A5086910181- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Global Maternal and Child Health
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Bacterial Infections and Vaccines
- Maternal and Neonatal Healthcare
- Autopsy Techniques and Outcomes
- Child and Adolescent Health
- Child Nutrition and Water Access
- Cystic Fibrosis Research Advances
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Neonatal and fetal brain pathology
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
- Food Security and Health in Diverse Populations
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
South African Medical Research Council
2018-2025
University of the Witwatersrand
2016-2025
Chris Hani Baragwanath Hospital
2019-2025
National Research Foundation
2015-2024
Post Graduate Institute of Medical Education and Research
2023
Respiratory and Meningeal Pathogens Research Unit
2013-2020
Medical Research Council
2015-2020
National Health Laboratory Service
2016
Klebsiella pneumoniae causes community- and healthcare-associated infections in children adults. Globally 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) 4.95 UI: 3.62-6.57) deaths were attributed to associated with bacterial antimicrobial resistance (AMR), respectively. K. was the second leading pathogen AMR resistant bacteria. Furthermore, rise of both hospital-acquired is a concern for neonates infants who are at high risk invasive disease. There limited...
The Child Health and Mortality Prevention Surveillance (CHAMPS) Network programme undertakes post-mortem minimally invasive tissue sampling (MITS), together with collection of ante-mortem clinical information, to investigate causes childhood deaths across multiple countries. We aimed evaluate the overall contribution pneumonia in causal pathway death causative pathogens fatal children aged 1-59 months enrolled CHAMPS Network.
Malaria is a leading cause of childhood mortality worldwide. However, accurate estimates malaria prevalence and causality among patients who die at the country level are lacking due to limited specificity diagnostic tools used attribute etiologies. Accurate crucial for prioritizing interventions resources aimed reducing malaria-related mortality.
Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis. We aimed to evaluate the burden invasive early-onset (0-6 days life, EOD) late-onset (7-89 days, LOD) GBS disease subsequent neurological sequelae in infants from setting with high prevalence (29.5%) HIV among pregnant women.A case-control study was undertaken at three secondary-tertiary care public hospitals Johannesburg. Invasive cases <3 months age were identified by surveillance laboratories November 2012...
Delays in illness recognition, healthcare seeking, and the provision of appropriate clinical care are common resource-limited settings. Our objective was to determine frequency delays “Three Delays-in-Healthcare”, factors associated with delays, among deceased infants children seven countries high childhood mortality. We conducted a retrospective, descriptive study using data from verbal autopsies medical records for aged 1–59 months who died between December 2016 February 2022 six sites...
Background. Human immunodeficiency virus (HIV)-exposed infants are at increased risk of invasive Group B Streptococcus (GBS) disease; however, the reason for this susceptibility has not been characterized. Methods. We compared GBS capsular and surface-protein maternal immunoglobin G antibody concentrations cord-maternal ratios between HIV-infected HIV-uninfected mother-newborn dyads. Results. Median (µg/mL) were lower in than women serotypes Ib (P = .033) V .040); pilus island (PI)–1 .016),...
Background Globally, over 400,000 neonatal deaths in 2015 were attributed to sepsis, however, the incidence and etiologies of these infections are largely unknown low-middle income countries. We aimed determine etiology community-acquired early-onset (<72 hours age) sepsis (EOS) using culture molecular diagnostics. Methods This was a prospective observational study, which we conducted surveillance for pathogens combination blood polymerase chain reaction (PCR)-based test. Blood performed on...
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and associated with long-term pulmonary sequelae for up to 30 years after infection. The mainstay RSV management supportive therapy such as supplemental oxygen. Palivizumab (Synagis™–AstraZeneca), a monoclonal antibody targeting F protein site II, has been licensed prevention high-risk groups since 1998. There recent promising progress preventative strategies that include...
Group B streptococcus (GBS) is a major global cause of neonatal meningitis, sepsis and pneumonia, with an estimated 91,000 infant deaths per year additional 46,000 stillbirths. GBS infection in pregnancy also associated adverse maternal outcomes preterm births. As such, the World Health Organization (WHO) prioritised development vaccine suitable for use pregnant women LMICs, where burden disease highest. Several vaccines are clinical development. The WHO Defeating Meningitis by 2030 has set...
Invasive group B Streptococcus (GBS) remains a leading cause of illness and death among infants globally. We conducted prospective retrospective laboratory-based surveillance GBS-positive cultures from <3 months age in 18 hospitals across China during January 1, 2015-December 31, 2017. The overall incidence GBS was 0.31 (95% CI 0.27-0.36) cases/1,000 live births; 0-0.76 births participating hospitals. case-fatality rate 2.3%. estimated 13,604 cases 1,142 GBS-associated deaths <90 days...
Abstract From April to September 2020, we investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in a cohort of 396 healthcare workers (HCWs) from 5 departments at Chris Hani Baragwanath Hospital, South Africa. Overall, 34.6% HCWs had polymerase chain reaction–confirmed SARS-CoV-2 infection (132.1 [95% confidence interval, 111.8–156.2] per 1000 person-months); an additional 27 were identified by serology. the internal medicine department highest rate (61.7%)....
To describe the burden of calcium channel blocker (CCB) overdose at a tertiary intensive care unit (ICU). Retrospective study patients admitted to ICU with CCB from 2020 2022. Adult participants clinically confirmed overdose. Admission frequency, management strategies, and patient outcomes. A total 1719 admissions over period, 24 (1.4%) had case fatality rate 12.5% (3/24). Interventions included mechanical ventilation (MV) (71%), vasopressors (92%), high-dose insulin euglycemic therapy...
Abstract Klebsiella pneumoniae (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease death in African children; however, there no comparative genomic analysis between colonizing strains. This study investigated the relatedness KPn isolates South infants; evaluated relative invasiveness based on sequence types (ST), capsular (KL), lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less diversity amongst (22 ST, 17 K-loci) than (31...