A5046080544- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Helicobacter pylori-related gastroenterology studies
- Venous Thromboembolism Diagnosis and Management
- Mental Health Treatment and Access
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Regulation of Appetite and Obesity
- Child and Adolescent Psychosocial and Emotional Development
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- BRCA gene mutations in cancer
- Esophageal and GI Pathology
- Metabolomics and Mass Spectrometry Studies
Niigata University
2013-2025
Ningbo University
2023
Niigata University Medical and Dental Hospital
2011-2021
Mount Sinai Health System
2021
New York Eye and Ear Infirmary
2020
Icahn School of Medicine at Mount Sinai
2020
Mount Sinai Hospital
2019
Creative Commons
2019
Abstract Gut microbiota of breast-fed infants are generally rich in bifidobacteria. Recent studies show that infant gut-associated bifidobacteria can assimilate human milk oligosaccharides (HMOs) specifically among the gut microbes. Nonetheless, little is known about how bifidobacterial-rich communities shaped gut. Interestingly, HMOs assimilation ability not related to dominance each species. Bifidobacterium longum susbp. and breve commonly found as dominant species stools; however, they...
Both surgery and exogenous estrogen use are associated with increased risk of venous thromboembolism (VTE). However, it is not known whether hormone therapy (HT) exacerbates the surgery-associated among transgender gender nonbinary (TGNB) individuals. The lack published data has contributed to heterogeneity in perioperative protocols regarding HT administration for TGNB patients undergoing gender-affirming surgery.A single-center retrospective chart review was performed on all who underwent...
Intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC patients, an actionable gene alteration-based molecular classification that directly associates GCs with is needed.A total of 207 Japanese patients were included this study. Formalin-fixed, paraffin-embedded (FFPE) tumor tissues obtained from surgical or biopsy specimens and subjected DNA extraction. We generated comprehensive...
Comprehensive genomic sequencing (CGS) has the potential to revolutionize precision medicine for cancer patients across globe. However, date large-scale of been limited Western populations. In order understand possible ethnic and geographic differences explore broader application CGS other populations, we sequenced a panel 415 important genes characterize clinically actionable driver events in 201 Japanese with colorectal (CRC).Using next-generation methods, examined all exons known CRC (n =...
Abstract Purpose The aim of this study was to examine the clinical utility tumor-infiltrating lymphocytes (TILs) evaluated by “average” and “hot-spot” methods in breast cancer patients. Methods We examined 367 patients without neoadjuvant chemotherapy (NAC) average hot-spot determine consistency TIL scores between biopsy surgical specimens. before NAC were also compared with pathological complete response (pCR) rate outcomes 144 that received NAC. two predicted from clinicopathological data...
N6‐methyladenosine (m6A) is the most abundant RNA modification in mRNA and regulates various biological processes. The RNA‐binding properties of m6A writer proteins play an important role determining sites. METTL3 METTL14 form core complex, with as catalytic methyltransferase scaffold. Thus far, comprehensive binding METTL3/14 remain unknown. Using RNA‐capturing microsphere particles (R‐CAMPs), immobilizing fragments derived from endogenous RNAs human lung carcinoma cells, we isolated that...
Aims SMAD 4 acts as a tumour suppressor, and the loss of is associated with poor prognosis in colorectal cancer ( CRC ) patients. Although next‐generation sequencing NGS enabled us to detect numerous genetic alterations single assay, clinical significance alteration detected has not been fully investigated. The aim this study was evaluate clinicopathological characteristics . Methods results We retrospectively investigated 201 patients stage I– IV , by using 415‐gene panel. To analyse...
Right-sided colorectal cancer (RCRC) demonstrates worse survival outcome compared with left-sided CRC (LCRC). Recently, the importance of RNF43 mutation and BRAF V600E has been reported in serrated neoplasia pathway, which is one precancerous lesions RCRC. It was hypothesized that clinical significance differs according to primary tumor sidedness. To test this hypothesis, clinicopathological characteristics patients RCRC LCRC were investigated. Stage I-IV (n=201) analyzed. Genetic...
Abstract Background and Aims Decompensated cirrhosis with fibrosis progression causes portal hypertension followed by an oedematous intestinal tract. These conditions weaken the barrier function against bacteria in tract, a condition called leaky gut, resulting invasion bacterial components. Here, we investigated role of outer‐membrane vesicles (OMVs) Escherichia coli , which is representative pathogenic gut‐derived patients pathogenesis cirrhosis. Methods We involvement OMVs humans using...
Some bacteria are symbiotic in tumor tissues, and metabolites of several bacterial species have been found to cause DNA damage. However, date, the association between host genetic alterations colorectal cancer (CRC) has not fully investigated. We evaluated intra-tumor microbiome 29 Japanese CRC patients. The non-tumor tissues were extracted from patients, 16S rRNA genes sequenced for each sample. identified enriched tissues. bacteria, such as Fusobacterium, which is already known be CRC,...
