A5011869870- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Nuclear Physics and Applications
- Radiopharmaceutical Chemistry and Applications
- Sparse and Compressive Sensing Techniques
- Advanced NMR Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Lanthanide and Transition Metal Complexes
- Hepatocellular Carcinoma Treatment and Prognosis
- Digital Radiography and Breast Imaging
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Medical Imaging and Pathology Studies
- Microwave Imaging and Scattering Analysis
Memorial Sloan Kettering Cancer Center
2015-2025
Kettering University
2009-2020
IBM (United States)
2014
University of Pennsylvania
2011
The University of Texas MD Anderson Cancer Center
2011
Bucknell University
2011
Sofia University "St. Kliment Ohridski"
2010
National Research Council Canada
2010
Soroka Medical Center
2010
Klinikum Passau
2006
Monte Carlo simulation is an essential tool in emission tomography that can assist the design of new medical imaging devices, optimization acquisition protocols and development or assessment image reconstruction algorithms correction techniques. GATE, Geant4 Application for Tomographic Emission, encapsulates libraries to achieve a modular, versatile, scripted toolkit adapted field nuclear medicine. In particular, GATE allows description time-dependent phenomena such as source detector...
In this study, a measurement protocol is presented that improves the precision of dose measurements using flat-bed document scanner in conjunction with two new GafChromic® film models, HS and Prototype A EBT exposed to photon beams. We established sources uncertainties measurements, governed by calibration curve fit parameters contributions. have quantitatively assessed influence different steps on overall uncertainty. Applying described paper Agfa Arcus II scanner, one-sigma uncertainty for...
The purpose of this educational report is to provide an overview the present state-of-the-art PET auto-segmentation (PET-AS) algorithms and their respective validation, with emphasis on providing user help in understanding challenges pitfalls associated selecting implementing a PET-AS algorithm for particular application.A brief description different types provided using classification based method complexity type. advantages limitations current are highlighted publications existing...
The recently developed GATE (GEANT4 application for tomographic emission) Monte Carlo package, designed to simulate positron emission tomography (PET) and single photon computed (SPECT) scanners, provides the ability model account effects of noncollinearity, off-axis detector penetration, size response, range, scatter, patient motion on resolution quality PET images. objective this study is validate a within General Electric (GE) Advance/Discovery Light Speed (LS) scanner. Our...
The aim of this study was to develop a clinically applicable noninvasive method quantify changes in androgen receptor (AR) levels based on <sup>18</sup>F-16β-fluoro-5α-dihydrotestosterone (<sup>18</sup>F-FDHT) PET prostate cancer patients undergoing therapy. <b>Methods:</b> Thirteen underwent dynamic <sup>18</sup>F-FDHT over selected tumor. Concurrent venous blood samples were acquired for metabolite analysis. A second cohort 25 injected with the heart. These data used generate...
There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency other characteristics CR produced by various radionuclides would help accessing feasibility proposed applications guide choice radionuclides. To generate this information we developed models based on Frank-Tamm equation distribution Monte-Carlo simulations photon β particle transport. All were validated against direct measurements using multiple...
This paper systematically evaluates a pharmacokinetic compartmental model for identifying tumor hypoxia using dynamic positron emission tomography (PET) imaging with 18F-fluoromisonidazole (FMISO). A generic irreversible one-plasma two-tissue was used. PET image dataset simulated three regions—normoxic, hypoxic and necrotic—embedded in normal-tissue background, an image-based arterial input function. Each voxelized tissue's time activity curve (TAC) typical values of kinetic parameters, as...
Correcting positron emission tomography (PET) images for the partial volume effect (PVE) due to limited resolution of PET has been a long-standing challenge. Various approaches including incorporation system response function in reconstruction have previously tested. We present post-reconstruction PVE correction based on iterative deconvolution using 3D maximum likelihood expectation-maximization (MLEM) algorithm. To achieve convergence we used one step late (OSL) regularization procedure...
