A5100453146- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Chromatography in Natural Products
- Ginger and Zingiberaceae research
- Piperaceae Chemical and Biological Studies
- Phytochemistry and Bioactivity Studies
- Histone Deacetylase Inhibitors Research
- Gut microbiota and health
- Chemical Reactions and Isotopes
- Advanced Drug Delivery Systems
- Hepatitis C virus research
- Syphilis Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Protein Interaction Studies and Fluorescence Analysis
- Medicinal Plants and Neuroprotection
- Hepatitis B Virus Studies
- Atrial Fibrillation Management and Outcomes
- Estrogen and related hormone effects
- Flavonoids in Medical Research
- Fatty Acid Research and Health
- Advancements in Transdermal Drug Delivery
Zhejiang Cancer Hospital
2025
Chinese Academy of Sciences
2025
Zhejiang Center for Disease Control and Prevention
2025
State Ethnic Affairs Commission
2024
Soochow University
2024
Guiyang Medical University
2019-2024
Affiliated Hospital of Guizhou Medical University
2019-2024
Jinzhou Medical University
2024
Minzu University of China
2024
Peking University People's Hospital
2024
Bergenin, a rare C-glycoside of 4-O-methyl gallic acid with pharmacological properties antitussive and expectorant, is widely used in clinics to treat chronic tracheitis China. However, its low abundance nature structural specificity hampers the accessibility through traditional crop-based manufacturing or chemical synthesis. In present work, we elucidate biosynthetic pathway bergenin Ardisia japonica by identifying highly regio- and/or stereoselective 2-C-glycosyltransferases...
Due to the obstruction and heterogeneity of blood-brain barrier, clinical treatment glioma has been extremely difficult. Isoliquiritigenin (ISL) exhibits antitumor effects, but its low solubility bioavailability limit application potential. Herein, we established a nanoscale hybrid membrane-derived system composed erythrocytes tumor cells. By encapsulating ISL in membrane nanoparticles, is expected be enhanced for targeting long-circulation gliomas therapy. We fused with human cells U251...
Intestinal barrier dysfunction is inflammatory bowel disease's hallmark. Berberine (BBR) has manifested its anti-inflammatory properties in colitis. For exploring the molecular mechanism of BBR's impacts on colitis, application a dextran sodium sulfate-induced mouse colitis vivo model was with recording body weight, stool consistency, occult blood and general physical symptoms all groups mice every day. Behind assessment intestinal permeability, detection colon damage's degree apoptosis,...
Background: Persistent infections caused by Helicobacter pylori ( H. ), which are resistant to antibiotic treatment, pose a growing global public health concern. Biofilm formation is known be associated with persistent due its role in enhancing antimicrobial resistance and the tolerance of many pathogenic bacteria. Objective: This study aims evaluate biofilm clinical isolates impact on eradication. Methods: The thickness, morphology, structure biofilms derived from nine strains were examined...
Purpose: Various microRNAs are involved in the development of gastric cancer (GC). This study investigated role and mechanism miR-520a-3p GC. Method: Quantitative real-time fluorescence PCR (qRT-PCR) was applied to measure expression level GC tissues cell lines. The chi-squared test employed evaluate relationship between miR-520a-30p clinical traits. count kit-8 assay used detect effect on proliferation, while its glycolysis determined using glucose assumption, lactate, ATP production assay....
Purpose Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD), which has a high risk cirrhosis, failure, and hepatocellular carcinoma. Piperine (Pip) an extract plants with powerful anti-inflammatory effects, however, function Pip in NASH remains elusive. Here, we aim to explore role find possible mechanisms. Methods Methionine choline-deficient (MCD) diets were used induce steatohepatitis, methionine- choline-sufficient (MCS) as control....
