A5034019657- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Delphi Technique in Research
- Mental Health Treatment and Access
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Restless Legs Syndrome Research
- Aging, Elder Care, and Social Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Musculoskeletal pain and rehabilitation
- Electroconvulsive Therapy Studies
- Stroke Rehabilitation and Recovery
- Psychoanalysis and Psychopathology Research
- Bipolar Disorder and Treatment
- Sleep and Wakefulness Research
Centro de Investigación Biomédica en Red de Salud Mental
2015-2024
Hospital Universitario 12 De Octubre
2011-2024
Instituto de Salud Carlos III
2011-2024
Research Institute Hospital 12 de Octubre
2010-2023
Fundacion Centro De Investigacion De Enfermedades Neurologicas
2010-2022
Asociación Española de Psiquiatría del Niño y el Adolescente
2020
Universidad Complutense de Madrid
2010-2019
Biomedical Research Networking Center on Neurodegenerative Diseases
2015-2018
Fundacion CITA Alzheimer
2010-2011
Abstract Neuropsychiatric symptoms (NPS) are common in dementia and predementia syndromes such as mild cognitive impairment (MCI). NPS MCI confer a greater risk for conversion to comparison patients without NPS. older adults with normal cognition also confers of decline Mild behavioral (MBI) has been proposed diagnostic construct aimed identify an increased developing dementia, but who may or not have symptoms. We propose criteria that include the MBI framework, contrast prior definitions...
Background: Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age sustained and impactful neuropsychiatric symptoms (NPS), as precursor to cognitive decline dementia. MBI NPS any severity, which are not captured by traditional psychia tric nosology, persist for least 6 months, occur in advance or concert with mild impairment. While detection description has been operationalized International Society Advance Alzheimer's Research Treatment –...
Abstract Background: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy motivation. It thus important to revise diagnostic criteria published 2009. The main objectives were to: a) definition of apathy; b) update list dimensions; c) operationalise criteria; d) suggest appropriate assessment tools including new technologies. Methods: expert panel (N = 23) included researchers...
Pilot studies applying a humanoid robot (NAO), pet (PARO) and real animal (DOG) in therapy sessions of patients with dementia nursing home day care center.In the home, were assigned by living units, based on severity, to one three parallel therapeutic arms compare: CONTROL, PARO NAO (Phase 1) PARO, DOG 2). In center, all received Therapy held 2 days per week during 3 months. Evaluation, at baseline follow-up, was carried out blind raters using: Global Deterioration Scale (GDS), Severe Mini...
Apathy is an important and distressing behavioural symptom in Alzheimer's disease various neuropsychiatric disorders. Recently, diagnostic criteria for apathy have been proposed.In groups of patients suffering from different diseases, (i) to estimate the prevalence meeting proposed criteria; (ii) concurrent validity with inventory (NPI) item; (iii) identify most frequently met or sub-criteria each specific (iv) inter-observer reliability apathy.This cross-sectional, multicentric,...
Background: Alzheimer's disease (AD) and other forms of dementia are among the most common causes disability in elderly. Dementia is often accompanied by depression, but specific diagnostic criteria treatment approaches still lacking. This study aimed to gather expert opinions on depressed patient management reduce heterogeneity everyday practice. Methods: Prospective, multicenter, 2-round Modified Delphi survey with 53 questions regarding risk factors (11), signs symptoms (7), diagnosis...
Background: Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders associated with more rapid progression increased mortality. It is unclear to what degree existing criteria utilized clinical research practice. Objective: To establish for the diagnosis of psychosis AD. Methods: The International Society Advance Research Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) subgroup reviewed AD dementias. Through a...
Major and minor forms of depression are significant contributors to Parkinson’s disease morbidity caregiver burden, affecting up 50% these patients. Nonetheless, symptoms still underrecognized undertreated in this context due scarcity evidence and, consequently, consistent clinical guideline recommendations. Here, we carried out a prospective, multicentre, 2-round modified Delphi survey with 49 questions about the aetiopathological mechanisms (10), features connections motor nonmotor...
ABSTRACT Background: Prospective studies on the clinical progression of Alzheimer's disease (AD) and its relationship to caregiver burden are needed improve illness management use resources. Methods: This national, multicenter, observational study evaluated 1235 moderate severe AD patients under routine care in Spain. Baseline cross-sectional sociodemographic data, changes from baseline month 12 various neuropsychological tests ratings, including Blessed Dementia Scale, Mini-mental State...
ObjectiveThe study aims to determine the prevalence of undiagnosed comorbid mood disorders in patients suffering chronic musculoskeletal pain a primary care setting and identify sleep disturbances other associated factors these patients, compare use health services by with without disorders.
Introduction. Alzheimer's disease (AD) is a major threat for the well-being of an increasingly aged world population. The physiopathological mechanisms late-onset AD are multiple, possibly heterogeneous, and not well understood. Different combinations variables from several domains (i.e., clinical, neuropsychological, structural, biochemical markers) may predict dementia conversion, according to distinct pathways, in different groups subjects. Methods. We launched Vallecas Project (VP),...
ABSTRACT Background: Country-specific data on resource use and costs associated with Alzheimer's disease (AD) help inform governments about the increasing need for medical financial support as increases in prevalence. Methods: GERAS II, a prospective observational study, assessed use, costs, health-related quality of life (HRQoL) among patients AD their caregivers Spain. Community-dwelling aged ≥55 years probable AD, primary caregivers, were recruited by study investigators during routine...
Present knowledge about depression in the elderly is still scarce and often controversial, despite its high frequency impact. This article reports results most relevant conclusions of a Delphi-based consensus on geriatric promoted by Spanish Psychogeriatric Association.A 78-item questionnaire was developed 7 highly specialized psychiatrists evaluated using Modified Delphi technique two rounds answered 35 with an extensive expertise depression. The topics number questions (in brackets)...
While pain is frequently associated with unipolar depression, few studies have investigated the link between and bipolar depression. In present study we estimated prevalence characteristics of among patients depression treated by psychiatrists in their regular clinical practice. The was designed to identify factors manifestation these patients. Patients diagnosed disorder (n=121) were selected participate a cross-sectional which DSM-IV-TR criteria employed depressive episodes. asked describe...
Objective Apathy is one of the most frequent symptoms dementia, whose underlying neurobiology not well understood. The objective was to analyze correlations apathy and its dimensions with gray white matter damage in brain patients advanced Alzheimer's disease (AD). Methods setting study at Alzheimer Center Reina Sofía Foundation Research Unit. Participants include 37 nursing home moderate severe AD, 78.4% were women, mean Standard Deviation (SD) age 82.7 (5.8). Several measurements taken:...