A5083970384- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Sleep and related disorders
- Sleep and Wakefulness Research
- Action Observation and Synchronization
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Intergenerational Family Dynamics and Caregiving
- Eating Disorders and Behaviors
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Mental Health and Psychiatry
- Face Recognition and Perception
- Sleep and Work-Related Fatigue
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Nutrition, Genetics, and Disease
- Advanced MRI Techniques and Applications
- Personality Disorders and Psychopathology
- Cognitive and developmental aspects of mathematical skills
National Institute of Mental Health
2015-2025
National Center of Neurology and Psychiatry
2015-2025
Kyoto University
2023
Shimane University
2020
Gunma University Hospital
2015
Gunma University
2015
RMIT University
2014
Imaging Center
2013
Harvard University
2010-2013
Massachusetts General Hospital
2010-2013
Empathy is a concept central to psychiatry, psychotherapy and clinical psychology. The construct of empathy involves not only the affective experience other person's actual or inferred emotional state but also some minimal recognition understanding another's state. It proposed, in light multiple levels analysis including social psychology, cognitive neuroscience neuropsychology, model that both bottom-up top-down information processing underpinned by parallel distributed computational...
Because awareness of emotional states in the self is a prerequisite to recognizing such others, alexithymia (ALEX), difficulty identifying and expressing one's own states, should involve impairment empathy. Using functional magnetic resonance imaging (fMRI), we compared an ALEX group (n = 16) non-alexithymia (non-ALEX) 14) for their regional hemodynamic responses visual perception pictures depicting human hands feet painful situations. Subjective pain ratings empathy-related psychological...
Although evening preference has recently been identified as a risk factor for depression, it not substantiated whether is direct depressive states, or if associated secondarily through other factors, such delayed sleep timing and shortened duration. The objective of this study to investigate associations in Japanese adult subjects between incidence adjusting various parameters related states. Morningness-Eveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index (PSQI), Center...
Studies in psychiatry and cognitive neuroscience have reported an important relationship between individual interoceptive accuracy anxiety level. This indicates that greater attention to one's bodily state may contribute the development of intense negative emotions disorders. We hypothesized reactivity anterior insular cortex underlies intensity awareness anxiety. To elucidate this triadic mechanism, we conducted functional magnetic resonance imaging (fMRI) mediation analyses examine...
Objectives Sleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness psychomotor impairment. However, the neural basis of instability due sleep has yet be elucidated. This study investigated changes responses that are elicited by simulation short-term loss brain regions responsible for these changes. Subjects Methods Fourteen healthy adult men aged 24.1±3.3 years (range, 20–32 years) participated a within-subject crossover consisting...
Some theories of emotion emphasise a close relationship between interoception and subjective experiences emotion. In this study, we used facial expressions to examine whether interoceptive sensibility modulated emotional experience in social context. Interoceptive was measured using the heartbeat detection task. To estimate individual sensitivity, made morphed photos that ranged neutral an expression (i.e., anger, sadness, disgust happy). Recognition rates particular emotions from these were...
Alexithymia refers to difficulty in identifying and expressing one's emotions, it is related disturbed emotional regulation. It was originally proposed as a personality trait that plays central role psychosomatic diseases. This review of neuroimaging studies on alexithymia suggests associated with reduced neural responses stimuli from the external environment, well activity during imagery, limbic paralimbic areas (i.e., amygdala, insula, anterior/posterior cingulate cortex). In contrast,...
Abstract In this study, we hypothesized that dynamics of sleep time obtained over consecutive days extended in a laboratory reflect an individual’s optimal duration (OSD) and the difference between OSD habitual (HSD) at home represents potential debt (PSD). We found varies among individuals PSD showed stronger correlation with subjective/objective sleepiness than actual time, interacting vulnerability loss. Furthermore, only 1 h takes four to recover their level. Recovery from was also...
Abstract Although brain morphological abnormalities have been reported in anorexia nervosa (AN), the reliability and reproducibility of previous studies were limited due to insufficient sample sizes, which prevented exploratory analysis whole as opposed regions interest (ROIs). Objective was identify AN association with severity by structural magnetic resonance imaging (MRI) a multicenter study, conduct brain. Here, we conducted cross-sectional study using T1-weighted (T1WI) data collected...
