A5070389757- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Retinoids in leukemia and cellular processes
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- Energy and Environment Impacts
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Inhalation and Respiratory Drug Delivery
- Occupational and environmental lung diseases
- Ubiquitin and proteasome pathways
- Occupational exposure and asthma
- Vehicle emissions and performance
- Effects and risks of endocrine disrupting chemicals
- Graphene and Nanomaterials Applications
- Toxic Organic Pollutants Impact
- Carbohydrate Chemistry and Synthesis
- Sulfur Compounds in Biology
- Fluoride Effects and Removal
- Estrogen and related hormone effects
- Atmospheric chemistry and aerosols
- RNA Interference and Gene Delivery
National Institute for Environmental Studies
2016-2025
Chiba University
1996-2016
Kamakura Women's University
2012
Tohoku University
2012
Jikei University School of Medicine
2006
Instituto Português Da Qualidade
2005
European Science Foundation
2005
Tottori University
1978-2004
Tsurumi University
2004
Norwegian Cancer Society
2004
Although inorganic arsenate (iAsV) or arsenite (iAsIII) is clearly a human carcinogen, it has been difficult to produce tumors in rodents. In the present study, we orally administered iAsV A/J mice examine arsenic carcinogenicity rodent. (male, n = 120) assigned four groups were given drinking water containing 0, 1, 10, and 100 ppm for 18 months. At end of experiment, complete lungs removed used examining histopathology extracting RNA DNA. Epigenetic effects on DNA methylation patterns...
BackgroundAlthough adverse health effects of particulate matter with a diameter < 100 nm (nanoparticles) have been proposed, molecular and/or experimental evidence for their facilitation lung inflammation in vivo is not fully defined.ObjectiveIn the present study we investigated nanoparticles on related to bacterial endotoxin [lipopolysaccharide (LPS)] mice.ResultsWe intratracheally administered vehicle, two sizes (14 nm, 56 nm) carbon black (4 mg/kg), LPS (2.5 or plus and evaluated...
The tissue distribution and chemical forms of arsenic were compared in two animal species with different metabolic capacity toxicity to arsenic. Hamsters rats given a single oral dose arsenite (iAsIII) at 5.0 mg As/kg body weight, then the concentrations determined; more than 75% accumulated rat red blood cells (RBCs) form dimethylarsinous acid (DMAIII), whereas less 0.8% hamster RBCs, mostly monomethylarsonous (MMAIII). Reflecting low accumulation 63% was recovered urine within one week...
Recent toxicological studies indicate that nanoparticles or ultrafine particles (< 100 nm) are more toxic than fine 2 microm) because of their greater surface area. It is well known alveolar macrophages play an important role in the first defense against various environmental and microorganisms. This accomplished by binding to a macrophage receptor with collagenous structure (MARCO), one several scavenger-type receptors expressed on cell macrophages. MARCO has been shown mediate ingestion...
Abstract Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the commercially used types of (chrysotile, crocidolite, and amosite), carcinogenicity chrysotile not fully appreciated. Here, we show that all three similarly induced MM rat peritoneal cavity caused earliest development with high fraction sarcomatoid histology. The pathogenesis chrysotile‐induced mesothelial carcinogenesis was closely associated iron overload: repeated administration an chelator,...
Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown. We investigated effects of PAMAM with various surface functional groups multiple generations on neuronal differentiation using human neural progenitor cells at an equal mass concentration. Only containing amine (NH2) concentrations 10 μg/mL significantly reduced cell viability differentiation,...
For the past three decades, most attention in heavy metal toxicology has been paid to cadmium, mercury, lead, chromium, nickel, vanadium, and tin because these metals widely polluted environment.However, with development of new materials last decade, need for toxicological studies on those increasing.A group rare earths (RE) is a good example.Although some RE have used superconductors, plastic magnets, ceramics, few data are available compared other described above.Because chemical...