A5049595794- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Blood Pressure and Hypertension Studies
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Sleep and related disorders
- Sleep and Wakefulness Research
- Medical Imaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Nutritional Studies and Diet
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Genetics and Neurodevelopmental Disorders
- Spinal Dysraphism and Malformations
- Diet and metabolism studies
- Retinoids in leukemia and cellular processes
- Cardiac Arrest and Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
Cornell University
2021-2025
MIND Research Institute
2022-2024
Weill Cornell Medicine
2021-2024
New York University
2016-2019
NYU Langone Health
2016
Emerging evidence suggests a role for sleep in contributing to the progression of Alzheimer disease (AD). Slow wave (SWS) is stage during which synaptic activity minimal and clearance neuronal metabolites high, making it an ideal state regulate levels amyloid beta (Aβ). We thus aimed examine relationships between concentrations Aβ42 cerebrospinal fluid (CSF) measures SWS cognitively normal elderly subjects.Thirty-six subjects underwent clinical cognitive assessment, structural MRI, morning...
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship not well established in living humans. CSF major feature glymphatic clearance (BGC), has been shown abnormal AD murine models. MRI phase contrast and intrathecally delivered studies have reported reduced flow AD. Using PET tau tracer 18 F-THK5117, we previously that the ventricular was associated with elevated levels....
Abstract INTRODUCTION Mapping of microscopic changes in the perivascular space (PVS) cerebral cortex, beyond magnetic resonance‐visible PVS white matter, may enhance our ability to diagnose Alzheimer's disease (AD) early. METHODS We used cerebrospinal fluid (CSF) water fraction (CSFF), a resonance imaging–based biomarker, characterize brain parenchymal CSF water, reflecting parenchyma. measured CSFF and amyloid beta (Aβ) using 11 C Pittsburgh compound B positron emission tomography...
Summary In animal models, inflammation is both a cause and consequence of seizures. Less known about the role in human epilepsy. We performed positron emission tomography ( PET ) using radiotracer sensitive to brain patient with frontal epilepsy ~36 h after seizure as well during seizure‐free period. When statistically compared group 12 matched controls, patient's scans identified (supplementary motor area) region increased corresponding his clinically defined focus, but postseizure scan...
To evaluate the role of orexin-A with respect to cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers, and explore its relationship cognition sleep characteristics in a group cognitively normal elderly individuals.Subjects were recruited from multiple community sources for National Institutes Health supported studies on aging, CSF biomarkers. Sixty-three participants underwent home monitoring sleep-disordered breathing, clinical, cognitive evaluations, as well lumbar puncture obtain...
Although there is an increasing agreement that hypertension associated with cerebrovascular compromise, relationships between blood pressure (BP) and cerebral flow are not fully understood. It known what BP level, consequently therapeutic goal, optimal for brain perfusion. Moreover, limited data on how affects hippocampal perfusion, a structure critically involved in memory. We conducted cross-sectional (n=445) longitudinal (n=185) study of adults elderly without dementia or clinically...
Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed clearance implicated in Alzheimer’s disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index healthy subjects. also first time effect head size. In accord with prior studies, we show reduced aging, men compared women. However, size may be major...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Accurate identification of cerebral beta-amyloid (Aβ) accumulation is crucial for diagnosing Alzheimer's disease (AD) and determining eligibility anti-Aβ therapies. The Centiloid (CL) scale has emerged as a standardized method to harmonize Aβ positron emission tomography (PET) quantification across different tracers sites. We aimed evaluate the concordance between CL visual interpretation in cohort cognitively impaired (CI) unimpaired (CU)...
We examined whether hypertension (HTN) was associated with Alzheimer's disease-related biomarkers in cerebrospinal fluid (CSF) and how changes blood pressure (BP) related to CSF over time.
The choroid plexus (CP) within the brain ventricles is well-known to produce cerebrospinal fluid (CSF). Recently, CP has been recognized as critical in modulating inflammation. MRI-measured enlargement reported neuroinflammatory disorders like MS well with aging and neurodegeneration. basis of unknown. On tissue studies demonstrating calcification a common pathology associated disease, we hypothesized that previously unmeasured contributes volume may be more specifically neuroinflammation.
Abstract In rodents, hypothalamic inflammation plays a critical role in aging and age-related diseases. Hypothalamic has not previously been assessed vivo humans. We used Positron Emission Tomography (PET) with radiotracer sensitive to the translocator protein (TSPO) expressed by activated microglia, assess correlations between age regional brain TSPO group of healthy subjects (n = 43, 19 female, aged 23–78), focusing on hypothalamus. found robust age-correlated expression thalamus but...
Abstract Background Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging data it remains unknown whether the nasal mucosa is CSF drainage site humans. Here, we used dynamic PET with [1- 11 C]-Butanol, highly permeable radiotracer no appreciable brain binding, to test hypothesis that tracer from pathway reflects brain. As hypothesis, examined...
Repeated mild Traumatic Brain Injury (TBI) is a risk factor for Chronic Encephalopathy (CTE), characterized pathologically by neurofibrillary tau deposition in the depths of brain sulci and surrounding blood vessels. The mechanism which TBI leads to CTE remains unknown but has been posited relate axonal shear injury leading release possibly at time injury. As part an IRB-approved study designed learn how processes occurring acutely after may predict later proteinopathy neurodegeneration, we...
Low-intensity transcranial ultrasound stimulation (TUS) is a non-invasive neuromodulation technique with high spatial resolution and feasible penetration depth. To date, the mechanisms of TUS modulated neural oscillations are not fully understood. This study designed very low acoustic intensity (AI) system that produces considerably reduced AI Ultrasound pulses (ISPTA < 0.5 W/cm2) when compared to previous methods used measure regional oscillation patterns under different parameters.We...
Background: Alzheimer’s disease (AD) pathology is considered to begin in the brainstem, and cerebral microglia are known play a critical role AD pathogenesis, yet little about brainstem AD. Translocator protein (TSPO) PET, sensitive activated microglia, shows high signal dorsal humans, but precise location clinical correlates of this unknown. Objective: To define age associations TSPO PET humans. Methods: We applied new probabilistic maps nuclei quantify PET-measured expression over whole...
Abstract In rodents, hypothalamic inflammation plays a critical role in aging and age-related diseases. We used Positron Emission Tomography with radiotracer sensitive to the TSPO molecule expressed by activated microglia assess, for first time, human inflammation. found that women but not men showed age-correlated expression, suggest this is relevant understanding stark sex difference aging, namely, only undergo menopause.
Background and objectives Obesity is a risk factor for cognitive decline. Probable mechanisms involve inflammation cerebrovascular dysfunction, leading to diminished cerebral blood flow (CBF) reactivity (CVR). The hippocampus, crucially involved in memory processing thus relevant many types of dementia, poses challenge studies perfusion CVR, due its location, small size, complex shape. We examined the relationships between body mass index (BMI) hippocampal resting CBF CVR carbon dioxide (CVR...
Background: There is a well documented relationship between cardiovascular risk factors and the development of brain injury, which can lead to cognitive dysfunction. Hypertension (HTN) condition increasing silent symptomatic ischemic lesions. Although benefits hypertension treatment are indisputable, target blood pressure value where possibility tissue damage most reduced remains under debate. Method: Our group performed cross-sectional ( n = 376) longitudinal 188) study individuals without...