A5050343530- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- High Altitude and Hypoxia
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Particle physics theoretical and experimental studies
- Primary Care and Health Outcomes
- Sleep and Wakefulness Research
- Particle Detector Development and Performance
- Healthcare Policy and Management
- Tracheal and airway disorders
- Quantum Chromodynamics and Particle Interactions
- Particle Accelerators and Free-Electron Lasers
- High-Energy Particle Collisions Research
- Distributed systems and fault tolerance
- Connective tissue disorders research
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Restraint-Related Deaths
- Ion channel regulation and function
- Advanced Data Storage Technologies
- Neonatal and fetal brain pathology
- Adolescent and Pediatric Healthcare
- Heart Rate Variability and Autonomic Control
- Infant Development and Preterm Care
University of Arkansas for Medical Sciences
2015-2024
Arkansas Children's Hospital
2012-2024
University of Liverpool
2007-2024
Indiana University Health
2024
Indiana University – Purdue University Indianapolis
2024
Mayo Clinic in Florida
2023
Mayo Clinic Hospital
2023
Oxleas NHS Foundation Trust
2023
University of Colorado Anschutz Medical Campus
2021
Johns Hopkins University
1994-2016
We present the first results of Fermilab Muon g-2 Experiment for positive muon magnetic anomaly $a_\mu \equiv (g_\mu-2)/2$. The is determined from precision measurements two angular frequencies. Intensity variation high-energy positrons decays directly encodes difference frequency $\omega_a$ between spin-precession and cyclotron frequencies polarized muons in a storage ring. ring field measured using nuclear resonance probes calibrated terms equivalent proton spin precession...
The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal to measure the last unknown lepton sector mixing angle θ13 by observing νe appearance in νμ beam. It also aims make precision measurement of known parameters, Δm232 and sin22θ23, via disappearance studies. Other goals include various cross-section measurements sterile searches. uses an intense proton beam generated J-PARC accelerator Tokai, Japan, composed beamline, near detector complex (ND280), far...
Study objectiveTo determine whether primary snoring (PS) could be distinguished from childhood obstructive sleep apnea syndrome (OSAS) by clinical history.DesignRetrospective study of history 83 children with and/or disordered breathing who were referred for polysomnography.SettingTertiary referral center; pediatric pulmonary clinic.MeasurementsWe evaluated the ability a (OSA) score and other questions about sleep, breathing, daytime symptoms to distinguish PS OSAS in children. Parents asked...
Hypertension is a common complication of obstructive sleep apnea in adults. However, hypertension has not been studied systematically children with the syndrome (OSAS). We therefore measured blood pressure (BP) during polysomnography 41 OSAS, compared to 26 primary snoring (PS). Systolic and diastolic BP were every 15 min via an appropriately sized arm cuff, using automated system. This was tolerated by without inducing arousals from sleep. Children OSAS had significantly higher than those...
The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in LHCb experiment. performance of during first years its physics operation reviewed. system operated vacuum, uses bi-phase CO2 cooling system, and sensors are moved to 7 mm from LHC beam for data taking. stability these characteristic features described, details material budget given. calibration timing processing algorithms implemented FPGAs described. fully characterised. have...
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Obstructive sleep apnea causes intermittent elevation of systemic blood pressure (BP) during sleep. To determine whether obstructive in children has a tonic effect on diurnal BP, 24-hour ambulatory was obtained from 60 with mean age 10.8 +/- 3.5 years. Thirty-nine had and 21 primary snoring. Children significantly greater BP variability wakefulness sleep, higher night-to-day systolic smaller nocturnal dipping BP. Variability arterial predicted by the desaturation, body mass, arousal indices,...
• A retrospective study of pediatric patients with obstructive sleep apnea who underwent adenotonsillectomy between 1987 and 1990 was undertaken to determine the frequency postoperative respiratory compromise if risk factors for its development could be identified. Sixty-nine less than 18 years old had polysomnographically documented were observed postoperatively in intensive care unit. Of these, 16 (23%) severe compromise, defined as intermittent or continuous oxygen saturation 70% less,...
