A5025994244- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Atomic and Subatomic Physics Research
- bioluminescence and chemiluminescence research
- Radiopharmaceutical Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Cardiovascular Function and Risk Factors
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Advanced Text Analysis Techniques
- Radiomics and Machine Learning in Medical Imaging
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Biosensing Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Web Data Mining and Analysis
- Virus-based gene therapy research
Kitasato University
2015-2024
Gunma University
2008-2024
Tokushima University Hospital
2024
Hiroshima City Asa Citizens Hospital
2023-2024
Hamamatsu University School of Medicine
2020-2024
Kitasato University Hospital
2016-2024
Citizens Specialty Hospitals
2023
Akita University
2023
Japanese Foundation For Cancer Research
2006-2022
Kyushu University
2007-2020
Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC encodes hepcidin, first mammalian liver-specific antimicrobial peptide and potential key regulator of metabolism. Here we demonstrate that during rat liver development, amounts transcripts were very low fetal strongly transiently increased shortly after birth, reappeared adult liver. To gain insight into mechanisms regulate hepatic expression 5′-flanking regions human genes isolated analyzed functional DNA...
Diffusion-weighted imaging provides a novel contrast mechanism in magnetic resonance (MR) and has high sensitivity the detection of changes local biologic environment. A significant advantage diffusion-weighted MR over conventional material-enhanced is its to change microscopic cellular environment without need for intravenous material injection. Approaches assessment breast findings include these data alone interpretation conjunction with T2-weighted findings. In addition, analysis apparent...
Anti-1-amino-3-<sup>18</sup>F-fluorocyclobutane-1-carboxylic acid (<sup>18</sup>F-FACBC) is a synthetic amino analog PET radiotracer undergoing clinical trials for the evaluation of prostate and other cancers. We aimed to describe common physiologic uptake patterns, incidental findings, variants in patients who had undergone <sup>18</sup>F-FACBC PET. <b>Methods:</b> Sixteen involving 611 studies from 6 centers, which included dosimetry on 12 healthy volunteers, were reviewed. Qualitative...
ABSTRACT To establish a safer and more effective vaccine against pneumococcal respiratory infections, current knowledge regarding the antigens common among strains improvements to system for delivering these across mucosal barrier must be integrated. We developed that combines advantages of surface protein A (PspA) with nontoxic intranasal delivery based on nanometer-sized hydrogel (nanogel) consisting cationic cholesteryl group-bearing pullulan (cCHP). The efficacy nanogel-based PspA nasal...
Non-alcoholic fatty liver disease is frequently associated with type 2 diabetes, and constitutes an important risk factor for the development of hepatic fibrosis hepatocellular carcinoma. Because there remains no effective drug therapy non-alcoholic we evaluated efficacy sodium-glucose cotransporter inhibitor.In present pilot, prospective, non-randomized, open-label, single-arm study, effect 100 mg canagliflozin administered once daily 12 months on serological markers, body composition...
The fetal liver, the major site of hematopoiesis during embryonic development, acquires additional functions near birth. Among important liver is response to xenobiotic exposure due expression several cytochromes P450 (CYP) and drug efflux transporters. Expression these genes regulated by nuclear receptors such as pregnane X receptor (PXR). In this study, regulation responses development was analyzed using a hepatocyte primary culture system derived from day 15 (E15) livers. Hepatocyte...
We investigated the effect of diet on abdominal autofluorescence detected by in vivo fluorescence imaging (FLI) living mice. Groups mice were fed a regular, alfalfa-free, or purified diet, and whole-body FLI was performed without administration fluorescent probes. In addition, quantum dots injected intravenously into one three diets, 3 24 hours later. Intense originating from animals' intestinal contents observed regular diet. Intestinal decreased substantially after feeding with...
The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to portion of anterior cingulate (ACC) is implicated anxiogenesis hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred connectivity (FC) affects anxiety cortisol concentrations everyday life. Here, we investigate relationship between daily (dCOR) FC during emotional processing forty-one healthy humans....
The immune system has major roles in the brain and related psychopathology. Disrupted interleukin-6 secretion aberrant amygdala emotional reactivity are well-documented stress-related mental disorders. regulates psychosocial affected by genes. These led us to comprehensively examine relationship between interleukin-6, activity, symptoms under gene-stressor interactions.One hundred eight nonclinical participants with various levels of anxiety/depression underwent magnetic resonance imaging...
Many lines of evidence indicate that neoplastic transformation cells occurs by a multistep process. For normal human cells, they must be first immortalized and then converted into cells. It is well known the immortalization critical step for immortal phenotype recessive. Thus, we investigated proteins downregulated in two-dimensional gel electrophoresis. As result, S100C, Ca(2+)-binding protein, was dramatically fibroblasts compared with their counterparts. When reached confluence, S100C...
A novel scaffold material based on an alginate hydrogel which contained carbon nanotubes (CNTs) was prepared, and its mechanical property biocompatibility evaluated. Soluble CNTs were prepared with acid treatment dispersed in sodium solution as a cross-linker. After which, the (elastic deformation), saline sorption, histological reaction, cell viability of resultant nanocomposite gel (CNT-Alg gel) The CNT-Alg showed faster gelling higher strength than conventional gel. Saline sorption amount...
ObjectiveWe performed a multicenter Phase IIb clinical trial of NMK36, novel amino acid analog for positron emission tomography containing trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid, to evaluate its safety and diagnostic performance primary prostate cancer.
Anxiety and depression are linked to both explicit implicit memory biases, which defined as the tendency preferentially recall emotionally negative information at conscious subconscious levels, respectively. Functional connectivity (FC) of basolateral amygdala (BLA) related stress hormones (i.e., cortisol norepinephrine) purportedly implicated in these biases. However, previous findings on biases anxiety have been inconsistent, likely due their symptomatic complications. Therefore,...
To assess the effect of motion artifact reduction on diffusion-weighted magnetic resonance imaging (DWI-MRI) liver, we compared velocity-compensated DWI (VC-DWI) and VC-DWI combined with tetrahedral gradients (t-VC-DWI) to conventional (c-DWI) in assessment apparent diffusion coefficients (ADCs) liver.In 12 healthy volunteers, liver was scanned c-DWI, VC-DWI, t-VC-DWI sequences. The signal-to-noise ratio (SNR) ADC parenchyma were measured among sequences.The image quality visually better for...
Endomyocardial biopsy (EMB) and late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) imaging performed at baseline are both used to evaluate the extent of myocardial fibrosis. However, no study has directly compared effectiveness these diagnostic tools in prediction left ventricular reverse remodeling (LVRR) prognosis response therapy patients with idiopathic dilated cardiomyopathy (IDCM). Seventy-five newly diagnosed IDCM who were undergoing optimal assessed using LGE-CMR...