A5026721155- Dementia and Cognitive Impairment Research
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Alzheimer's disease research and treatments
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Nutritional Studies and Diet
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Down syndrome and intellectual disability research
- Advanced MRI Techniques and Applications
- Frailty in Older Adults
- Cardiovascular Health and Disease Prevention
- Sleep and Work-Related Fatigue
- Cardiovascular Disease and Adiposity
New York University
2016-2025
NYU Langone Health
2012-2024
Nathan Kline Institute for Psychiatric Research
2017-2024
Cornell University
2014-2024
Weill Cornell Medicine
2024
University of Gothenburg
2024
New York University Florence
2024
Alzheimer’s Disease Neuroimaging Initiative
2014-2024
Hinge Health
2024
Ricardo Prague (Czechia)
2024
To examine whether the presence of sleep-disordered breathing (SDB) is associated with an earlier age at mild cognitive impairment (MCI) or Alzheimer disease (AD)-dementia onset in participants from Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We also examined continuous positive airway pressure (CPAP) use delayed decline.From ADNI cohort, 3 subsets progressively stringent criteria were created a step-wise manner. Age MCI AD-dementia was main outcome variable. Analyses...
BackgroundAlzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's individuals syndrome, but natural history biomarker changes syndrome has not been established. We characterised order timing biomarkers a population syndrome.MethodsWe did dual-centre cross-sectional study recruited through population-based health plan Barcelona (Spain) services for people intellectual disabilities Cambridge (UK). Cognitive...
This observational multimodality brain imaging study investigates emergence of endophenotypes late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort clinically and cognitively normal women age-matched men.Forty-two 40- to 60-year-old (15 asymptomatic perimenopausal by age [CNT], 13 [PERI], 14 postmenopausal [MENO]) 18 age- education-matched men were examined. All patients had volumetric MRI, 18F-fluoro-2-deoxyglucose (FDG)-PET (glucose metabolism), Pittsburgh...
To examine in a 3-year brain imaging study the effects of higher vs lower adherence to Mediterranean-style diet (MeDi) on Alzheimer disease (AD) biomarker changes (brain β-amyloid load via 11C-Pittsburgh compound B [PiB] PET and neurodegeneration 18F-fluorodeoxyglucose [FDG] structural MRI) midlife.Seventy 30- 60-year-old cognitively normal participants with clinical, neuropsychological, dietary examinations biomarkers at least 2 years apart were examined. These included 34 (MeDi+) 36...
Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in pathophysiology of Alzheimer disease (AD) comes primarily from rodent models. However, unlike rodents, which predominant extracranial CSF egress via olfactory nerves traversing cribriform plate, human pathways are not well characterized. Dynamic PET with <sup>18</sup>F‐THK5117, a tracer for tau pathology, was used to estimate ventricular time–activity as biomarker clearance. We tested 3...
Rationale: Recent evidence suggests that obstructive sleep apnea (OSA) may be a risk factor for developing mild cognitive impairment and Alzheimer's disease. However, how affects longitudinal disease is less well understood.Objectives: To test the hypothesis there an association between severity of OSA increase in amyloid burden cognitively normal elderly.Methods: Data were derived from 2-year prospective study sampled community-dwelling healthy elderly. Subjects volunteers ages 55 90,...
Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease cognitive outcomes, including the development of Alzheimer disease-related dementias. Sleep disorders such as sleep-disordered breathing (eg, obstructive apnea), other disturbances, well, some which are also considered insomnia, fragmentation, circadian rhythm extreme duration), have been associated with health. Understanding...
Apathy is an important and distressing behavioural symptom in Alzheimer's disease various neuropsychiatric disorders. Recently, diagnostic criteria for apathy have been proposed.In groups of patients suffering from different diseases, (i) to estimate the prevalence meeting proposed criteria; (ii) concurrent validity with inventory (NPI) item; (iii) identify most frequently met or sub-criteria each specific (iv) inter-observer reliability apathy.This cross-sectional, multicentric,...
Emerging evidence suggests a role for sleep in contributing to the progression of Alzheimer disease (AD). Slow wave (SWS) is stage during which synaptic activity minimal and clearance neuronal metabolites high, making it an ideal state regulate levels amyloid beta (Aβ). We thus aimed examine relationships between concentrations Aβ42 cerebrospinal fluid (CSF) measures SWS cognitively normal elderly subjects.Thirty-six subjects underwent clinical cognitive assessment, structural MRI, morning...
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying increased AD in women remain largely undetermined. Preclinical studies identified perimenopause to menopause transition, a neuroendocrine transition state unique female, as sex-specific AD. In animals, estrogenic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause. This evident hypometabolism and decline mitochondrial efficiency which...
To determine the effect of self-reported clinical diagnosis obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, P-tau) cognitively normal (NL), mild cognitive impairment (MCI), Alzheimer's disease (AD) elderly.
In a large multicentre sample of cognitively normal subjects, as function age, gender and APOE genotype, we studied the frequency abnormal cerebrospinal fluid levels Alzheimer's disease biomarkers including: total tau, phosphorylated tau amyloid-β1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex® measurements were selected for this study. Each centre sent nine new aliquots that used to measure amyloid-β1-42 in Gothenburg laboratory....