A5039350108- Cardiac Valve Diseases and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Advanced MRI Techniques and Applications
- Orthopaedic implants and arthroplasty
- Elasticity and Material Modeling
- Acute Ischemic Stroke Management
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Interference and Gene Delivery
- Hydraulic and Pneumatic Systems
- Nanoplatforms for cancer theranostics
- Trauma Management and Diagnosis
- Cardiovascular Issues in Pregnancy
Fifth Affiliated Hospital of Zhengzhou University
2025
Fudan University
2015-2024
Huashan Hospital
2015-2024
West China Medical Center of Sichuan University
2024
University of California, San Francisco
2013-2022
San Francisco VA Medical Center
2013-2022
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2022
Technical Institute of Physics and Chemistry
2019-2021
University of Chinese Academy of Sciences
2019-2021
Chinese Academy of Sciences
2019-2021
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role hemodynamics the progression aneurysmal disease be elucidated by patient-specific computational modeling. In our previous work, fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that thrombus-free and then proceeded to develop intraluminal thrombus. this study, we investigated effect...
Ventricular wall stress is believed to be responsible for many physical mechanisms taking place in the human heart, including ventricular remodeling, which frequently associated with heart failure. Therefore, normalization of cornerstone existing and new treatments In this paper, we sought construct reference maps normal humans that could used as a target silico optimization studies potential To do so, constructed personalized computational models left ventricles five subjects using magnetic...
Breast cancer develops from local tissue but is characterized by a distinct metastatic pattern involving regional lymph nodes and distant organs, which the primary cause of high mortality in breast patients. Herein, optimal docking nanoparticles (NPs) composed laurate-functionalized Pt(IV) prodrug (Pt(lau)), human serum albumin (HSA), lecithin were predicted computational modeling, prepared nanoprecipitation, validated fluorescence spectroscopy. As macrophages have been reported to be...
Aortic stenosis caused by valve calcification is a major cause of death around the world. Hemodynamic factors have been suggested to be players in development calcification, yet detailed knowledge blood flow dynamics as experienced endothelial cells on surfaces still lacking. In this study we carry out high-resolution numerical simulations through polymeric trileaflet order elucidate differential aortic and ventricular sides leaflets. Limiting streamlines surface shear stress contours are...
Transcatheter aortic valves (TAVs) are a promising treatment for high risk surgical patients suffering from degeneration of previously implanted bioprostheses (valve-in-valve therapy). However, unlike native stenosed which have accommodated Edwards SAPIEN transcatheter after valvuloplasty, rigid may prevent full TAV stent expansion and disrupt leaflet function. We hypothesized that current 23 mm TAVs would not completely relieve severe stenosis in small bioprosthetic valves. The objective...
Recently, a noninvasive method for determining regional myocardial contractility, using an animal-specific finite element (FE) model-based optimization, was developed to study sheep with anteroapical infarction (Sun et al., 2009, “A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in Sheep With Left Ventricular Aneurysm,” ASME J. Biomech. Eng., 131(11), p. 111001). Using the methodology previous 111001), which incorporates tagged magnetic resonance images,...
Alteplase is a widely used thrombolytic therapy for acute ischemic stroke (AIS). However, the efficacy of intravenous thrombolysis (IVT) with alteplase varies due to individual factors, and some patients are prone embolization recurrence (ER) after IVT. The mechanisms underlying these variations not fully understood. In this study, we analyzed changes in plasma lipid profiles AIS treated based on lipidomics, focusing association between lipids recurrence. Our findings revealed significant...
Studied under clinical trials, transcatheter aortic valves (TAV) have demonstrated good short-term feasibility and results in high-risk surgical patients with severe stenosis. However, their long-term safety durability are unknown. The objective of this study is to evaluate hemodynamic changes within TAV created by bioprosthetic leaflet degeneration.Computational fluid dynamics (CFD) simulations were performed the hemodynamics through sclerosis (35% orifice reduction) stenosis (78%...
Thromboembolic complications of bileaflet mechanical heart valves (BMHV) are believed to be due detrimental stresses imposed on blood elements by the hinge flows. Characterization these flows is thus crucial identify underlying causes for complications. In this study, we conduct three-dimensional pulsatile flow simulations through a BMHV under aortic conditions. Hinge and leaflet geometries reconstructed from Micro-Computed Tomography scans BMHV. Simulations conducted using Cartesian...