A5076639101- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Parasitic infections in humans and animals
- COVID-19 Clinical Research Studies
- Congenital Anomalies and Fetal Surgery
- HIV/AIDS Research and Interventions
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- HIV/AIDS drug development and treatment
- Amoebic Infections and Treatments
- Pneumonia and Respiratory Infections
- HIV-related health complications and treatments
- Parasites and Host Interactions
- Nail Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Disaster Response and Management
- Long-Term Effects of COVID-19
- Healthcare Policy and Management
- Infectious Diseases and Tuberculosis
- HIV/AIDS Impact and Responses
- Mobile Health and mHealth Applications
- Global Maternal and Child Health
University of the Witwatersrand
2016-2025
Chris Hani Baragwanath Hospital
2016-2025
North Shore Hospital
2024
Johannesburg Hospital
2017
Helen Joseph Hospital
2007-2013
Amsterdam UMC Location University of Amsterdam
2011
University of Amsterdam
2011
National Health Laboratory Service
2007-2010
Polytechnic Institute of Portalegre
1995
There is little evidence comparing treatment outcomes between adolescents and other age groups, particularly in resource-limited settings. A retrospective analysis of data from seven HIV clinics across urban Gauteng (n=5) rural Mpumalanga (n=2), South Africa was conducted. The compared HIV-positive antiretroviral (ART)-naive young (10-14 years), older (15-19), adults (20-24 years) to (≥25 initiated onto standard first-line ART April 2004 August 2010. Log-binomial regression used estimate...
The Southern African Journal of HIV Medicine is focused on HIV/AIDS treatment, prevention and related topics relevant to clinical public health practice. purpose the journal disseminate original research results support high-level learning Medicine. It publishes articles, editorials, case reports/case series, reviews state-of-the-art practice correspondence.
There has been major improvement in the survival of HIV-1 infected individuals since South African Government introduced highly active anti-retroviral therapy (HAART) public sector 2004. This brought new challenges which include effects stavudine-related toxicities. Prospective analysis a cohort 9040 HIV-infected adults who were initiated on HAART at Themba Lethu Clinic (TLC) Johannesburg between April 1, 2004 to December 31, 2007, and followed up until June 30, 2008. Amongst study subjects,...
Abstract From April to September 2020, we investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in a cohort of 396 healthcare workers (HCWs) from 5 departments at Chris Hani Baragwanath Hospital, South Africa. Overall, 34.6% HCWs had polymerase chain reaction–confirmed SARS-CoV-2 infection (132.1 [95% confidence interval, 111.8–156.2] per 1000 person-months); an additional 27 were identified by serology. the internal medicine department highest rate (61.7%)....
Background. Pulmonary ultrasound techniques have historically been applied to acute lung diseases describe lesions, particularly in critical care. Objectives. To explore the role of (LUS) hospitalised patients with hypoxaemic pneumonia during COVID‐19 pandemic. Methods. This was a single‐centre prospective, observational study two groups adult pneumonia: those pneumonia, and non‐COVID‐19 community‐acquired (CAP). A pulmonologist performed bedside LUS using Bedside Lung Ultrasound Emergency...
Background. In South Africa (SA), intensive care is faced with the challenge of resource scarcity as well an increasing demand for unit (ICU) services. ICU services are expensive, and practitioners in low- to middle-income countries experience daily consequences limited resources. Critically resources necessitate that rationing triage (prioritisation) decisions frequently necessary SA, particularly publicly funded health sector. Purpose. The purpose this consensus statement examine key...
Drug-induced liver injury (DILI) in HIV/tuberculosis (TB) co-infected patients is a common problem the South African setting, and re-introduction of anti-TB drugs can be challenging for healthcare worker. Although international guidelines on TB treatment are available, definition DILI not uniform, management antiretroviral therapy (ART) HIV co-infection mentioned, guidance uniform lacks practical approach. In this consensus statement, we summarise important aspects provide workers different...
Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings high prevalence HIV Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated a positive ante-mortem PCR test and/or disease at Chris Hani Baragwanath Academic Hospital Soweto, South Africa from 15th April 2nd November 2020, during the first wave African COVID-19 epidemic, were investigated....
Anaemia is frequent in patients with human immunodeficiency virus infection, and antiretroviral drugs have been implicated. Whilst therapy-induced anaemia more readily attributed to zidovudine, lamivudine-associated, potentially life-threatening, pure red cell aplasia (PRCA) has less recognized the past only infrequently documented literature. We report on a patient suffering from what turned out be lamivudine-induced PRCA who required 15 units of blood within 3 weeks before recovering...
Objective To assess the outcomes of linkage to TB and HIV care identify risk factors for poor referral outcomes. Design Cohort study patients diagnosed at an urban hospital. Methods Linkage was determined by review clinic files, national death register, telephone contact, classified as linked care, delayed (>7 days treatment, >30 care), or failed care. We performed log-binomial regression patient characteristics associated with Results Among 593 patients, 23% treatment 30.3% 77.0% who...
Acinetobacter baumannii is a prolific nosocomial pathogen renowned for its multidrug-resistant nature. We report case of community-acquired meningitis due to A. baumannii. The highlights the potential pathogenicity this organism and raises concerns that highly adaptable may soon evolve into significant community pathogen, too.
Objectives Low‐dose stavudine therapy may have a lower toxicity profile compared with standard dose. A randomized controlled trial comparing these two doses of tenofovir disoproxil fumarate (tenofovir DF ) was performed to assess the effects on anthropometry, markers inflammation, and lipid glucose metabolism in B lack S outh frican patients. Methods Sixty patients were 1:1:1 either standard‐dose (30–40 mg) or low‐dose (20–30 (300 mg), each combined lamivudine efavirenz, for 48 weeks....
Abstract Background Sizwe Tropical Diseases Hospital is the only specialized for management of multidrug-resistant (MDR)-TB and extensively drug-resistant (XDR)-TB cases in Gauteng Province. In South Africa, there a mismatch between numbers individuals with laboratory diagnosis tuberculosis (TB) those being referred initiation specialist treatment. We determined reasons non-referral MDR-TB XDR-TB cases. Methods conducted descriptive questionnaire-based study amongst provincial primary health...