A5036289394- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Sphingolipid Metabolism and Signaling
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2016-2025
The Japanese Society of Gastroenterological Surgery
2023
Cambridge University Hospitals NHS Foundation Trust
2023
University at Buffalo, State University of New York
2018-2019
Roswell Park Comprehensive Cancer Center
2018-2019
Obayashi (Japan)
2018
University of Massachusetts Chan Medical School
2018
Virginia Commonwealth University
2014-2018
Niigata Cancer Center Hospital
2017-2018
Abstract p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that degraded by autophagy. Amplification of the gene, aberrant accumulation phosphorylation p62/Sqstm1, have been implicated tumour development. Herein, we reveal molecular mechanism p62/Sqstm1-dependent malignant progression, suggest targeting represents potential chemotherapeutic approach against hepatocellular carcinoma (HCC). Phosphorylation at Ser349 directs glucose to glucuronate pathway,...
Although obesity with associated inflammation is now recognized as a risk factor for breast cancer and distant metastases, the functional basis these connections remain poorly understood. Here, we show that in patients animal models, sufficient cause increased expression of bioactive sphingolipid mediator sphingosine-1-phosphate (S1P), which mediates pathogenesis. A high-fat diet was to upregulate sphingosine kinase 1 (SphK1), enzyme produces S1P, along its receptor S1PR1 syngeneic...
The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for management biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published 2nd version 2014.In this 3rd version, questions (CQs) were proposed on six topics. recommendation, grade statement each CQ discussed finalized by an evidence-based approach. Recommendations graded as Grade 1 (strong) or 2 (weak) according to concepts Grading Assessment,...
Abstract BACKGROUND The current study was performed to clarify whether the presence of residual carcinoma in situ at ductal resection margins differs prognostically from invasive lesions patients undergoing surgical for extrahepatic cholangiocarcinoma. METHODS A retrospective analysis 84 with cholangiocarcinoma who underwent conducted. margin status classified as negative ( n = 64 patients), positive 11 or 9 patients). median follow‐up period 105 months. RESULTS Ductal found be a strong...
Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death. Although important roles of sphingolipids breast progression been reported experimental models, their human patients are yet to be revealed. The aim this study was investigate the ceramide levels its biosynthesis pathways patients. Breast cancer, peri-tumor normal tissue samples were collected from surgical specimens a series 44 with cancer. amount sphingolipid metabolites determined by mass...
This study was designed to address whether gallbladder cancer invading the muscle layer (stage pT(1b)) is a local disease and radical resection necessary.A retrospective analysis of 25 patients with pT(1b) tumours, 13 whom underwent simple cholecystectomy 12 regional lymph node dissection, performed. A total 147 nodes examined for metastasis. The median follow-up time 95 months.No patient had blood vessel or perineural invasion on histology. Lymphatic seen in one patient. Both overt...
Although inorganic arsenate (iAsV) or arsenite (iAsIII) is clearly a human carcinogen, it has been difficult to produce tumors in rodents. In the present study, we orally administered iAsV A/J mice examine arsenic carcinogenicity rodent. (male, n = 120) assigned four groups were given drinking water containing 0, 1, 10, and 100 ppm for 18 months. At end of experiment, complete lungs removed used examining histopathology extracting RNA DNA. Epigenetic effects on DNA methylation patterns...
<b><i>Background:</i></b> Despite the increasing number of reports on favorable outcomes laparoscopic surgery for gallbladder cancer (GBC), there is no consensus regarding this surgical procedure. <b><i>Objective:</i></b> The study aimed to develop a statement application GBC based expert opinions. <b><i>Methods:</i></b> A meeting among experts was held September 10, 2016, in Seoul, Korea....
Assessment of lymph node status is a critical issue in the surgical management gallbladder cancer. The aim this study was to compare anatomical location positive nodes, number and ratio (LNR) as prognostic predictors We conducted retrospective analysis 135 patients with cancer who underwent radical resection regional lymphadenectomy. A total 2,245 nodes were retrieved (median, 14 per patient). classified according AJCC staging manual (7th edition). 'Optimal' cutoff values determined for LNR...