A5027978452- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiation Detection and Scintillator Technologies
- Radiopharmaceutical Chemistry and Applications
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Quantum Chromodynamics and Particle Interactions
- Cerebrospinal fluid and hydrocephalus
- Radiation Dose and Imaging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Head and Neck Cancer Studies
- Menopause: Health Impacts and Treatments
- CCD and CMOS Imaging Sensors
- Occupational and environmental lung diseases
- Chronic Myeloid Leukemia Treatments
Cornell University
2017-2025
Weill Cornell Medicine
2019-2025
Memorial Sloan Kettering Cancer Center
2008-2021
National Center for Cancer Care and Research
2016-2019
Hamad Medical Corporation
2017
The University of Texas MD Anderson Cancer Center
2005
Wayne State University
1999-2002
Brookhaven National Laboratory
2000
We have reported in our previous studies on the methodology, and feasibility of 4D‐PET (Gated PET) acquisition, to reduce respiratory motion artifact PET imaging thorax. In this study, we expand investigation address problem respiration PET/CT imaging. The four lung cancer patients were monitored by tracking external markers placed A 4D‐CT acquisition was performed using a “step‐and‐shoot” technique, which computed tomography (CT) projection data acquired over complete cycle at each couch...
Positron emission tomography (PET) has shown an increase in both sensitivity and specificity over computed (CT) lung cancer. However, motion artifacts the 18F fluorodioxydoglucose (FDG) PET images caused by respiration persists to be important factor degrading image quality quantification. Motion lead two major effects: First, it affects accuracy of quantitation, producing a reduction measured standard uptake value (SUV). Second, apparent lesion volume is overestimated. Both impact upon...
Purpose To describe a split-dose technique for fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT)-guided ablation that permits both target localization and evaluation of treatment effectiveness. Materials Methods Institutional review board approved the study with waiver consent. From July to December 2011, 23 patients (13 women, 10 men; mean age, 59 years; range, 35–87 years) 29 FDG-avid tumors (median size, 1.4 cm; 0.6–4.4 cm) were targeted ablation. The...
Androgen receptor-signaling inhibitor (ARSi) drugs prolong life in metastatic castration-resistant prostate cancer (mCRPC), but such tumors eventually become resistant and progress. Comprehensive positron emission tomography/computed tomography (PET/CT) imaging using fluoro-2-D-deoxyglucose F 18 ([18F]-FDG) for glycolysis (Glyc) fluorodihydrotestosterone ([18F]-FDHT) androgen receptor (AR) expression determine heterogeneity of phenotypes, which may be useful distinguishing patients who will...
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship not well established in living humans. CSF major feature glymphatic clearance (BGC), has been shown abnormal AD murine models. MRI phase contrast and intrathecally delivered studies have reported reduced flow AD. Using PET tau tracer 18 F-THK5117, we previously that the ventricular was associated with elevated levels....
We compare the consistency and accuracy of two image binning approaches used in 4D-CT imaging. One approach, phase (PB), assigns each breathing cycle 2π rad, within which images are grouped. In amplitude (AB), assigned bins according to signal's full amplitude. To quantitate both we a NEMA NU2-2001 IEC phantom oscillating axial direction at random frequencies amplitudes, approximately simulating patient's breathing. were obtained using four-slice GE Lightspeed CT scanner operating cine mode....
The recently developed GATE (GEANT4 application for tomographic emission) Monte Carlo package, designed to simulate positron emission tomography (PET) and single photon computed (SPECT) scanners, provides the ability model account effects of noncollinearity, off-axis detector penetration, size response, range, scatter, patient motion on resolution quality PET images. objective this study is validate a within General Electric (GE) Advance/Discovery Light Speed (LS) scanner. Our...
Respiratory motion during PET/CT acquisition can cause misregistration and inaccuracies in calculation of standardized uptake values (SUVs). Our aim was to compare the detection characterization thoracic lesions on with without a deep-inspiration protocol. <b>Methods:</b> We studied 15 patients suspected pulmonary who underwent clinical PET/CT, followed by breath-hold (BH) PET/CT. In BH CT, whole chest patient scanned s at end deep inspiration. For PET, were asked hold their breath 9 times...
Abstract 17β-estradiol, the most biologically active estrogen, exerts wide-ranging effects in brain through its action on estrogen receptors (ERs), influencing higher-order cognitive function and neurobiological aging. However, our knowledge of ER expression regulation by neuroendocrine aging living human is limited. This vivo 18 F-fluoroestradiol ( F-FES) Positron Emission Tomography (PET) study healthy midlife women reveals progressively higher density over menopause transition...
BACKGROUND Meningiomas are the most common primary intracranial neoplasms. Gross-total resection, treatment goal, is not achieved in up to 50% of patients, affecting progression-free and overall survival. The traditionally used intraoperative assessment resection extent using Simpson grade has recently been shown be less accurate than postoperative MRI. Improving delineation thus represents a paramount goal. Somatostatin receptor (SSTR)–targeted PET improved meningioma management....
Respiratory motion is known to affect the quantitation of FDG18 uptake in lung lesions. The aim study was investigate magnitude errors tracer activity determination due motion, and its dependence upon CT attenuation at different phases cycle. To estimate these we have compared maximum concentrations determined from PET/CT images a phantom rest under simulated respiratory motion. NEMA 2001 IEC body phantom, containing six hollow spheres with diameters 37, 28, 22, 17, 13, 10 mm, used this...