A5050926503- Plant-Microbe Interactions and Immunity
- Cardiovascular Function and Risk Factors
- Plant Pathogens and Fungal Diseases
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Advanced Glycation End Products research
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Plant Pathogenic Bacteria Studies
- Plant Disease Resistance and Genetics
- Mycotoxins in Agriculture and Food
- Fungal Biology and Applications
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Cardiac Arrest and Resuscitation
- Mycorrhizal Fungi and Plant Interactions
- Dialysis and Renal Disease Management
- Cardiac Arrhythmias and Treatments
- Trypanosoma species research and implications
- Viral Infections and Immunology Research
- Legume Nitrogen Fixing Symbiosis
- Sarcoidosis and Beryllium Toxicity Research
Setsunan University
2020-2025
Kitasato University
2015-2025
Tokyo University of Information Sciences
2025
National Agriculture and Food Research Organization
2015-2025
The University of Tokyo
2025
Okayama University Hospital
2025
Tokyo University of Science
2019-2020
Institute of Vegetable and Floriculture Science
2014-2019
Kinan Hospital
2019
Wageningen University & Research
2014-2015
beta 2-Microglobulin (beta 2M) is a major constituent of amyloid fibrils in hemodialysis-associated amyloidosis, complication long-term hemodialysis patients. Amyloid fibril proteins were isolated from connective tissues forming carpal tunnels patients with tunnel syndrome. Two-dimensional polyacrylamide gel electrophoresis and Western blotting demonstrated that most the 2M exhibited more acidic pI value than normal 2M. This was also found small fraction sera urine these patients, whereas...
beta 2-Microglobulin (beta 2M) is a major constituent of amyloid fibrils in hemodialysis-associated amyloidosis (HAA), complication long-term hemodialysis. However, the pathological role 2M HAA remains to be determined. Recently, we demonstrated that deposits modified with advanced glycation end products (AGEs) Maillard reaction. Since AGEs have been implicated tissue damage associated diabetic complications and aging, investigated possible involvement AGE-modified (AGE-beta pathogenesis...
An important component of amyloid fibrils in dialysis-related amyloidosis is a form beta2microglobulin modified with advanced glycation end products (AGEs) the Maillard reaction, known as AGE-beta2M. We demonstrate here that interaction AGE-beta2M mononuclear phagocytes (MPs), cells pathogenesis inflammatory arthropathy amyloidosis, mediated by receptor for AGEs, or RAGE. 125I-AGE-beta2M bound to immobilized RAGE MPs specific, dose-dependent manner (Kd approximately 53.5 and 81.6 nM,...
Pentosidine is an advanced glycation end product and its formation shown to be closely related oxidative processes. Recent studies have that pentosidine levels are increased not only in plasma matrix proteins from diabetic patients, but also markedly nondiabetic hemodialysis patients. Currently, the mechanism of accumulation kinetics patients remain unknown. Gel filtration uremic revealed exists albumin fraction (approximately 90%) and, interestingly, free form 5%) as well. Plasma was...
As part of their defense strategy against fungal pathogens, plants secrete chitinases that degrade chitin, the major structural component cell walls. Some fungi are not sensitive to plant because they chitin-binding effector proteins protect wall these enzymes. However, it is known how pathogens lack effectors overcome this barrier. Here, we investigated ability tomato cleave domain (CBD)-containing and its effect on virulence. Four CBD were produced in Pichia pastoris incubated with...
Abstract Aims Non‐dilated left ventricular cardiomyopathy (NDLVC) was proposed as a new category of that included patients with non‐left (LV) dilatation, LV wall motion abnormality, or scar. However, the clinical background and event rates NDLVC were unclear. The aim this study to examine characteristics reduced ejection fraction (NDLVC–REF) in comparison those dilated (DCM). Methods results We retrospectively 363 newly diagnosed non‐ischaemic (<50%) between December 2004 January 2018....
Cladosporium fulvum is a biotrophic fungal pathogen that causes leaf mould of tomato. Analysis its genome suggested high potential for production secondary metabolites (SM), which might be harmful to plants and animals. Here, we have analysed in detail the predicted SM gene clusters C. employing phylogenetic comparative genomic approaches. Expression core genes was measured by RT-qrtPCR produced SMs were determined LC-MS NMR analyses. The contains six are conserved other species, undergone...
Background and Objectives: Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors have been approved as an oral drug for treating anemia in chronic kidney disease (CKD). However, the clinical effect of HIF-PH patients with heart failure (HF) is unclear. Thus, this study investigated HF CKD. Materials Methods: Thirteen complicated by renal who were started on vadadustat enrolled. Clinical parameters compared before 1 month after was started. Results: The mean left ventricular...
