A5055979380- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Medical Imaging Techniques and Applications
- Stress Responses and Cortisol
- Cardiac Arrest and Resuscitation
- Cholinesterase and Neurodegenerative Diseases
- Spatial Cognition and Navigation
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Fetal and Pediatric Neurological Disorders
- Cancer-related cognitive impairment studies
- Cardiovascular Health and Disease Prevention
Cornell University
2010-2025
Weill Cornell Medicine
2020-2025
Presbyterian Hospital
2006-2024
New York Hospital Queens
2006-2024
NewYork–Presbyterian Hospital
2006-2024
MIND Research Institute
2021-2024
Stoke-on-Trent City Council
2020
New York University
2011-2019
NYU Langone Health
2015-2018
St Vincent's Hospital
2017
Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in pathophysiology of Alzheimer disease (AD) comes primarily from rodent models. However, unlike rodents, which predominant extracranial CSF egress via olfactory nerves traversing cribriform plate, human pathways are not well characterized. Dynamic PET with <sup>18</sup>F‐THK5117, a tracer for tau pathology, was used to estimate ventricular time–activity as biomarker clearance. We tested 3...
Rationale: Recent evidence suggests that obstructive sleep apnea (OSA) may be a risk factor for developing mild cognitive impairment and Alzheimer's disease. However, how affects longitudinal disease is less well understood.Objectives: To test the hypothesis there an association between severity of OSA increase in amyloid burden cognitively normal elderly.Methods: Data were derived from 2-year prospective study sampled community-dwelling healthy elderly. Subjects volunteers ages 55 90,...
Abstract Magnetic resonance imaging (MRI) in association with Jacobian‐modulated voxel‐based morphometry (VBM) was used to test for regional variation gray matter over the menstrual cycle. T1‐weighted anatomical images were acquired using a spoiled gradient recalled acquisition sequence 21 women. Each subject scanned twice: once during postmenstrual late‐follicular phase (Days 10–12 after onset of menses), and premenstrual late‐luteal (1–5 days before menses). Gray relatively increased right...
Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) value of combining with CSF phospho-tau (P-tau) are still unclear.Plasma-tau, CSF-tau, P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) patients AD 29) recruited at NYU Center Brain Health, comprehensive neuropsychological magnetic resonance imaging evaluations.Plasma was higher than (P < .001, area under receiver...
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship not well established in living humans. CSF major feature glymphatic clearance (BGC), has been shown abnormal AD murine models. MRI phase contrast and intrathecally delivered studies have reported reduced flow AD. Using PET tau tracer 18 F-THK5117, we previously that the ventricular was associated with elevated levels....
Abstract The glymphatic system is a perivascular fluid clearance system, most active during sleep, considered important for clearing the brain of waste products and toxins. Glymphatic failure hypothesized to underlie protein deposition in neurodegenerative disorders like Alzheimer’s disease. Preclinical evidence suggests that functioning also essential recovery from traumatic injury, which involves release debris toxic proteins need be cleared brain. In cross-sectional observational study,...
Abstract INTRODUCTION Mapping of microscopic changes in the perivascular space (PVS) cerebral cortex, beyond magnetic resonance‐visible PVS white matter, may enhance our ability to diagnose Alzheimer's disease (AD) early. METHODS We used cerebrospinal fluid (CSF) water fraction (CSFF), a resonance imaging–based biomarker, characterize brain parenchymal CSF water, reflecting parenchyma. measured CSFF and amyloid beta (Aβ) using 11 C Pittsburgh compound B positron emission tomography...
ABSTRACT BACKGROUND AND PURPOSE Evidence from animal models and examination of human epilepsy surgery specimens indicates that inflammation plays an important role in epilepsy. Positron emission tomography (PET) using [C11]PK11195, a marker activated microglia, provides means to visualize neuroinflammation vivo humans. We hypothesize patients with active epilepsy, [C11]PK11195 PET (PK‐PET) may be able identify areas focally increased corresponding the seizure onset zone. METHODS A young...
Objective There is increasing evidence to suggest that diet, one of the most important modifiable environmental factors, may play a role in preventing or delaying cognitive decline and Alzheimer's disease (AD). This study examines relationship between dietary nutrients brain biomarkers AD cognitively normal individuals (NL) with without risk factors. Design As part an ongoing imaging study, participants received clinical laboratory examinations, neurocognitive test battery, positron emission...
Summary In animal models, inflammation is both a cause and consequence of seizures. Less known about the role in human epilepsy. We performed positron emission tomography ( PET ) using radiotracer sensitive to brain patient with frontal epilepsy ~36 h after seizure as well during seizure‐free period. When statistically compared group 12 matched controls, patient's scans identified (supplementary motor area) region increased corresponding his clinically defined focus, but postseizure scan...
Flortaucipir positron emission tomography (PET) scans, rated with a novel, US Food and Drug Administration-approved, clinically applicable visual interpretation method, provide valuable information regarding near-term clinical progression of patients Alzheimer disease (AD) or mild cognitive impairment (MCI). To evaluate the association between flortaucipir PET patients' progression. Two prospective, open-label, longitudinal studies were conducted from December 2014 to September 2019. Study 1...
Cerebrospinal fluid (CSF) studies consistently show that CSF levels of amyloid-beta 1–42 (Aβ42) are reduced and tau increased prior to the onset cognitive decline related Alzheimer's disease (AD). However, preclinical prediction accuracy for low Aβ42 levels, a surrogate brain deposits, is not high. Moreover, pathology data suggests course initiated by tauopathy contradicting contemporary clinical view an Aβ cascade. from 3 normal aging cohorts (45–90 years) were combined test both...
Although there is an increasing agreement that hypertension associated with cerebrovascular compromise, relationships between blood pressure (BP) and cerebral flow are not fully understood. It known what BP level, consequently therapeutic goal, optimal for brain perfusion. Moreover, limited data on how affects hippocampal perfusion, a structure critically involved in memory. We conducted cross-sectional (n=445) longitudinal (n=185) study of adults elderly without dementia or clinically...
Neuroinflammation is believed to be a key process in Alzheimer's disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed useful peripheral markers of inflammation. However, it unclear how these inflammatory relate AD pathology, such as β-amyloid (Aβ) plaques tau tangles. Using
Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed clearance implicated in Alzheimer’s disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index healthy subjects. also first time effect head size. In accord with prior studies, we show reduced aging, men compared women. However, size may be major...
Cerebrospinal fluid (CSF) measures of phosphorylated-tau (P-tau) 231 and P-tau181 are two biomarkers for the identification tau pathology as related to Alzheimer's disease (AD). While both pathologically validated, their relative diagnostic performances not well known. This cross-sectional study 87 normal (NL) subjects 28 AD compared CSF P-tau231 with P-tau181. Logistic regression modeling demonstrated that was superior in classifications. At a fixed 85% sensitivity cutoff, ROC analysis...