A5003176320- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Global Maternal and Child Health
- Preterm Birth and Chorioamnionitis
- Healthcare Technology and Patient Monitoring
- Obstructive Sleep Apnea Research
- Child Nutrition and Water Access
- Vagus Nerve Stimulation Research
- Emergency and Acute Care Studies
- Medical Imaging Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Autopsy Techniques and Outcomes
- Phonocardiography and Auscultation Techniques
University of Virginia
2015-2024
Columbia University
2022-2023
TriNetX (United States)
2022-2023
VA Palo Alto Health Care System
2019-2023
Stanford University
2011-2023
Mental Illness Research, Education and Clinical Centers
2019-2023
University of Virginia Children's Hospital
2009-2023
Health Net
2023
Aurora University
2022
Aurora West Allis Medical Center
2022
The following guidelines are an interpretation of the evidence presented in 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations 1). They apply primarily to newly born infants undergoing transition from intrauterine extrauterine life, but recommendations also applicable neonates who have completed perinatal require resuscitation during first few weeks months birth. Practitioners resuscitate at birth or any time...
BackgroundSub-Saharan Africa and south Asia contributed 81% of 5·9 million under-5 deaths 77% 2·6 stillbirths worldwide in 2015. Vital registration verbal autopsy data are mainstays for the estimation leading causes death, but both non-specific focus on a single underlying cause. We aimed to provide granular contributory death stillborn fetuses deceased neonates children younger than 5 years, inform child mortality prevention efforts.MethodsThe Child Health Mortality Prevention Surveillance...
Patients in ICUs are susceptible to subacute potentially catastrophic illnesses such as respiratory failure, sepsis, and hemorrhage that present severe derangements of vital signs. More subtle physiologic signatures may be before clinical deterioration, when treatment might more effective. We performed multivariate statistical analyses bedside monitoring data identify early subclinical incipient life-threatening illness.We report a study model development validation retrospective...
Importance Socioeconomic status affects pregnancy and neurodevelopment, but its association with hospital outcomes among premature infants is unknown. The Area Deprivation Index (ADI) a validated measure of neighborhood disadvantage that uses US Census Bureau data on income, educational level, employment, housing quality. Objective To determine whether ADI associated neonatal intensive care unit (NICU) mortality morbidity in extremely infants. Design, Setting, Participants This retrospective...
Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it not clear if such events independently predict worse respiratory outcome. Objectives: To determine analysis cardiorespiratory monitoring data can unfavorable outcomes at 40 weeks postmenstrual age (PMA) other outcomes, as bronchopulmonary dysplasia 36 PMA. Methods: The Prematurity-related Ventilatory Control (Pre-Vent) study...
The Child Health and Mortality Prevention Surveillance (CHAMPS) Network programme undertakes post-mortem minimally invasive tissue sampling (MITS), together with collection of ante-mortem clinical information, to investigate causes childhood deaths across multiple countries. We aimed evaluate the overall contribution pneumonia in causal pathway death causative pathogens fatal children aged 1-59 months enrolled CHAMPS Network.
Heart rate variability (HRV) falls in humans with sepsis, but the mechanism is not well understood. We utilized a mouse model of endotoxemia to test hypothesis that cytokines play role abnormal HRV during sepsis. Adult male C57BL/6 mice underwent surgical implantation probes continuously monitor electrocardiogram and temperature or blood pressure via radiotelemetry. Administration high-dose LPS (Escherichia coli LPS, 10 mg/kg, n = 10) caused biphasic response characterized by an early...
Therapeutic hypothermia instituted within 6 h of birth has been shown to improve neurodevelopmental outcomes in term newborns with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). The majority infants who would benefit from cooling are born at centers that do not offer the therapy, and adding time for transport will result delays may lead suboptimal or no neuroprotection some patients. Our objective was evaluate effect our center's experience therapeutic on neonatal...
The autonomic nervous system plays a central role in regulation of host defense and physiological responses to sepsis, including changes heart rate variability. cholinergic anti-inflammatory response, whereby infection triggers vagal efferent signals that dampen production proinflammatory cytokines, would be predicted result increased signaling the In fact, decreased variability is widely described humans with sepsis. Our studies elucidate this apparent paradox by showing mice injected...