The entomopathogenic fungus Beauveria bassiana is used commercially as a microbial insecticides against wide range of agricultural insect pests. Some strains B. protect the plants from pathogens, but underlying mechanisms are largely unknown. Here, we found that prophylactic sprays commercial bioinsecticide Botanigard on cucumber, tomato, and strawberry suppressed severity economically damaging powdery mildews. On leaf surfaces, hyphal elongation spore germination cucumber mildew,...
Summary Leaf mould, caused by Fulvia fulva , is a devastating disease of tomato plants. In many commercial cultivars, resistance to this governed the Cf‐9 locus, which encodes five paralogous receptor‐like proteins. Two these proteins confer resistance: Cf‐9C recognises previously identified F. effector Avr9 and provides during all plant growth stages, while Cf‐9B yet‐unidentified Avr9B mature only. recent years, strains have emerged that can overcome with circumvented through deletion. To...
ABSTRACT Purpose To assess adverse neurological risks following influenza vaccination in older adults. Methods Using a linked database of healthcare administrative claims data and records from an urban city Japan (April 1, 2014, to March 31, 2020), we conducted observational study utilizing self‐controlled case series design. We identified individuals aged ≥ 65 years who experienced outcomes, defined as hospitalizations related epilepsy, paralysis, facial neuralgia, neuritis, optic migraine,...
ABSTRACT Leaf mold caused by the ascomycete fungus Cladosporium fulvum is a devastating disease of tomato plants. The mycoparasitic Hansfordia pulvinata an effective biocontrol agent that parasitizes C. hyphae on leaves and secretes 13-deoxyphomenone, eremophilane-type sesquiterpene, which was also identified as sporulation-inducing factor in Aspergillus oryzae . Here, we deoxyphomenone biosynthesis ( DPH ) gene clusters conserved both H. section Flavi , including A. flavus Functional...
Summary The filamentous fungus Fusarium oxysporum is a soil‐borne parasite that causes vascular wilts in wide variety of crops by directly penetrating roots and colonizing the tissue. In previous work, we generated non‐pathogenic mutant B137 melon wilt pathogen F. f. sp. melonis using restriction enzyme‐mediated integration (REMI) mutagenesis. Molecular characterization revealed this has single‐copy plasmid insertion gene, designated FOW2 , which encodes putative transcription regulator...
Leaf mold of tomato is caused by the biotrophic fungus Cladosporium fulvum which complies with gene-for-gene system. The disease was first reported in Japan 1920s and has since been frequently observed. Initially only race 0 isolates were reported, but consecutive introduction resistance genes Cf-2, Cf-4, Cf-5 Cf-9 new races have evolved. Here we determined virulence spectrum 133 C. collected from 22 prefectures Japan, subsequently sequenced avirulence (Avr) Avr2, Avr4, Avr4E, Avr5 Avr9 to...
Beauveria bassiana, known for its entomopathogenic characteristics, is the most widely used biocontrol agent against many insect pests and may also be active soil-borne pathogens. It inhabits surfaces or inner tissues of various plant species without causing any visible signs symptoms. Here we show that B. bassiana strain GHA, ingredient a commercial microbial insecticide, colonises tomato plants. GHA grew on intact leaf in high humidity, but never entered stomata. Viable hyphae conidia were...
Endomyocardial biopsy (EMB) and late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) imaging performed at baseline are both used to evaluate the extent of myocardial fibrosis. However, no study has directly compared effectiveness these diagnostic tools in prediction left ventricular reverse remodeling (LVRR) prognosis response therapy patients with idiopathic dilated cardiomyopathy (IDCM). Seventy-five newly diagnosed IDCM who were undergoing optimal assessed using LGE-CMR...
Abstract The rhizosphere microbial community in a multiple parallel mineralization ( MPM ) system contributes to suppression of root‐borne diseases. We hypothesized this phenomenon can be attributed the interplay non‐antagonistic bacteria rather than single antagonistic microbe. In study, we tested hypothesis by investigating potential roles bacterial subset microbiota fungal phytopathogen Fusarium oxysporum . Bacterial strains isolated from were subjected vitro and planta tests on F. A...
The rhizosphere microbial community in a hydroponics system with multiple parallel mineralization (MPM) can potentially suppress root-borne diseases. This study focused on revealing the biological nature of suppression against Fusarium wilt disease, which is caused by fungus oxysporum, and describing factors that may influence fungal pathogen MPM system. We demonstrated microbiota developed could disease under vitro greenhouse conditions. microbiological characteristics were able to control...