A5071935032- Dementia and Cognitive Impairment Research
- Chronic Disease Management Strategies
- Treatment of Major Depression
- Alzheimer's disease research and treatments
- Schizophrenia research and treatment
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Poisoning and overdose treatments
- Hormonal Regulation and Hypertension
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Pharmacology and Obesity Treatment
- Primary Care and Health Outcomes
- Sexual function and dysfunction studies
- Heart Failure Treatment and Management
- Pain Mechanisms and Treatments
- Psychiatric care and mental health services
- Renin-Angiotensin System Studies
- Drug-Induced Hepatotoxicity and Protection
- Alcoholism and Thiamine Deficiency
- Health Promotion and Cardiovascular Prevention
- Mental Health and Patient Involvement
- Mental Health and Psychiatry
- Healthcare Systems and Challenges
- Cardiac Health and Mental Health
Kinokuniya
2016-2023
Cambridge University Press
2016-2023
New York University Press
2016-2023
Dorking Community Hospital
2018-2023
Royal College of General Practitioners
2016-2020
Dementia UK
2016-2018
NHS England
2016-2017
University of Southampton
2016
Virgin Care
2014
Oxfordshire Clinical Commissioning Group
2013
Abstract: Alzheimer's disease is the leading cause of dementia. However, neither nor dementia are an inevitable consequence aging. This review provides overview issues involved in a diagnosis before individual meets criteria for It examines how rates can be improved, implications early individual, carer and society, importance risk reduction to prevent or delay progression. Although no disease-modifying agents capable reversing initial pathological changes currently available, it may...
Impaired sexual function is associated with major depressive disorder in the untreated state and often more prevalent during antidepressant therapy, which frequently results poor treatment compliance. In this double-blind, multicenter study, effects of agomelatine (an MT1 MT2 agonist 5HT-2C antagonist) venlafaxine XR on were compared using Sex Effects Scale depressed patients. A total 276 male female patients received either (50 mg) or (titrated to a target dose 150 mg/d) for 12 weeks. Those...
Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up terminology mild impairment (MCI). MCI heterogenous clinical syndrome reflecting change function deficits neuropsychological testing but relatively intact activities daily living. risk state further functional decline with 5-15% people developing dementia per year. However, ~50% remain stable at 5 years minority,...
A total of 147 patients who had responded in a placebo-controlled study to 6 weeks treatment an episode DSM-III-R major depression with either 20 mg or 40 citalopram were randomized double-blind continue on the same dose receive placebo during 24-week efficacy prevention relapse. The and groups showed significant advantage compared both relapses (p < 0.05) survival analysis time relapse = 0.01 p 0.02, respectively). Both appeared similarly safe well tolerated little difference side effects...
Background: Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders associated with more rapid progression increased mortality. It is unclear to what degree existing criteria utilized clinical research practice. Objective: To establish for the diagnosis of psychosis AD. Methods: The International Society Advance Research Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) subgroup reviewed AD dementias. Through a...
Keywords: nutrition, medical food, cognition, modifiable risk factors
Whilst people with intellectual disability grow older, evidence has emerged internationally about the largely unmet health needs of this specific ageing population. Health checks have been implemented in some countries to address those inequalities. Evaluations focused on measuring process outcomes due challenges quality life outcomes. In addition, cost-effectiveness is currently unknown. As part a national guideline for population we sought explore likely annual England.Decision-analytical...
Objectives Evaluate the reliability of using diagnosis codes and prescription data to identify timing symptomatic onset, cognitive assessment Alzheimer’s disease (AD) among patients diagnosed with AD. Methods This was a retrospective cohort study UK Clinical Practice Research Datalink (CPRD). The consisted random sample 50 first AD in 2010–2013. Additionally, were required have valid text-field code hospital episode or referral 3 years before diagnosis. earliest indications impairment,...
While evidence can help inform best practice, it needs to be placed in context.There may no available or applicable for a specific patient with his her own set of conditions, capabilities, beliefs, expectations and social circumstances.There are areas uncertainty, ethics aspects care which there is one right answer.General practice an art as well science.Quality also lies the nature clinical relationship, communication truly informed decision-making.The BACK TO section stimulates debate, two...
Major depression is the leading cause of ill health and disability worldwide. 2017 marked year when World Health Organization led a one‐year global campaign with goal that more people both seek get help. 1,2 In England, Hospital Episode Statistics Mental Learning Disabilities data sets show one in three patients are unrecognised. Those who recognised often then under‐treated, fail to achieve remission have difficulty returning full functioning.
The UK government is planning to introduce incentives for general practitioners check dementia in all patients aged 75 and older. <b>Jill Rasmussen</b> says that it will allow earlier support with dementia, but <b>Margaret McCartney</b> (doi:10.1136/bmj.f1745) industry has more gain than
Controlled trials show that about 80% of schizophrenic patients remain relapse free when given adequate neuroleptic maintenance therapy but this level efficacy is not achieved in clinical practice. Guidelines for proper use neuroleptics prevention were developed by a group experienced psychiatrists – the ‘Consensus Group’ 1989. In survey, views UK psychiatrists, GPs, CPNs and pharmacists involved community care schizophrenia compared with Guidelines.
O'Kelly et al. (see p21) highlight some significant issues resulting from the increased emphasis on importance of recognising dementia in people under 65 years age and impact this is having memory assessment services that are run by old mental health who usually cater for over years.
Aliskiren is the first of a new class orally active, non-peptide, renin inhibitors. The enzyme involved in step - angiotensin aldosterone system (RAAS), which helps regulate blood pressure. Inhibition activity suppresses RAAS at an earlier point than that targeted by converting (ACE) Short-term, placebo-controlled studies patients with mild-to-moderate hypertension show aliskiren monotherapy to be well tolerated and effective; it lowers pressure least as effectively diuretic...
The typical antipsychotic drugs, which have been the mainstay of treatment for schizophrenia many years, are potent antagonists D2 receptors. However, their lack selectivity receptors in mesolimbic areas compared with nigrostriatal brain has resulted an association at therapeutic doses extrapyramidal side-effects, increased risk tardive dyskinesia and prolactin levels. Together other significant this profile limited acceptability treatment, resulting poor compliance, relapse severity...
Deposition of the beta-amyloid peptide is thought to be an important initial step in progression and pathogenesis Alzheimer's disease. Amyloid beta peptides Ab1-40 Ab1-42, two major species beta-amyloid, are generated by sequential proteolytic cleavage amyloid precursor protein (APP). Studies suggest that Ab1-42 deposition essential AD which aggregates rapidly resulting plaque formation than Ab1-40. Individuals with Down's syndrome (DS) have increased levels risk AD. suggested increase...
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