A5088085145- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Cardiovascular and Diving-Related Complications
- Heart Rate Variability and Autonomic Control
- Tracheal and airway disorders
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Health, Environment, Cognitive Aging
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Hormonal and reproductive studies
- Sleep and Work-Related Fatigue
- Functional Brain Connectivity Studies
- Forensic Toxicology and Drug Analysis
- Eating Disorders and Behaviors
- Fatty Acid Research and Health
- Infant Health and Development
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroendocrine regulation and behavior
- Nutritional Studies and Diet
Woolcock Institute of Medical Research
2016-2025
Macquarie University
2023-2025
National Health and Medical Research Council
2012-2025
Government of Western Australia Department of Health
2024-2025
The University of Sydney
2015-2024
Department of Medical Sciences
2024
Cooperative Trials Group for Neuro-Oncology
2022-2023
Dialyse Centrum Groningen
2022-2023
Saskatoon Medical Imaging
2022-2023
Footscray Hospital
2022-2023
<h3>Rationale and objectives</h3> Impaired insulin sensitivity (ISx), increased visceral abdominal fat (VAF) liver are all central components of the metabolic syndrome characteristics men with obstructive sleep apnoea (OSA). The reversibility these observed changes continuous positive airway pressure (CPAP) treatment in OSA has not been systematically studied a randomised sham-controlled fashion. <h3>Methods</h3> 65 without diabetes who were CPAP naïve had moderate to severe (age=49±12...
The combination of male gender, obstructive sleep apnoea (OSA) and obesity magnifies cardiometabolic risk. There has been no systematic study evaluating whether testosterone therapy can improve health in obese men with OSA by improving body composition, visceral abdominal fat insulin sensitivity.To assess compositional effects treatment severe OSA.An 18-week randomised, double-blind, placebo-controlled parallel group trial 67 men.Participants (age=49 ± 12 years, hypopnoea index=39.9 17.7...
High doses of short-term testosterone have been shown to acutely worsen sleep-disordered breathing in men with obstructive sleep apnoea (OSA). The effects lower, near-conventional obese OSA may differ over the longer term but not systematically studied. We assessed and treatment as an adjunct weight loss severe OSA.An 18-week randomized, double-blind, placebo-controlled, parallel group trial 67 men.All subjects were placed on a hypocaloric diet then received intramuscular injections 1000 mg...
Summary Objective Acutely restricting sleep worsens insulin sensitivity in healthy individuals whose usual is normal duration and pattern. The effect of recovery or weekend ‘catch‐up’ on metabolically active hormones with chronic restriction who regularly at weekends as yet unstudied. Design 19 men (mean ± SEM age 28·6 2·0 years, BMI 26·0 0·8 kg/m 2 ) least 6 months’ history (5·1 0·9 years) lifestyle‐driven, restricted during the working week (373 6·6 min/night) regular (weekend extension...
There is emerging evidence that obstructive sleep apnea (OSA) a risk factor for preclinical Alzheimer's disease (AD). An American Thoracic Society workshop was convened included clinicians, basic scientists, and epidemiologists with expertise in OSA, cognition, dementia, the overall objectives of summarizing state knowledge field, identifying important research gaps, potential directions future research. Although currently available cognitive screening tests may allow identification...
Abstract This comprehensive review delves into the potential of intranasal insulin delivery for managing Alzheimer's Disease (AD) while exploring connection between AD and diabetes mellitus (DM). Both conditions share features signalling dysregulation oxidative stress that accelerate inflammatory response. Given physiological barriers to brain drug delivery, including blood-brain barrier, administration emerges as a non-invasive alternative. Notably, has shown neuroprotective effects,...
Background: Cannabidiol (CBD), a major cannabinoid of Cannabis sativa, is widely consumed in prescription and non-prescription products. While CBD generally considered ‘non-intoxicating’, its effects on safety-sensitive tasks are still under scrutiny. Aim: We investigated the driving performance. Methods: Healthy adults ( n = 17) completed four treatment sessions involving oral administration placebo, or 15, 300 1500 mg randomised, double-blind, crossover design. Simulated performance was...
Summary We recently showed that testosterone therapy worsens sleep‐disordered breathing at 6–7 weeks, but not after 18 in men with obstructive sleep apnea. Changes ventilatory chemoreflexes may be responsible. The effect of on apnea has been systematically studied before. Twenty‐one obese apnea, a subgroup our recent report, were randomised an 18‐week, randomised, double‐blind, placebo‐controlled, parallel group trial to three intramuscular injections (0, 6, 12 weeks) either 1000 mg...
Abstract Background Depression is common in older people and associated with underlying brain change increasing the risk of dementia. Sleep disturbance frequently reported by those lifetime depression, however whether circadian misalignment also exists unclear. We aimed to examine rhythms sleep associations patients without depression. Methods Thirty-four meeting DSM-IV criteria for major depression (mean age = 63.9 years), 30 healthy controls 65.7 years) were recruited. Participants...
Untreated obstructive sleep apnea (OSA) is associated with cognitive deficits and altered brain electrophysiology. We evaluated the effect of continuous positive airway pressure (CPAP) treatment on quantitative electroencephalogram (EEG) measures function.We studied 167 patients OSA (age 50 ± 13, AHI 35.0 26.8) before after 6 months CPAP. Cognitive tests assessed working memory, sustained attention, visuospatial scanning, executive function. All participants underwent overnight...
While alterations in rest-activity rhythms are common older adults 'at risk' for dementia, it is unclear how relate to underlying brain integrity. Older aged > 50 years (n=143, mean age=67) with subjective and/or objective cognitive impairment underwent MRI scanning and 14-days of actigraphy. The following non-parametric measures were computed: intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), average activity during the least active 5-hour period (L5). A...