A5049233519- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Infectious Aortic and Vascular Conditions
- Urologic and reproductive health conditions
- Tissue Engineering and Regenerative Medicine
- Urological Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Trauma Management and Diagnosis
- Elasticity and Material Modeling
- Bone and Joint Diseases
- Congenital heart defects research
- Pneumothorax, Barotrauma, Emphysema
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vitamin D Research Studies
- Traditional Chinese Medicine Studies
- Pericarditis and Cardiac Tamponade
- Advanced MRI Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Sexual Differentiation and Disorders
- Transplantation: Methods and Outcomes
First Hospital of Shanxi Medical University
2024-2025
Shanxi Medical University
2024-2025
University of California, San Francisco
2016-2024
San Francisco VA Medical Center
2016-2024
San Francisco VA Health Care System
2024
University of California San Francisco Medical Center
2016-2021
Candid
2020
Ruijin Hospital
2019
UCSF Benioff Children's Hospital
2016
Duke University Hospital
1986-1987
No AccessJournal of UrologyTumor/Trauma/Transplantation1 Apr 2016Canalization the Vestibular Plate in Absence Urethral Fusion Characterizes Development Human Clitoris: The Single Zipper Hypothesis Maya Overland, Yi Li, Mei Cao, Joel Shen, Xuan Yue, Sisir Botta, Adriane Sinclair, Gerald Cunha, and Laurence Baskin OverlandMaya Overland More articles by this author , LiYi Li CaoMei Cao ShenJoel Shen YueXuan Yue BottaSisir Botta SinclairAdriane Sinclair CunhaGerald Cunha BaskinLaurence View All...
Aortic dissection (AD) is a life-threatening event that occurs when the intimal entry tear propagates and separates inner from outer layers of aorta. Diameter, current criterion for aneurysm repair, far ideal additional evidence to optimize clinical decision would be extremely beneficial. Biomechanical investigation regional failure properties aortic tissue essential understand proactively prevent AD. We previously studied biaxial mechanical healthy human In this study, we investigated...
Ascending thoracic aortic aneurysms carry a risk of acute type A dissection. Elective repair guidelines are designed around size thresholds, but the 1-dimensional parameter maximum diameter cannot predict events in small aneurysms. Biomechanically, dissection can occur when wall stress exceeds strength. Patient-specific ascending aneurysm stresses may be better predictor Our aim was to compare tricuspid valve-associated based on diameter.Patients with and 4.0 cm or greater (n = 221) were...
Guidelines for sinus of Valsalva (SOV)-thoracic aortic aneurysms in Marfan syndrome recommend size-based criteria elective surgical repair. Biomechanics may provide a better prediction dissection risk than diameter. Our aim was to determine magnitudes wall stress the root patients using finite element analyses.Forty-six underwent patient-specific 3-dimensional SOV-thoracic aneurysm geometry reconstruction imaging data. Finite analyses were performed distributions at SOV, sinotubular junction...
Adverse remodeling of the left ventricle (LV) after myocardial infarction (MI) results in abnormal tissue biomechanics and impaired cardiac function, often leading to heart failure. We hypothesized that intramyocardial delivery engineered stromal cell-derived factor 1α analog (ESA), our previously-developed supra-efficient pro-angiogenic chemokine, preserves biaxial LV mechanical properties MI. Male Wistar rats (n = 45) underwent sham surgery 15) or permanent anterior descending coronary...
Historic studies of nonsyndromic ascending thoracic aortic aneurysms (aTAAs) reported that the typical aTAA growth rate was approximately 0.6 mm/year, but data were limited due to relatively few using computed tomography (CT) imaging. Our purpose reevaluate annual aTAAs do not meet criteria for surgical repair in veterans contemporary era, modern CT imaging suitable highly accurate and reproducible aneurysm measurement.Nonsurgical patients (diameter <5.5 cm) undergoing surveillance at a...
Rapid diameter growth is a criterion for ascending thoracic aortic aneurysm repair; however, there are sparse data on elongation rate. The purpose of this study was to assess rates in nonsyndromic, nonsurgical aneurysms understand length dynamics and correlate with over time.Patients <5.5-cm computed tomography angiography imaging at baseline 3-5 years follow-up underwent patient-specific three-dimensional reconstruction using MeVisLab. Aortic measured along the vessel centreline between...
Abstract OBJECTIVES Transcatheter aortic valve replacement (TAVR) is established therapy for severe stenosis patients with intermediate-, high- and prohibitive-risk surgery. A significant challenge when expanding TAVR to low-risk younger the unknown long-term durability. High leaflet stresses have been associated surgical bioprosthetic degeneration. In this study, we examined impact of changes in design across 3 generations same-sized devices on stent stresses. METHODS The 26-mm Edwards...
In ascending thoracic aortic aneurysm risk stratification, area/height ratio is a reasonable alternative to maximum diameter. Biomechanically, dissection may be initiated by wall stress exceeding strength. Our objective was evaluate the association between and peak stresses in relation valve morphology 3-year all-cause mortality.
Diameter-based risk stratification for elective repair of ascending aortic aneurysm fails to prevent type A dissection in many patients. Aneurysm wall stresses may contribute prediction; however, rates stress change over time are poorly understood. Our objective was examine changes 3-5 years and subsequent all-cause mortality.
The Ross procedure is an excellent option for children or young adults who need aortic valve replacement because it can restore survival to that of the normal aged-matched population. However, autograft remodeling lead aneurysmal formation and reoperation, biomechanics this process unknown. This study investigated postoperative after by examining patient-specific wall stresses.Patients have undergone had intraoperative pulmonary root specimens collected were recruited. Patient-specific...
Aims: As indications for transcatheter aortic valve replacement (TAVR) continue to expand towards younger and lower-risk patients, durability becomes an increasingly important question.Durability decreases as leaflet stresses increase, but the impact of heart (THV) size on stress is unknown.Patient annulus sizes can fall within "grey zones" between 2 TAVR sizes.Our aim was examine balloon-expandable THV stresses.Methods results: SAPIEN XT 23 mm, 26 29 mm valves underwent micro-computed...
Risk of aortic dissection in ascending thoracic aneurysms is not sufficiently captured by size-based metrics. From a biomechanical perspective, may be initiated when wall stress exceeds strength. Our objective was to assess the association between aneurysm peak stresses and 3-year all-cause mortality. Finite element analysis performed 273 veterans with chest computed tomography for surveillance aneurysms. Three-dimensional geometries were reconstructed models developed accounting prestress...
Acute type A aortic dissection (AD) is a catastrophic event associated with high mortality. Biomechanics can provide an understanding of the forces that lead initial intimal tear to propagate, resulting in dissection. We previously studied material properties normal human roots. In this study, our objective was determine regional and directional delamination healthy ascending aorta (AscAo) sinotubular junction (STJ).From 19 donor hearts, total 107 samples from AscAo STJ were collected tested...