A5103013314- Diamond and Carbon-based Materials Research
- Advanced Surface Polishing Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metal and Thin Film Mechanics
- Tunneling and Rock Mechanics
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Nutrition and Health in Aging
- Asthma and respiratory diseases
- Powder Metallurgy Techniques and Materials
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Advanced materials and composites
- Mycobacterium research and diagnosis
- Advanced machining processes and optimization
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Magnetism in coordination complexes
- Body Composition Measurement Techniques
- Tracheal and airway disorders
- Advanced ceramic materials synthesis
- Metallurgy and Material Forming
- Ion-surface interactions and analysis
Nara Medical University
2013-2024
Japan Atomic Energy Agency
1987-2024
Asahikawa Medical University
2021
Hitachi (Japan)
2010-2014
Industrial Research Institute of Shizuoka Prefecture
2013
Nara Medical University Hospital
2012
University of Shiga Prefecture
2008
IRYO Sosei University
2007
National Center For Child Health and Development
2003
Kyoto Pharmaceutical University
1993-1998
We have investigated the structure and electronic properties of graphite nanoparticles prepared by heat treating diamond nanoparticles. The nanographite forms a polyhedron with hollow in its inside, whose faces comprise stacking 3--6 planar graphene sheets an in-plane size 7--8 nm intersheet distance 0.353 nm. large suggests considerably reduction interlayer interaction compared to case bulk regular graphite. Electron-spin-resonance magnetic-susceptibility measurements show that there is...
Background Pulmonary cachexia is common in advanced chronic obstructive pulmonary disease (COPD), culminating exercise intolerance and a poor prognosis. Ghrelin novel growth hormone (GH)-releasing peptide with GH-independent effects. The efficacy safety of adding ghrelin to rehabilitation (PR) cachectic COPD patients were investigated. Methodology/Principal Findings In multicenter, randomized, double-blind, placebo-controlled trial, 33 randomly assigned PR intravenous (2 µg/kg) or placebo...
Diamond films are synthesized by arc discharge plasma jet chemical vapor deposition in the methane atmosphere. The apparatus developed generates a stabilized continuously for more than 12h. consists of hydrogen and argon. is used as an atmospheric gas mixed into jet. sprayed onto cool‐down substrate, diamond film deposited on substrate surface. By means this method, molybdenum at growth rate 930 μm/h. crystallinity measures well x‐ray diffraction Raman spectroscopy. weight obtained method...
Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause positive energy balance by reducing fat use and stimulating food intake. This study investigated whether plasma ghrelin is associated with clinical parameters in patients chronic obstructive pulmonary disease. Plasma was measured 50 13 control subjects, together anabolic catabolic factors. Patients were divided into two groups based on body mass index: underweight (n = 26) or normal weight 24). significantly higher...
Cigarette smoke has been known to affect the development of bowel disease. However it not fully elucidated how cigarette effects on gut. In this context we evaluated only caecal levels organic acids but also populations micro-flora and pH in contents after exposing rats (n = 5) for a 4-week order investigate whether gut environment is altered by or not. After exposure smoke, such as acetic acid, propionic butyric acid valeric significantly decreased. Additionally population Bifidobacterium...
Background Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor of cardiovascular events. However, the precise mechanism linking two has not been fully elucidated. Objective The aim this study was investigate effect hypoxic stress on production tumor necrosis (TNF)-α, monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-9 (MMP-9) by monocytes. Methods Thirty-three OSAS patients 13 healthy control subjects were enrolled. classified as mild-to-moderate (13)...
An 81-year-old woman presented to our hospital due an abnormal shadow on a chest X-ray and 4-week-old persistent cough. Laboratory examination revealed increased serum eosinophils immunoglobulin E. The Asthma Control Test (ACT) score forced expiratory volume in 1 sec indicated airway obstruction. Chest computed tomography (CT) mucoid impaction the dilated left-lingular lobar bronchus. She was diagnosed with bronchial asthma treated high-dose inhaled corticosteroid/long-acting β2 agonist. Two...
<i>Background:</i> Leptin levels have been reported to be higher in patients with obstructive sleep apnea (OSA) than control subjects matching age and body mass index (BMI). Although animal studies shown that leptin augments hypercapnic ventilatory response (HCVR), the effect of on HCVR has not clarified OSA. <i>Objectives:</i> To investigate whether could augment during wakefulness <i>Methods:</i> Of 134 consecutive OSA, 13 eucapnic 16 12 matched for sex,...
Pulmonary fibrosis is a progressive lung disorder characterized by interstitial fibrosis, for which no effective treatments are available. Chondroitin sulfate proteoglycan (CSPG) has been shown to be mediator, but the specific component of glycosaminoglycan chains CSPG not explored. We show that chondroitin E-type (CS-E) involved in fibrogenesis. Small interfering RNA (siRNA) targeting carbohydrate sulfotransferase 15 (CHST15) was designed inhibit CHST15 mRNA and its product, CS-E. CS-E...
Systemic inflammation is present in chronic obstructive pulmonary disease (COPD). A whey peptide-based enteral diet reduce patients with COPD, but its effect on COPD development has not been determined. On the other hand, it known that short chain fatty acids (SCFAs), which are produced by micro-flora gut, attenuates bronchial asthma mice model. Mice elastase-induced emphysema were fed 1 of 3 diets (control diet, or standard diet) to determine effects and cecal SCFAs. The group exhibited...
As a continuing study on the evaluation of various Zingiberis Rhizoma and chemical characterization processing, quantitative method by high performance liquid chromatography (HPLC) for 6, 8, 10-gingerol (1, 2, 3), 8-shogaol (4, 5), 6-dehydrogingerdione (6), galanolactone (7) has been developed. By use this HPLC method, contents these compound in twenty kinds [originating China, Taiwan, Vietnam, Japan (Shizuoka Prefecture)] fresh ginger root cultivated Shizuoka Prefecture were examined. It...