Invasive fungal infections (IFI) are frequent complications of allogeneic hematopoietic stem cell transplantation (SCT) and major causes a poor prognosis. Analysis risk factors prognosis IFI important for the control IFI.We retrospectively reviewed medical records all SCT recipients from January 2000 to December 2007. For homogeneity analysis, only 286 patients with no history were included.Fifty-five cases identified, corresponding cumulative incidence 19.8%. Different overall survival...
The development and identification of novel potential targeting sites for intervention therapy are essential in the search improved treatment methods gastric cancer (GC). Previously, it has been reported that hypoxia inducible factor-1α (HIF-1α) is a target gene involved endogenous hypoxic response bioenergetic metabolism GC cells. In present study, with assumption close interplay among HIF-1α, glucose transporter 1 (GLUT1) lactate dehydrogenase-5 (LDH-5), 85 patients were recruited protein...
Colorectal cancer (CRC) ranks second in cancer-associated mortality and third the incidence worldwide. Most of CRC follow adenoma-carcinoma sequence, have more than 90% chance survival if diagnosed at early stage. But recommended screening by colonoscopy is invasive, expensive, poorly adhered to. Recently, several studies reported that fecal bacteria might provide non-invasive biomarkers for precancerous tumors. Therefore, we collected uniformly re-analyzed these published 16S rDNA...
Facial skin exhibits unique biophysical properties, which are influenced by anatomical regions and genders. The aim of this study was to comprehensively assess the regional gender differences in facial parameters among Chinese population.The 12 at four distinct sites (forehead, cheek, canthus chin) were measured a normal population (n = 212) with 42 males 141 females aged 18-29 years living Beijing. These consisted hydration, transepidermal water loss, sebum content, erythema/melanin...
In order to develop a promising carrier for the oral delivery of proteins and peptide drugs, novel bioadhesive nanocarrier chitosan (CTS) derivatives coated with poly (n-butyl) cyanoacrylate nanoparticles (PBCA-NPs) was prepared in this study.Three different thymopentin (TP5)-loaded were present study. TP5-PBCA-NPs developed by modifying an emulsion polymerization method, CTS chitosan-glutathione (CG) derivative-coated PBCA obtained from electrostatic interactions between or CG negatively...
After a SAR study of santacruzamate A, <bold>5</bold> was discovered to selectively inhibit the growth malignant cancer cells.
Objective To explore potential mechanisms and effects of gallincin on a mouse model colitis induced by dextran sulfate sodium (DSS). Methods Network pharmacology analysis was used to predict the molecular mechanism action for treatment colitis. Gallincin administered orally mice with DSS-induced Expression tumor necrosis factor α (TNF-α), D-lactate, interleukin-1β (IL-1β) myeloperoxidase activity were assessed real-time quantitative PCR an enzyme-linked immunoassay, respectively. occludin,...
Gastric syphilis is a rare manifestation of that occurs in about 1% cases and often overlooked due to its non-specific signs symptoms. We report case 28-year-old Chinese woman who presented with epigastric pain, nausea, vomiting, hematemesis, alopecia, weight loss. She tested positive for Helicobacter pylori (H. pylori), rapid plasma reagin (RPR) Treponema pallidum particle assay (TPPA) tests showing titers 1:128 1:320, respectively. CT imaging revealed thickening the gastric wall, exudation...
1. Triacontanol was confirmed to have a potential anti-cancer effect, the aim assess whether co-administration of triacontanol alters exposure docetaxel via inducing hepatic CYP3A1/2 activity. The concentration in rats pretreated with for seven successive days determined, and expression levels CYP3A protein mRNA were analyzed by western blot real time polymerase chain reaction (RT-PCR) technique, respectively.
This study aims to investigate auditory hypersensitivity and cortical function in migraine patients using the Hyperacusis Questionnaire Event-Related Potential (ERP) technique. The analyzes alterations latency amplitude of event-related potentials MMN P300 components. findings contribute a better understanding physiological relationship between hypersensitivity. Seventeen were admitted outpatient clinic Department Otorhinolaryngology-Head Neck Surgery at Peking University People's Hospital...