A5033573097- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Protein Structure and Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyomavirus and related diseases
- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cerebrospinal fluid and hydrocephalus
- Silicon and Solar Cell Technologies
- Neuropeptides and Animal Physiology
- Peripheral Neuropathies and Disorders
- Silicon Nanostructures and Photoluminescence
- TiO2 Photocatalysis and Solar Cells
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Histone Deacetylase Inhibitors Research
- Pharmacological Receptor Mechanisms and Effects
- Nicotinic Acetylcholine Receptors Study
- Advanced Photocatalysis Techniques
Howard University
2019-2025
National Institutes of Health
2019-2025
National Institute on Alcohol Abuse and Alcoholism
2021-2025
Cornell University
2015-2021
Weill Cornell Medicine
2016-2021
Xiangyang Central Hospital
2020
Imaging Center
2016
Citigroup
2016
Brookhaven National Laboratory
2013-2014
Stony Brook University
2006-2013
Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies determined that chronic lesions are primarily related the later stages sclerosis; however, occurrence these their relationship earlier disease may be greatly underestimated. Detection across patient spectrum requires validated imaging tool accurately identify with persistent inflammation....
Summary In animal models, inflammation is both a cause and consequence of seizures. Less known about the role in human epilepsy. We performed positron emission tomography ( PET ) using radiotracer sensitive to brain patient with frontal epilepsy ~36 h after seizure as well during seizure‐free period. When statistically compared group 12 matched controls, patient's scans identified (supplementary motor area) region increased corresponding his clinically defined focus, but postseizure scan...
Background: There is a need for reliable and robust Parkinson's disease biomarkers that reflect severity are sensitive to modifying investigational therapeutics.Objective: To demonstrate the utility of EEG as reliable, quantitative biomarker with potential pharmacodynamic endpoint use in clinical assessments neuroprotective therapeutics Parkison's disease.Methods: A multi modal study was performed including aquisition resting state data dopamine transporter PET imaging from patients off...
Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition HDAC potency and selectivity observed, poor penetrance may account for the high doses needed achieve therapeutic efficacy. Here we report development evaluation of highly potent permeable inhibitors CNS applications based on an image-guided approach involving parallel synthesis radiolabeling a series...
Abstract Objective To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation PRL-disrupted WM associated with disability people multiple sclerosis (MS). Methods Forty-four MS patients 16 healthy controls were included. 18 kDa-translocator protein positron emission tomography (TSPO-PET) 11 C-PK11195 radioligand was used to measure neuroinflammatory activity. The Network Modification Tool identify PRLs...
The reliance of quantitative PET imaging on the arterial input function makes brain challenging to perform in certain populations, limiting sample size. To address this challenge, a supervised clustering algorithm (SVCA) has been introduced as an alternative. Our objective was validate SVCA's performance for with [11C]DPA-713 that targets putative marker injury and repair. Methods: This study included composite dataset comprising 12 healthy volunteers (HVs), 6 participants from Weill Cornell...
Traumatic brain injury is a major cause of long term cognitive impairment, yet the mechanisms underlying recovery remain poorly understood. Neuroimaging methods such as diffusion MRI, functional and positron emission tomography (PET) provide insight into micro macro scale changes post TBI, but relationships between regional cellular alterations unclear. In this study, we conducted longitudinal, multimodal neuroimaging analysis quantifying TBI-related pathologies in four biomarkers, namely...
Abstract The continuous rise in opioid overdoses the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse conventional there may be a need for higher or repeated doses of NLX revert from highly fentanyls. Here, we used positron emission tomography (PET) assess NLX’s dose-dependence on both rate displacement [ 11 C]carfentanil ([ C]CFN) binding duration mu receptor...
ABSTRACT BACKGROUND AND PURPOSE Neuroinflammation has been implicated in the pathophysiology of Parkinson's disease (PD), which might be influenced by successful neuroprotective drugs. The uptake [ 11 C](R)‐PK11195 (PK) is often considered to a proxy for neuroinflammation, and can quantified using Logan graphical method with an image‐derived blood input function, or reference tissue model automated region extraction. purposes this study were (1) assess whether these noninvasive image...
