A5025793368- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Youth Substance Use and School Attendance
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Restless Legs Syndrome Research
- Spaceflight effects on biology
- Child Nutrition and Feeding Issues
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Olfactory and Sensory Function Studies
- Infant Development and Preterm Care
- Pharmacological Effects and Toxicity Studies
- Heart Rate Variability and Autonomic Control
- Health disparities and outcomes
- Mental Health Treatment and Access
Akita University
2006-2025
National Institute of Mental Health
2015-2024
National Center of Neurology and Psychiatry
2015-2024
Institut de Recherche contre les Cancers de l’Appareil Digestif
2024
Hakodate Central General Hospital
2023
Kyoto University
2022
Nihon University
2022
Tsukuba International University
2019-2021
University of Tsukuba
2019-2021
University Hospital Carl Gustav Carus
2018
Fourteen inpatients with dementia showing sleep and behavior disorders (average age = 75 years), 10 control elderly people years) were carefully observed for 2 months. Four weeks of morning light therapy markedly improved in the group. The measurement time serum melatonin values suggests that group are related to decreases amplitude sleep-wake rhythm levels secretions. Morning significantly increased total nocturnal decreased daytime time. These results indicate bright is a powerful...
Abstract Sleep timing is influenced by the circadian system. Morningness‐eveningness (ME) preference in humans affected free‐running period, which determined clock‐relevant genes. In this study, we investigated association between 3111T/C polymorphism 3′‐flanking region of hClock (Homo sapiens Clock homolog) and ME 421 Japanese subjects. The Horne–Ostberg questionnaire (MEQ) scores showed normal distribution, with mean score 51.2 ± 1.4 (range, 25–73), were positively correlated sleep onset...
Although evening preference has recently been identified as a risk factor for depression, it not substantiated whether is direct depressive states, or if associated secondarily through other factors, such delayed sleep timing and shortened duration. The objective of this study to investigate associations in Japanese adult subjects between incidence adjusting various parameters related states. Morningness-Eveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index (PSQI), Center...
The pineal hormone melatonin has some circadian regulatory effects and is assumed to have a close relation with sleep initiation maintenance. Many previous reports described age-related decreases in levels, especially elderly insomniacs (EIs), which may act as causal or exacerbating factors disturbances the elderly. Ten residents psychophysiological insomnia (mean age, 74.2 yr), 10 healthy of same home [elderly control (EC) group; mean 72.7 yr], young subjects 20.9 yr) living at participated...
A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information maximize potency minimize toxicity during drug administration respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood from samples taken at only few points. Here applied this molecular-timetable concept evaluate humans. We constructed 1.5-d reference oscillating...
Objectives Sleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness psychomotor impairment. However, the neural basis of instability due sleep has yet be elucidated. This study investigated changes responses that are elicited by simulation short-term loss brain regions responsible for these changes. Subjects Methods Fourteen healthy adult men aged 24.1±3.3 years (range, 20–32 years) participated a within-subject crossover consisting...
Circadian rhythms in elderly patients with severe dementia and behavioral disorders such as wandering, agitation and/or delirium were examined. The subjects consisted of 24 (5 senile Alzheimer's type 19 multi-infarct dementia), aged 56-89 (means = 75.5 +/- 8.7) 8 control without or slight degree, 65-81 75 5.4). sleep-wake state the was judged every hour by nurses over periods 1-4 mo recorded form a sleep diary. Oral temperature for 4-7 consecutive days. For treatment rhythm disorders, social...
To assess circadian preference with a score, the Morningness-Eveningness Questionnaire (MEQ) has been used for more than 3 decades now. More recently, Munich ChronoType (MCTQ) was developed: it asks sleep-wake behavior on work and free days uses midpoint of sleep (MSF), corrected debt accumulated during week as an indicator chronotype (MSFsc). In this study, we developed Japanese version MCTQ by using translation/back-translation approach including examination its semantic validity....
A system of self-sustained biological clocks controls the 24-h rhythms behavioral and physiological processes such as sleep–wake cycle. The circadian clock is regulated by transcriptional translational negative feedback loops multiple genes. Polymorphisms in genes have been associated with morningness–eveningness (diurnal) preference, familial advanced sleep phase type (ASPT) delayed (DSPT). We genotyped single-nucleotide polymorphisms 182 DSPT individuals, 67 free-running (FRT) individuals...
Abstract In this study, we hypothesized that dynamics of sleep time obtained over consecutive days extended in a laboratory reflect an individual’s optimal duration (OSD) and the difference between OSD habitual (HSD) at home represents potential debt (PSD). We found varies among individuals PSD showed stronger correlation with subjective/objective sleepiness than actual time, interacting vulnerability loss. Furthermore, only 1 h takes four to recover their level. Recovery from was also...
Abstract Background We aimed to estimate the prevalence of depressive symptoms as well suicide-related ideation among Japanese university students during stay-home order necessitated by coronavirus disease 2019 pandemic in Japan, and offer evidence support future intervention depression suicide prevention strategies college students. Methods The data for this cross-sectional study were derived from Student Mental Health Survey conducted May 20 June 16, 2020 at a national Akita prefecture....
The prevalence of sleep disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence obstructive apnea (OSA) higher than previously believed, with patients having moderate-to-severe OSA accounting for approximately 20% adult males and 10% postmenopausal women not only in Western countries but also Eastern countries, including Japan. Since 1998, when health insurance coverage became available, number using continuous positive airway pressure (CPAP) therapy has increased...
Vitamin B12 (VB12) was administered to two patients suffering for many years from different sleep-wake rhythm disorders. One patient a 15-year-old blind girl free-running (hypernychthemeral syndrome) with period of about 25 h. In spite repeated trials entrain her cycle the environmental 24-h rhythm, freerunning persisted 13 years. When she 14 old, administration VB12 per os started at daily dose 1.5 mg t.i.d. Shortly thereafter, entrained and maintained while on medication. Within 2 months...
This study aimed to develop an algorithm for determining sleep/wake states by using chronological data on the amount of physical activity (activity intensity) measured with FS-750 actigraph, a device that can be worn at waist, allows its downloaded home, and is suitable use in both sleep research remote medicine. Participants were 34 healthy young adults randomly assigned two groups, A (n =17) B =17), who underwent 8-hour polysomnography (PSG) laboratory environment. Simultaneous obtained...
Pharmacologic treatments are available to treat insomnia, a common and burdensome sleep disorder, but may be contraindicated in older adults who prone side effects from sleep-promoting drugs. These analyses of diary data Study E2006-G000-303 (Study 303) investigated the benefits lemborexant 5 mg (LEM5) 10 (LEM10) subgroup age ≥ 65 years with insomnia. 303, 12-month, double-blind study LEM5 LEM10 (age 18 years) insomnia disorder (sleep onset and/or maintenance difficulties) assessed...
The authors compared the therapeutic effect of morning bright and dim light exposure on rest-activity (R-A) rhythm disorders in patients with vascular dementia (VD) Alzheimer's type (DAT). Participants this study were 12 VD (M/F = 5/7; average age 81 years) 10 DAT 4/6; 78 years). They exposed to 2 weeks (BL; 5000-8000 lux) (DL; 300 (09:00-11:00) a randomized crossover design which 2-week treatment period took place between pretreatment (1 week) posttreatment periods. Continuous R-A...