was performed analyze human nonherniated pulposus. Then, clinical relevance MALDI-TOF MS results Pfirrmann...
Due to the obstruction and heterogeneity of blood-brain barrier, clinical treatment glioma has been extremely difficult. Isoliquiritigenin (ISL) exhibits antitumor effects, but its low solubility bioavailability limit application potential. Herein, we established a nanoscale hybrid membrane-derived system composed erythrocytes tumor cells. By encapsulating ISL in membrane nanoparticles, is expected be enhanced for targeting long-circulation gliomas therapy. We fused with human cells U251...
The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect development various diseases. However, relationship between reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal in nucleus pulposus (NPCs) during IVDD investigate mechanism glycolysis-derived lactate on NPCs. Single-cell RNA sequencing reveals IVDD, NPCs are characterized excessively elevated glycolysis, resultant causes...
Low back pain (LBP) has been a wide public health concern worldwide. Among the pathogenic factors, intervertebral disc degeneration (IDD) one of primary contributors to LBP. IDD correlates closely with inflammatory response and oxidative stress, involving variety inflammation‐related cytokines, such as interleukin 1 beta (IL‐1 β ), which could result in local environment. Ulinastatin (UTI) is kind acidic protein extracted from human urine, inhibits release tumor necrosis factor alpha (TNF‐ α...
Abstract Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate spinal fusion. Type H microvessels are in close relation with bone development. We analyzed the role of type vessels rat fusion model intervened by LIPUS. It was LIPUS could significantly rate and enlarge callus. Osteoblasts were specifically located on meshwork allograft surrounded microvessels. increase quantity osteoblasts during spine fusion, which process coupled elevated angiogenesis Our results suggest that...
Lumbar intervertebral disc degeneration (IDD) has been the major contributor to low back pain (LBP). IDD is an chronic inflammation process, with activation of plentiful inflammation‐related cytokines and ECM degradation‐related enzymes. In past few years, hypertension reported correlate LBP. addition, local tissue renin‐angiotensin system (tRAS) identified in multiple tissues, including spinal cord, skin, kidney, heart, bone. Recently, tRAS also established both bovine human especially...
This study investigates the use of a natural polysaccharide isolated from mulberry leaves as nonviral gene vector. Ethylenediamine is chemically grafted to backbone (MPS) acquire nucleic acid binding affinity. A particle-size observation indicates that cationic leaf (CMPS) can efficiently combine with plasmid transforming growth factor β1 (TGF-β1) form nanoscaled particles. In addition, electrophoresis assay retarded migration when CMPS/pTGF-β1 weight ratio increased 30:1. The in vitro cell...
Selective fusion of the thoracolumbar/lumbar (TL/L) curve is an effective method for treatment Lenke type 5C curves. Several studies have demonstrated that spontaneous correction thoracic does indeed occur. However, how this occurs after isolated posterior segmental instrumentation structural lumbar has not been well described. The aim study was to evaluate response selective TL/L in patients with adolescent idiopathic scoliosis (AIS) and assess correlative clinical outcomes. Thirty-four...
Intervertebral disc degeneration (IDD) is characterized by excessive inflammatory reaction, and neuropeptide Y (NPY) was reported to have anti-inflammatory effect. However, the effect of NPY on NP cells has not been investigated up date. This study aimed clarify role process IDD. Fourteen fresh human lumbar intervertebral discs were harvested, degeneration-related proteins examined. Pfirrmann grading system used evaluate Rat nucleus pulposus (NP) investigate proliferation, apoptosis,...
Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous studies have demonstrated that oxidative stress inflammation-induced senescence apoptosis nucleus pulposus cells (NPCs) are main cellular processes IDD. Arginase II (ARG2), an enzyme involved in a variety pathological processes, including senescence, apoptosis, stress, inflammation, shown to promote several...
Background: Prophylactic central lymph node dissection (CLND) in papillary thyroid microcarcinoma (PTMC) patients without clinical evidence of metastasis (CLNM) remains controversial. The purpose our study is to identify preoperative predictive factors for finding CLNM Chinese PTMC patients, which may allow tailored CLND. Methods: We retrospectively reviewed 182 consecutive PMTC with negative nodes who underwent total thyroidectomy plus neck from October 2015 December 2017. Chi-squared and...
Congenital vertebral malformations (CVMs) manifest with abnormal morphology. Genetic factors have been implicated in CVM pathogenesis, but the underlying pathogenic mechanisms remain unclear most subjects. We previously reported that human 16p11.2 BP4-BP5 deletion and its associated
Objective For precise and minimally invasive treatment of ossification the posterior longitudinal ligament cervical spine, lifting segment is minimized, anterior controllable antedisplacement fusion (ACAF) was refined improved. In addition, development appropriate surgical procedures for each rarely reported. Therefore, this study aimed to compare efficacy safety hybrid controlled (Hybrid ACAF) with laminoplasty multilevel (OPLL). Methods Between May 2018 2021, 70 patients OPLL were divided...
Study Design. A retrospective clinical and radiographic study. Objective. The aim of this study was to analyze the change in cervical sagittal alignment (CSA) identify possible factors influencing postoperative CSA selective posterior thoracolumbar/lumbar (TL/L) curve correction. Summary Background Data. correlation between thoracic (TSA) is a well-recognized phenomenon patients with idiopathic scoliosis. However, little has been published about influence TL/L instrumentation on CSA....
The Oxford Shoulder Score (OSS) is a reliable and valid construct measuring non-specific shoulder pain, which are widely used to evaluate related quality of life. This study was cross-culturally adapt psychometrically validate simplified Chinese version the OSS (SC-OSS). Cross-cultural adaptation performed according international recognized guidelines. Consecutive patients with nonspecific pain were recruited test psychometric properties SC-OSS. Item response trend item-total correlation...