In adults, the critical nasal pressure (Pcrit) at which upper airway collapses is higher in patients with obstructive sleep apnea syndrome (OSAS) than those primary snoring. Pediatric OSAS differs clinically from adult OSAS. We therefore compared Pcrit between prepubertal children and was determined by correlating maximal inspiratory airflow level of positive or negative applied via a mask. As we found that varied proportion to upstream (nasal) rather downstream (esophageal) changes. 1 +/- 3...
Little is known about the mechanism of death during sudden infant death. To study mechanism, we obtained data on six infants who died while a memory-equipped cardiorespiratory monitor.Waveforms respiration and heart rate trend were available for five infants; an alarm log only was sixth. These printouts reviewed with attention to time death.All born prematurely; autopsies reported cause as syndrome in three cases bronchopulmonary dysplasia others. Bradycardia, which played more prominent...
Premature birth is a major public health problem in the United States and internationally. Infants born at or before 32 weeks' gestation (2% of all births 2007) are extremely high risk for death neonatal period pulmonary, visual, neurodevelopmental morbidities with lifelong consequences including bronchopulmonary dysplasia, retinopathy prematurity, brain injury. Risks adverse outcomes increase decreasing gestational age. The economic costs to care these infants also substantial (estimated...
Study objective To determine whether allergic sensitization occurs frequently in children with habitual snoring and allergy predicts the occurrence of obstructive sleep apnea syndrome (OSAS) children. Design Prospective study 39 who were referred for polysomnography. Setting Pediatric pulmonary disorders clinic a tertiary referral center. Measurements Subjects underwent complete history physical examination. assess presence sensitization, multiantigen radioallergosorbent test (RAST) was...
Carotid body (CB) glomus cells from rat express a TASK-like background K+ channel that is believed to play critical role in the regulation of excitability and hypoxia-induced increase respiration. Here we studied kinetic behaviour single openings CB determine molecular identity 'TASK-like' channels. In outside-out patches, was inhibited >90% by reduction pH(o) 7.3 5.8. cell-attached patches with 140 mM KCl 1 Mg2+ bath pipette solutions, two main open levels conductance approximately 14 pS 32...
Summary Objective To analyze whether KCNQ 2 R201C and R201H variants, which show atypical gain‐of‐function electrophysiologic properties in vitro , have a distinct clinical presentation outcome. Methods Ten children with heterozygous, de novo or variants were identified worldwide, using an institutional review board ( IRB )–approved patient registry database. We reviewed medical records and, where possible, interviewed parents treating physicians structured, detailed phenotype inventory...
Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it not clear if such events independently predict worse respiratory outcome. Objectives: To determine analysis cardiorespiratory monitoring data can unfavorable outcomes at 40 weeks postmenstrual age (PMA) other outcomes, as bronchopulmonary dysplasia 36 PMA. Methods: The Prematurity-related Ventilatory Control (Pre-Vent) study...
Abnormal central regulation of upper airway muscles may contribute to the pathophysiology childhood obstructive sleep apnea syndrome (OSAS). We hypothesized that this was secondary global abnormalities ventilatory control during sleep. therefore compared response chemical stimuli between prepubertal children with OSAS and controls. Patients aroused at a higher[Formula: see text] (58 ± 2 vs. 60 5 Torr, P < 0.05); those highest index had arousal threshold ( r = 0.52, 0.05). The hypercapnic...
Objective The results from a recent national survey about catastrophic complications following tracheostomy revealed that the majority of events involved loss airway. Most due to airway potentially correctable deficits in caregiver education. Training simulated environment allows skill acquisition without compromising patient safety. We assessed knowledge and confidence level pediatric health care providers at large tertiary children's hospital routine emergency evaluated efficacy...
The presence of swallowing dysfunction in children without obvious risk factors remains under appreciated. Early identification and prompt initiation appropriate treatments are critical for reduction morbidities associated with dysphagia.: To describe the clinical presentations, radiologic characteristics, long-term outcomes oropharyngeal dysphagia presenting as unexplained respiratory problems. We completed a retrospective chart review all known dysphagic upon presentation to...