A5047256984- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Cancer Treatment and Pharmacology
- Neurogenesis and neuroplasticity mechanisms
- Virus-based gene therapy research
- Cancer therapeutics and mechanisms
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Moyamoya disease diagnosis and treatment
- Radiopharmaceutical Chemistry and Applications
- Neurological Disorders and Treatments
Hokkaido University
2009-2024
Asahi Kasei (Japan)
2014-2022
Hokkaido Pharmaceutical University
2006-2018
Tsurumi University
2009-2017
Osaka University
1992-2015
Obihiro University of Agriculture and Veterinary Medicine
2014-2015
Chuo University
2009-2011
Tokyo Women's Medical University
2010
Railway Technical Research Institute
2010
National Disaster Medical Center
2009
✓ A computer-assisted neurosurgical navigational system has been developed which displays intraoperative manipulation on the preoperative computerized tomography (CT) scans or magnetic resonance (MR) images. The consists of a three-dimensional digitizer, personal computer, and an image-processing unit. Utilizing recently field modulation technology, digitizer determines spatial position orientation angles resin probe, triangle-shaped pointer, suction tube with small attached sensor. Four...
Here we report the cloning and functional characterization of a rat novel peptide/histidine transporter (PHT1), which was expressed in brain retina. The cDNA encodes predicted protein 572 amino acid residues with 12 putative membrane-spanning domains. sequence has moderate homology nonspecific peptide found plant. When Xenopus laevis oocytes, PHT1 cRNA induced high affinity proton-dependent histidine transport activity. This process inhibited by dipeptides tripeptides but not free acids such...
In the focal infarction model of rat middle cerebral artery (MCA), thalamus occluded side becomes gradually atrophic, mainly because retrograde degeneration. We determined whether basic fibroblast growth factor (bFGF) administered intracisternally could prevent this thalamic atrophy. left MCA through a small cranial opening, and animals were then divided into two groups. One group received intra-cisternal injections recombinant bFGF (1 μg dissolved in 0.1 ml saline with 2% serum) starting 1...
In this study, collagen extracted from chicken legs (which are the yellow keratin parts containing a nail) was hydrolyzed with various enzymes, and angiotensin I-converting enzyme (ACE)-inhibitory activity of each hydrolysate determined. The by treatment an Aspergillus species-derived had highest (IC 50 = 260 microg/mL). fraction obtained ultrafiltration molecular-weight cutoff 3000 Da (low fraction) stronger 130 microg/mL) than fractionated one. This further HPLC, peptides in high...
Gliomas, characterized by their progressively invasive phenotype, express integrin alpha3beta1 as a major receptor for the extracellular matrix both in vivo and vitro. Since has been shown to be specific laminin-5 (alpha3beta3gamma2), we examined effects of purified human on adhesion, migration invasion glioma cells. Among different types laminin variants other proteins including fibronectin vitronectin, was most potent promoting adhesion kinds Laminin-5-mediated were specifically inhibited...
✓ An experimental model for blood-borne cerebral metastases was developed by introducing Walker 256 carcinoma cells selectively into the intracranial internal carotid artery of rats. This used to study regional capillary permeability rat brain and metastatic tumors various sizes with aid 14 C alpha-aminoisobutyric acid (AIB) quantitative autoradiography. The varied anatomical location size tumor. Intraparenchymal less than 1 mm in diameter showed no increased AIB. As enlarged over diameter,...
A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung carcinoma. One hundred were randomly divided into three groups at time diagnosis or after surgery for metastases. Group received radiotherapy alone; B and chloroethylnitrosoureas (methyl-CCNU, 100-120 mg/m2, ACNU 80-100 every 6-8 weeks), C a combination tegafur (300 daily). Of 100 patients, 88 could be evaluated. The reduction rates tumors whom tumor not...
We studied functional disturbances following left middle cerebral artery occlusion in rats. Neuronal function was evaluated by [14C]2-deoxyglucose autoradiography 1 day after occlusion. analyzed the mechanisms of change glucose utilization outside infarct using Fink-Heimer silver impregnation, axonal transport wheat germ agglutinin-conjugated-horseradish peroxidase, and succinate dehydrogenase histochemistry. One occlusion, remarkably reduced areas surrounding infarct. There were many grains...
A novel scaffold material based on an alginate hydrogel which contained carbon nanotubes (CNTs) was prepared, and its mechanical property biocompatibility evaluated. Soluble CNTs were prepared with acid treatment dispersed in sodium solution as a cross-linker. After which, the (elastic deformation), saline sorption, histological reaction, cell viability of resultant nanocomposite gel (CNT-Alg gel) The CNT-Alg showed faster gelling higher strength than conventional gel. Saline sorption amount...
✓ An experimental model of spinal epidural neoplasm was produced in rats by injecting Walker 256 carcinoma cell suspension anterior to the T12–13 vertebral body. With this model, cord blood flow (SCBF) and its response CO 2 inhalation were estimated carbon-14-antipyrine autoradiography hydrogen clearance methods. In early stages after tumor implantation, weakness, axonal swelling, edema white matter observed, while both SCBF remained normal. next stage, invaded canal compressed epidurally....
Regional cerebral blood flow (CBF) was measured in both middle ectosylvian gyri of ten cats by recording the clearance molecular hydrogen (H 2 ) with implanted polarized electrodes 125 µ diameter, before and up to seven days after occlusion left artery (MCA) a device intact cranium. Five patterns changes CBF were recorded leftsided electrodes. In eight MCA caused immediate decreases CBF; other two values lowest occlusion, presumably because ischemic edema. Both persistent severe ischemia...
✓ Quantitative autoradiographic technique was applied in measuring blood-brain barrier (BBB) permeability of autochthonous gliomas rats. In small tumors (less than 2 mm diameter), no increase BBB noted. As the tumor grew and neovascularization occurred, increased center tumor, it suggested that partly disrupted neovascularized vessels. fully grown tumors, markedly viable part to levels similar choroid plexus. Yet, preserved at periphery brain adjacent tumor. The heterogeneity phenomenon...
✓ Peritumoral brain edema was produced by intracerebral transplantation of Walker 256 tumor in rats. Local cerebral blood flow (LCBF), local glucose utilization (LCGU), and capillary permeability were studied untreated methylprednisolone-treated rats quantitative autoradiography. In the group, LCBF LCGU widely depressed cortex deep structures hemisphere ipsilateral to tumor. animals, significantly better than animals. Capillary highly increased viable part lower that group. These results may...
Abstract The overall distribution of substance P‐like immunoreactivity (SPI) in the wall cerebral arteries and their origins were investigated guinea pig by using whole‐mounts. Two types SPI fibers seen: one forming dense fiber bands lo‐cated among periadventitial nerves, other a meshwork. located nerves often leave these to form meshwork varying density according diame‐ter or location blood vessels. present study suggests that: (1) on circle Willis its branches originate from cells...
The authors describe the techniques employed in three patients with basilar artery aneurysms that were treated via transoral transclival approach. To prevent formation of cerebrospinal fluid fistulas and risk consequent meningitis, complete postoperative closure nasopharyngeal mucosa is essential. Long-term packing continuous spinal drainage found to be effective these cases.
Acute occlusion of the left middle cerebral artery (MCA) was accomplished without anesthesia and inside an intact cranium containing cerebrospinal fluid (CSF) in ten cats five to nine days after implantation occlusive device through orbit. Immediate neurological deficits included forced ambulation, circling, tonic deviation head neck toward side occluded artery; weakness opposite limbs; apathetic or akinetic state. Two died within 24 hours. The other eight improved, but secondary developed...