A5057368675- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Video Surveillance and Tracking Methods
- Neurological disorders and treatments
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- Parkinson's Disease Mechanisms and Treatments
- Advanced Vision and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Anomaly Detection Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Stability and Control of Uncertain Systems
- Cancer Treatment and Pharmacology
- Airway Management and Intubation Techniques
- Pleural and Pulmonary Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Impact on Reproduction
- Cancer Genomics and Diagnostics
- Characterization and Applications of Magnetic Nanoparticles
- Brain Tumor Detection and Classification
University of Alabama at Birmingham
2016-2025
Laboratoire d’Imagerie Biomédicale
2023-2024
University of Iowa
2024
Texas A&M University – Commerce
2023
University of Florida
2023
University of California, San Diego
2020
University of California System
2020
University of Alabama
2018
University of Wisconsin–Madison
2018
Boston University
2012-2013
The diagnosis of chronic obstructive pulmonary disease (COPD) is based on a low FEV
Background Approximately half of adults with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Chest CT scans are frequently acquired in clinical practice and present an opportunity to detect COPD. Purpose To assess the performance radiomics features COPD diagnosis using standard-dose low-dose models. Materials Methods This secondary analysis included participants enrolled Genetic Epidemiology COPD, or COPDGene, study at baseline (visit 1) 10 years after 3). was defined by a...
Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it not clear if such events independently predict worse respiratory outcome. Objectives: To determine analysis cardiorespiratory monitoring data can unfavorable outcomes at 40 weeks postmenstrual age (PMA) other outcomes, as bronchopulmonary dysplasia 36 PMA. Methods: The Prematurity-related Ventilatory Control (Pre-Vent) study...
Background The prevalence of chronic obstructive pulmonary disease (COPD) in women is fast approaching that men, and experience greater symptom burden. Although sex differences emphysema have been reported, airways not systematically characterized. Purpose To evaluate whether structural may underlie some the COPD clinical outcomes. Materials Methods In a secondary analyses multicenter study never-, current-, former-smokers enrolled from January 2008 to June 2011 followed up longitudinally...
Rationale: Bedside biomarkers that allow early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) are critically important, given the higher risk death in these infants. Objectives: We hypothesized BPD-PH have patterns intermittent hypoxemia (IH) differ from BPD without PH. Methods: conducted a matched case-control study extremely preterm 22 weeks 0 days to 28 6 born between 2018 and 2020 at University Alabama Birmingham. status was...
BACKGROUNDCurrently recommended traditional spirometry outputs do not reflect the relative contributions of emphysema and airway disease to airflow obstruction. We hypothesized that machine-learning algorithms can be trained on data identify these structural phenotypes.METHODSParticipants enrolled in a large multicenter study (COPDGene) were included. The points from expiratory flow-volume curves using deep-learning model predict phenotypes chronic obstructive pulmonary (COPD) CT, results...
To investigate local short-term neuroplasticity elicited by subthalamic, thalamic, and pallidal deep brain stimulation (DBS) for movement disorders.During DBS surgery, we delivered pairs of stimulus pulses with both circular directional leads across 90 interstimulus intervals in 17 participants recorded field potentials from unused contacts on the implanted electrode array. We removed artifact, validated neural origin underlying signals, examined plasticity as a function interval target,...
Most emphysema is believed to arise from small airways disease, but recent data suggest begets more and that its progression may be due the mechanical stress experienced by normal lung regions adjacent existing emphysema. To determine whether new arises this penumbra of mechanically affected (MAL) or disease. We co-registered inspiratory chest computed tomography (CT) scans acquired at enrollment 5 years later in 4,972 participants enrolled a multicenter cohort. Using adaptive Gaussian...
Airway remodeling in chronic obstructive pulmonary disease (COPD) is due to luminal narrowing and/or loss of airways. Existing computed tomographic metrics airway reflect only components these processes. With progressive narrowing, the ratio surface area volume (SA/V) should increase, and with predominant loss, SA/V decrease.
Active contours are very popular tools for video tracking and image segmentation. Parameterized used due to their fast evolution have become the method of choice in Sobolev context. Unfortunately, these not easily adaptable topological changes, they may sometimes develop undesirable loops, resulting erroneous results. To solve such problems, one needs an algorithm contour self-crossing detection. We propose a simple methodology via techniques from differential topology. The detection is...
Abstract The diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstration airflow obstruction. Traditional spirometric indices miss a number subjects with respiratory symptoms or structural lung imaging. We hypothesized that utilizing all data points the expiratory spirometry curves to assess their shape will improve detection mild obstruction and disease. analyzed 8307 participants enrolled in COPDGene study, derived metrics based volume-time (Parameter D), flow-volume...
Importance Neonatal mortality is a major public health concern that was potentially impacted by the COVID-19 pandemic. To prepare for future crises, it important to investigate whether pandemic–related interventions were associated with changes in neonatal mortality. Objective social distancing during pandemic higher rate. Design, Setting, and Participants This cohort study examined maternal-linked birth infant death records from National Center Health Statistics, population-level US...
This work develops a new method for vector data augmentation. The proposed applies principal component analysis (PCA), determines the eigenvectors of set training vectors machine learning (ML) and uses them to generate distilled vectors. PCA-distilled have same dimension. user chooses number be augmented A statistical approach lowest such that when original vectors, extended trains an ML classifier achieve required accuracy. Hence, novelty this study is distillation with PCA their use...
Characterisation of oxygen saturation (SpO
Background Luminal narrowing is a hallmark feature of airway remodeling in COPD, but current measures focus on wall remodeling. Quantification the natural increase cumulative cross-sectional area along length human tree can facilitate assessment narrowing. Methods We analysed trees 7641 subjects enrolled multicenter COPDGene cohort. Airway luminal tapering was assessed by estimating slope change over successive generations (T-Slope). performed multivariable regression analyses to test...
Background Chronic bronchitis (CB) is strongly associated with cigarette smoking, but not all smokers develop CB. We aimed to evaluate whether measures of structural airway disease on CT are differentially Methods In between ages 45 and 80 years, Global Initiative for Obstructive Lung Disease stages 0–4, CB was defined by the classic definition. Airway quantified (i) wall area percent (WA%) segmental airways; (ii) Pi10, square root a hypothetical 10 mm internal perimeter; (iii) total count...