The catechol-O-methyl transferase (COMT) gene is considered to be a promising schizophrenia susceptibility gene. A common functional polymorphism (Val158Met) in the COMT affects dopamine regulation prefrontal cortex (PFC). Recent studies suggest that this contributes poor functions, particularly working memory, both normal individuals and patients with schizophrenia. However, possible morphological changes underlying such impairments remain clarified. aim of study was examine whether...
The construct validity of alexithymia and its assessment using the 20-item Toronto Alexithymia Scale (TAS-20) in Japan is unknown. Low reliability has been found for third factor TAS-20 some cultures, structure psychosomatic disorder patients not adequately investigated. Although most likely certain developmental aspects, this infrequently investigated.The newly-developed Japanese was administered to a normative sample (n = 2,718; 14-84 y.o.), along with NEO Five-Factor Inventory (NEO-FFI)...
Abstract Theory of mind (ToM) refers to the ability attribute independent mental states, such as beliefs, preferences and desires, self others. Neuroimaging studies normal adults have consistently demonstrated importance particular brain regions for ToM, superior temporal sulcus (STS), pole (TP) medial prefrontal cortex (MPFC). However, there are little data showing how ToM develops during childhood adolescence. Such important understanding development social functioning its disorders. The...
The insular cortex has been considered to be the neural base of visceral sensation for many years. Previous studies in psychology and cognitive neuroscience have accumulated evidence indicating that interoception is an essential factor subjective feeling emotion. Recent neuroimaging demonstrated anterior activation associated with accessing interoceptive information underpinning experience emotional state. Only a small number focused on influence damage emotion processing awareness....
The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to portion of anterior cingulate (ACC) is implicated anxiogenesis hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred connectivity (FC) affects anxiety cortisol concentrations everyday life. Here, we investigate relationship between daily (dCOR) FC during emotional processing forty-one healthy humans....
The immune system has major roles in the brain and related psychopathology. Disrupted interleukin-6 secretion aberrant amygdala emotional reactivity are well-documented stress-related mental disorders. regulates psychosocial affected by genes. These led us to comprehensively examine relationship between interleukin-6, activity, symptoms under gene-stressor interactions.One hundred eight nonclinical participants with various levels of anxiety/depression underwent magnetic resonance imaging...
We performed fMRI measurements in normal children to clarify which cortical areas are commonly involved the mirror system (MS) and mentalizing, specific for whether have same neural networks MS mentalizing as adults. Normal had Common activations were found superior temporal sulcus fusiform gyri, whereas activation was medial prefrontal, pole inferior parietal cortices. suggest that might evolve from a capacity detect motion of agents infer intentions. Further, require self-perspectives.
Different regions of brain activation, as measured by fMRI, were evident in Japanese and Caucasian individuals observing facial expressions categorized fearful according to Ekman criteria. Activation was the posterior cingulate, supplementary motor cortex amygdala Caucasians, while activation right inferior frontal, premotor left insula individuals. The results suggest that Caucasians respond faces a more direct, emotional way, whereas do not attach an valence therefore activate template...
Abstract The mirror neuron system (MNS) is considered crucial for human imitation and language learning provides the basis development of empathy mentalizing. Alexithymia (ALEX), which refers to deficiencies in self‐awareness emotional states, has been reported be associated with poor ability various aspects social cognition such as mentalizing, cognitive empathy, perspective‐taking. Using functional magnetic resonance imaging (fMRI), we measured hemodynamic signal examine whether there are...
People believe that women are more emotionally intense than men, but the scientific evidence is equivocal. In this study, we tested novel hypothesis men and differ in neural correlates of affective experience, rather intensity activity, with being internally (interoceptively) focused externally (visually) focused. Adult (n = 17) completed a functional magnetic resonance imaging study while viewing affectively potent images rating their moment-to-moment feelings subjective arousal. We found...
Evidence is accumulating for the presence of cognitive impairment in patients with major depressive disorder (MDD). The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder Japan (PERFORM-J) study a 6-month, non-interventional, prospective, multicenter, epidemiological study. Using baseline data, relationship between symptoms and psychosocial function was analyzed Japanese MDD.A total 518 outpatients (aged 18-65 years) MDD initiating new...