Purpose: The need for an accurate lesion segmentation tool in PET is a prerequisite the estimation of response to therapy, radionuclide dosimetry, and application radiotherapy planning. In this work, authors have developed iterative method based on mathematical fit deduced from Monte Carlo simulations estimate tumor thresholds. Methods: GATE software, GEANT4 tool, was used model GE Advance scanner geometry. Spheres ranging between 1 diameters were simulated high diameter cylinder. spheres...
Assessment of tumor response after chemotherapy using <sup>18</sup>F-FDG PET metrics is gaining acceptance. Several studies have suggested that the parameters metabolically active volume (MTV) and total lesion glycolysis (TLG) are superior to SUV<sub>max</sub> for measuring burden. However, measurement MTV TLG still controversial; most common method uses an absolute threshold 42% SUV<sub>max</sub>. Recently, we implemented a background-adaptive determine background-subtracted activity (BSL)...
This work describes PETSTEP (PET Simulator of Tracers via Emission Projection): a faster and more accessible alternative to Monte Carlo (MC) simulation generating realistic PET images, for studies assessing image features segmentation techniques.PETSTEP was implemented within Matlab as open source software. It allows three-dimensional images from PET/CT data or synthetic CT maps, with user-drawn lesions user-set acquisition reconstruction parameters. used reproduce the NEMA body phantom...
The aim of this paper is to define the requirements and describe design implementation a standard benchmark tool for evaluation validation PET-auto-segmentation (PET-AS) algorithms. This work follows recommendations Task Group 211 (TG211) appointed by American Association Physicists in Medicine (AAPM).The published AAPM TG211 report were used derive set required features guide structure benchmarking software tool. These items included selection appropriate representative data reference...
Accurate quantification in emission tomography is essential for internal radiopharmaceutical therapy dosimetry. Mean activity concentration measurements objects with diameters less than 10 times the full width at half maximum of imaging system's spatial resolution are significantly affected (>10%) by partial-volume effect. This study develops a framework PET and SPECT characterization proposes 2 MIRD recovery coefficient models—a geometric mean approximation (RECOVER-GM) an empirical...
Abstract This paper presents an accelerated preconditioned proximal gradient algorithm (APPGA) for effectively solving a class of positron emission tomography (PET) image reconstruction models with differentiable regularizers. We establish the convergence APPGA generalized Nesterov (GN) momentum scheme, demonstrating its ability to converge minimizer objective function rates o(1/k^{2ω}) and o(1/k^ω) in terms value distance between consecutive iterates, respectively, where ω∈(0, 1] is power...
We seek to identify dosimetric and anatomic indicators of late rectal toxicity in prostate cancer patients treated with intensity modulated radiation therapy (IMRT). Data from 49 sampled 698 for clinically localized at the Memorial Sloan‐Kettering Cancer Center IMRT a dose were analyzed. The end point study was Grade 2 or worse within 30 months treatment. Dosimetric analysis performed on rectum surface three dimensions two‐dimensional maps obtained by flattening using conformal mapping...
Core biopsies obtained using PET/CT guidance contain bound radiotracer and therefore provide information about tracer uptake in situ. Our goal was to develop a method for quantitative autoradiography of biopsy specimens (QABS), use this correlate <sup>18</sup>F-FDG situ with histopathology findings, briefly discuss its potential application. <b>Methods:</b> Twenty-seven patients referred PET/CT-guided <sup>18</sup>F-FDG–avid primary or metastatic lesions different locations consented...
For multicenter clinical studies, characterizing the robustness of image-derived radiomics features is essential. Features calculated on PET images have been shown to be very sensitive image noise. The purpose this work was investigate efficacy a relatively simple harmonization strategy feature and agreement. A purpose-built texture pattern phantom scanned 10 different scanners in 7 institutions with various acquisition reconstruction protocols. An technique based equalizing...
Oncologic PET images provide valuable information that can enable enhanced prognosis of disease. Nonetheless, such is simplified significantly in routine clinical assessment to meet workflow constraints. Examples typical FDG metrics include: (i) SUVmax, (2) total lesion glycolysis (TLG), and (3) metabolic tumor volume (MTV). We have derived implemented a novel metric for quantification, inspired essence by model generalized equivalent uniform dose as used radiation therapy. The proposed...