A5063576068- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Tracheal and airway disorders
- High Altitude and Hypoxia
- Lung Cancer Treatments and Mutations
- Neuroendocrine regulation and behavior
- Neonatal Respiratory Health Research
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Syncope and Autonomic Disorders
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Gastroesophageal reflux and treatments
- Circadian rhythm and melatonin
- Fatty Acid Research and Health
- Sarcoidosis and Beryllium Toxicity Research
Nara Medical University
2014-2024
Nara Medical University Hospital
2012-2024
Footscray Hospital
2022-2023
La Jolla Alcohol Research
2022-2023
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
RELX Group (United States)
2022-2023
Hamilton Health Sciences
2022-2023
Dialyse Centrum Groningen
2022-2023
Cooperative Trials Group for Neuro-Oncology
2022-2023
The prevalence of sleep disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence obstructive apnea (OSA) higher than previously believed, with patients having moderate-to-severe OSA accounting for approximately 20% adult males and 10% postmenopausal women not only in Western countries but also Eastern countries, including Japan. Since 1998, when health insurance coverage became available, number using continuous positive airway pressure (CPAP) therapy has increased...
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We investigated whether the carotid-artery intimamedia thickness (IMT) measured by ultrasonography, which is regarded as an indicator of atherosclerosis, was associated with severity obstructive sleep apnea (OSA).Cross-sectional study.A laboratory in a general hospital Japan.A total 167 patients referred to our for screening or treatment OSA were investigated. They had no history chronic pulmonary disease, cerebrovascular cardiovascular disease.NA.Obstructive diagnosed polysomnography....
Background Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor of cardiovascular events. However, the precise mechanism linking two has not been fully elucidated. Objective The aim this study was investigate effect hypoxic stress on production tumor necrosis (TNF)-α, monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-9 (MMP-9) by monocytes. Methods Thirty-three OSAS patients 13 healthy control subjects were enrolled. classified as mild-to-moderate (13)...
<i>Background:</i> Leptin levels have been reported to be higher in patients with obstructive sleep apnea (OSA) than control subjects matching age and body mass index (BMI). Although animal studies shown that leptin augments hypercapnic ventilatory response (HCVR), the effect of on HCVR has not clarified OSA. <i>Objectives:</i> To investigate whether could augment during wakefulness <i>Methods:</i> Of 134 consecutive OSA, 13 eucapnic 16 12 matched for sex,...
Buspirone, a partial agonist of the serotonergic 5-HT1A receptor, improves breathing irregularities in humans with Rett syndrome or brain stem injury. The purpose this study was to examine whether buspirone alters posthypoxic ventilatory behavior C57BL/6J (B6) and A/J mouse strains. Measurements were collected from unanesthetized adult male mice (n=6 for each strain) using plethysmographic method. Mice given intraperitoneal injections vehicle several doses exposed 2 min hypoxia (10% O2)...
Abstract Background and objective Exacerbations of chronic obstructive pulmonary disease ( COPD ) are a major cause morbidity, mortality reduced health status. Thus, to predict prevent exacerbations is essential for the management . The aims this study were determine whether nutritional status as assessed by M ini N utritional A ssessment S hort‐ F orm MNA ‐ SF predicts exacerbation compare ability with that T est CAT ). Methods Pulmonary function, modified Medical Research Council (m MRC...
Among international cardiologists it is unclear whether equipoise exists regarding the benefit of diagnosing and managing obstructive sleep apnea (OSA) to improve atrial fibrillation (AF) outcomes clinical practice are linked.Between January 2019 June 2020 we distributed a web-based 12-question survey OSA AF management practicing in 16 countries.The United States, Japan, Sweden, Turkey accounted for two-thirds responses. 863 responded; half were general cardiologists, quarter...
Abstract There have been several reports of drug‐induced lung injury caused by molecular‐targeted agents. Additionally, medical history interstitial disease and chest irradiation are established risk factors for the development progression injury. Moreover, presence fibrosis on computed tomography before treatment is a predictive factor appearance pneumonia induced anticancer drugs. Accordingly, patients with or pneumonitis were excluded from clinical trials dabrafenib trametinib combination...
ABSTRACT Background and objective: Obstructive sleep apnoea syndrome (OSAS) is known to be a risk factor for cardiovascular events. However, the precise mechanism has not been fully elucidated. OSAS‐induced hypoxic stress may promote production of inflammatory cytokines chemokines by monocytes, which crucial role in development atherosclerosis. In addition, adhesion vascular endothelium transendothelial migration monocytes are considered induce The aim this study was investigate effects on...
Abstract The prevalence of sleep-disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence obstructive sleep apnea (OSA) higher than previously believed, with patients having moderate-to-severe OSA accounting for approximately 20% adult males and 10% postmenopausal women not only in Western countries but also Eastern countries, including Japan. Since 1998, when health insurance coverage became available, number using continuous positive airway pressure (CPAP) therapy has...
Acetazolamide (Acz), a carbonic anhydrase inhibitor, is used to manage periodic breathing associated with altitude and heart failure. We examined whether Acz would alter posthypoxic ventilatory behavior in the C57BL/6J (B6) mouse model of recurrent central apnea. Experiments were performed unanesthetized, awake adult male B6 mice (n = 9), was measured using flow-through whole body plethysmography. Mice given an intraperitoneal injection either vehicle or (40 mg/kg), 1 h later they exposed...