Juvenile brain has a unique time window, or critical period, in which neuronal circuits are remodeled by experience. Mounting evidence indicates the importance of circuit rewiring various neurodevelopmental disorders human cognition. We previously showed that Otx2 homeoprotein, essential for formation, is recaptured during postnatal maturation parvalbumin-positive interneurons (PV cells) to activate period mouse visual cortex. Cortical only interneuron-enriched transcription factor known...
// Yoshifumi Shimada 1 , Hitoshi Kameyama Masayuki Nagahashi Hiroshi Ichikawa Yusuke Muneoka Ryoma Yagi 1, 2 Yosuke Tajima Takuma Okamura Masato Nakano Jun Sakata Takashi Kobayashi Nogami Satoshi Maruyama Yasumasa Takii Tetsu Hayashida 3 Hiromasa Takaishi 4 Yuko Kitagawa Eiji Oki 5 Tsuyoshi Konishi 6 Fumio Ishida 7 Shin-ei Kudo Jennifer E. Ring 8 Alexei Protopopov Stephen Lyle 8, 9 Yiwei Ling 10 Shujiro Okuda Ishikawa 11 Kohei Akazawa Kazuaki Takabe 12, 13 and Toshifumi Wakai Division of...
Despite the advances in surgical techniques and treatments, prognosis of esophageal cancer remains poor, since disease is usually diagnosed at an advanced stage. Therefore, prevention plays important role reducing mortality. Smoking alcohol intake are modifiable habits risk factors for cancer. However, number large-scale studies that have investigated association amount duration smoking with risk, while accounting effects gender subtypes (squamous cell carcinoma adenocarcinoma), limited....
Next-generation sequencing (NGS) has enabled comprehensive detection of genomic alterations in lung cancer. Ethnic differences may play a critical role the efficacy targeted therapies. The aim this study was to identify and compare adenocarcinoma between Japanese patients Cancer Genome Atlas (TCGA), which majority are from US. We also aimed examine prognostic impact additional harboring EGFR mutations. Genomic were determined with (N = 100) using NGS-based 415 known cancer genes, correlated...
The stigma of schizophrenia constitutes a major barrier to early detection and treatment this illness. Anti-stigma education has been welcomed reduce among the general public. This study examined factors associated with effectiveness web-based educational program designed schizophrenia. Using Link's Devaluation-Discrimination Scale measure stigma, effect was measured by difference in pre- post-program tests. In present study, we focused on participants whose towards had considerably improved...
Polyamines are aliphatic hydrocarbons with terminal amino groups and essential for biological activities. It has been reported that polyamines have health-promoting effects in animals, such as the extension of lifespan by polyamine intake. The identification a high polyamine-producing bacterium from foods could lead to development novel probiotic candidate. We aimed identify bacteria food, isolated collected vegetables fermented produced Japan. successfully acquired Latilactobacillus...
The incidence of esophageal squamous cell carcinoma (ESCC), which is the eighth most common malignancy worldwide, highest in China. purpose this study was to investigate association between nitrogen compounds drinking water with ESCC by geographical spatial analysis. high Shexian county, China, and environmental factors, particularly nitrogen-contaminated water, are main suspected risk factors. This focuses on three namely, nitrates, nitrites, ammonia, all derived mainly from domestic...
Comprehensive genomic sequencing (CGS) enables us to detect numerous genetic alterations in a single assay. We aimed identify molecular markers for predicting prognosis and conversion surgery Stage IV colorectal cancer (CRC) using CGS. One-hundred eleven patients with CRC who underwent primary tumor resection were analyzed. retrospectively investigated CGS of 415-gene panel. Clinicopathological variables analyzed independent prognostic factors overall survival (OS). Forty-five 111 had R0...
Gastric cancer is one of the most common and clinically important diseases worldwide. The traditional Laeuren classification divides gastric into two histopathological subtypes: diffuse intestinal. Recent genomics research has led to development a new based on molecular characteristics. newly defined genomically stable (GS) subtype shares many cases with histopathologically type. In this study, we performed genetic profiling recurrently significantly mutated genes in type GS tumors. We...
Although numerous experiments revealed an essential role of a lipid mediator, sphingosine-1-phosphate (S1P), in breast cancer (BC) progression, the clinical significance S1P remains unclear due to difficulty measuring lipids patients. The aim this study was determine plasma concentration estrogen receptor (ER)-positive BC patients, as well investigate its significance. We further explored possibility treatment strategy targeting ER-positive patients by examining effect FTY720, functional...
Highlights•CSGalNAcT1-KO did not suffer from diabetic neuropathy following induced hyperglycemia•Retinal pericytes in CSGalNAcT1-KO were resistant to anti-PDGFβR•WT involved TGF-β signaling, whereas notSummaryDiabetic (DN) is a major complication of diabetes mellitus. Chondroitin sulfate (CS) one the most important extracellular matrix components and known interact with various diffusible factors; however, its role DN pathology has been examined. Therefore, we generated CSGalNAc-T1 knockout...