A5073011283- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Hydraulic and Pneumatic Systems
- Orthopaedic implants and arthroplasty
- Trauma Management and Diagnosis
- Cardiac Arrhythmias and Treatments
- Medical Imaging and Pathology Studies
- Tribology and Lubrication Engineering
- Cardiac pacing and defibrillation studies
- Elasticity and Material Modeling
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Iterative Learning Control Systems
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Antiplatelet Therapy and Cardiovascular Diseases
University of Denver
2015-2025
University of Utah
2016-2017
San Francisco VA Medical Center
2009-2013
Society of Thoracic Surgeons
2011-2013
University of California San Francisco Medical Center
2009-2012
University of California, San Francisco
2008-2012
University of Maryland, College Park
2011
University of California, Davis
2008
Background Limited data exist on clinical valve thrombosis after transcatheter aortic valve-in-valve (ViV) implantation. Our objective was to determine the incidence, timing, characteristics, and treatment outcomes of patients diagnosed with ViV thrombosis. Methods Results Centers participating in Valve-in-Valve International Data Registry were surveyed for cases, defined based a combination presence new dysfunction an imaging evidence leaflet Three hundred implantations included. The...
Leaflet thrombosis following transcatheter aortic valve replacement (TAVR) and valve-in-valve (ViV) procedures has been increasingly recognized. However, the factors affecting post-TAVR/ViV are not fully understood. This study aimed to investigate effect of geometric confinement (TAV) on blood residence time (BRT) TAV leaflets in turn post-TAVR thrombosis.Two computational models, representing a surgical bioprosthesis TAV, were developed BRT ViV setting/TAVR Intra-annular positioning. 3D...
Transcatheter aortic valves (TAVs) are a promising treatment for high risk surgical patients suffering from degeneration of previously implanted bioprostheses (valve-in-valve therapy). However, unlike native stenosed which have accommodated Edwards SAPIEN transcatheter after valvuloplasty, rigid may prevent full TAV stent expansion and disrupt leaflet function. We hypothesized that current 23 mm TAVs would not completely relieve severe stenosis in small bioprosthetic valves. The objective...
Transcatheter heart valve (THV) implantation in failed bioprosthetic valves (valve-in-valve [ViV]) offers an alternative therapy for high-risk patients. Elevated post-procedural gradients are a significant limitation of aortic ViV. Our objective was to assess the relationship between depth and haemodynamics.Commercially available THVs used ViV were included analysis (CoreValve Evolut, SAPIEN XT Portico valve). implanted small surgical (label size 19 mm) simulate boundary conditions....
Clinical and subclinical leaflet thromboses are increasingly recognized complications following transcatheter aortic valve replacement. Identification of the risk factors is important to mitigate occurrence thrombosis in valves (TAVs) ensure their long-term function. The goal this study was determine effect incomplete expansion TAVs on likelihood replacement.Using experimental computational methods, 3-dimensional unsteady flow fields 26-mm SAPIEN 3 expanded different diameters (i.e. 26.0 mm,...
Significant dilation of the pulmonary autograft is problematic after Ross operation and may require reoperation. Pulmonary remodelling occurs in response to immediate rise pressure consequently wall stress. Stress–strain root plays an important role understanding function following procedure. However, limited data are available on mechanical properties fresh human roots. The aim this study was compare aortic roots prior operation. Fresh healthy hearts (n = 21) were obtained from California...
Studied under clinical trials, transcatheter aortic valves (TAV) have demonstrated good short-term feasibility and results in high-risk surgical patients with severe stenosis. However, their long-term safety durability are unknown. The objective of this study is to evaluate hemodynamic changes within TAV created by bioprosthetic leaflet degeneration.Computational fluid dynamics (CFD) simulations were performed the hemodynamics through sclerosis (35% orifice reduction) stenosis (78%...
Transcatheter aortic valve (TAV) implantation has emerged as a revolutionary, minimally invasive treatment for inoperable or high-risk surgical patients with severe symptomatic stenosis. Since the first-in-man procedure in 2002, over 50,000 TAVs have been implanted worldwide. Fundamental differences application and design exist between TAV replacement. Computational experimental fluid dynamics are powerful techniques used engineering to fully understand implications of this new intervention....