Dopamine and glutamate reciprocally regulate each other in some of the neurocircuits affected by Parkinson's disease (PD). The objective this pilot study was to explore relationships between these neurotransmitter systems with positron emission tomography.The sample consisted nine patients PD eight healthy volunteers (HVs). Dynamic images brain were acquired after IV administration ∼370 MBq (10 mCi) [11 C]PE2i, a dopamine transporter (DaT) imaging agent, ∼185 (∼5 [18 F]FPEB, selective...
Dopamine D3 receptor (D3R) antagonists may be effective medications for multiple substance use disorders (SUDs). However, no selective D3R are currently available clinical testing. Buspirone, originally characterized as a 5-HT1A partial agonist and used an anxiolytic, also binds to D4R with high affinity, lower affinity D2R, interferes cocaine reward. Here we PET [11C]PHNO (D3R-preferring radioligand), [11C]raclopride (D2R/D3R radioligand) [11C]NNC-112 (D1R measure occupancy of oral...
Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism which metabolic products, toxins, and other wastes are removed from brain. may be especially important after traumatic brain injury (TBI), when blood, neuronal debris, inflammatory cells, substances can released and/or deposited. Using non-invasive dynamic positron emission tomography (PET) method that models rate at an intravenously injected radiolabeled...
Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake higher MS compared HC within normal‐appearing white matter (NAWM) and gray regions. In patients, increased NAWM ( p = 0.01), cortex 0.04), thalamus putamen 0.02) at 12 months. Among remaining 24 months, there no further increase...
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Chronic active multiple sclerosis (MS) lesions have a rim of activated microglia/macrophages (m/M) leading to ongoing tissue damage, and thus represent potential treatment target. Activation this innate immune response in MS has been visualized quantified using PET imaging with [11C]-(R)-PK11195 (PK). Accurate identification m/M activation chronic requires the sensitivity detect lower levels activity within small volume. We assessed ability kinetic modeling PK data different central nervous...
Arachidonic acid (AA) is involved in signal transduction, neuroinflammation, and production of eicosanoid metabolites. The AA brain incorporation coefficient (K*) quantifiable vivo using [11 C]AA positron emission tomography, although repeatability remains undetermined. We evaluated K* estimates obtained with population-based metabolite correction (PBMC) image-derived input function (IDIF) comparison to arterial blood-based estimates, compared repeatability. Eleven healthy volunteers...
Abstract Abdominal aortic aneurysm (AAA) is a degenerative vascular disease impacting aging populations with high mortality upon rupture. There are no effective medical therapies to prevent AAA expansion and We previously demonstrated the role of monocyte chemoattractant protein-1 (MCP-1) / C-C chemokine receptor type 2 (CCR2) axis in rodent pathogenesis via positron emission tomography/computed tomography (PET/CT) using CCR2 targeted radiotracer 64 Cu-DOTA-ECL1i. have since translated this...
Raman-based spectral modification for improved solar cell (SC) performance was investigated. While, Raman scattering is a weak phenomena commonly used material characterization, small-sized particles embedded in light matrix have increased and anti-Stokes energy up shift probability; because, embedding diffusive, transparent vastly increases path lengths (kilometers) because optically generated phonons contribute to probability long phonon lifetime small particles. Increased wavelength...
The olive baboon ( Papio anubis ) is phylogenetically proximal to humans. Investigation into the brain has shed light on function and organization of human brain, as well mechanistic insights neurological disorders such Alzheimer’s Parkinson’s. Non-invasive imaging, including positron emission tomography (PET) magnetic resonance imaging (MRI), are primary outcome measures frequently used in studies. PET functional long been study cerebral metabolic processes, though it lacks clear reliable...
Einstein relations define ratios for diffusion and drift currents an ensemble of particles moving via probabilistic events such as hops. An relation was derived charged constrained to move integral part a system having energy consideration routed in its material matrix. For example, the cases where deformation matrix or lattice structure stores releases free upon electron concentration change. Using analysis based on gradients, diffusion, steady state, thermodynamic framework energy-coupled...