A5052382324- Estrogen and related hormone effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Cancer and Skin Lesions
- Male Breast Health Studies
- Computational Drug Discovery Methods
- Effects and risks of endocrine disrupting chemicals
- Receptor Mechanisms and Signaling
- Breast Lesions and Carcinomas
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Opioid Use Disorder Treatment
- Neurotransmitter Receptor Influence on Behavior
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Veterinary Pharmacology and Anesthesia
- Bipolar Disorder and Treatment
- Hormonal Regulation and Hypertension
National Institutes of Health
2017-2024
National Institute on Alcohol Abuse and Alcoholism
2018-2024
U.S. Army Research Institute of Environmental Medicine
2021
United States Army
2021
National Institute of Environmental Health Sciences
2017-2020
Campbell University
2019-2020
Previous case reports associated prepubertal gynecomastia with lavender-containing fragrances, but there appear to be no of premature thelarche.To add a series about lavender-fragranced product use and breast growth in children measure endocrine-disrupting chemical activity essential oil components.Patients experiencing thelarche or continuous exposure products were evaluated the pediatric endocrinology departments two institutions. Mechanistic vitro experiments using eight components...
Background: Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that might be harmful to human health. Recently, there has been widespread usage of bisphenol chemicals (BPs), such as AF (BPAF) and S (BPS), replacements for BPA. However, the potential biological actions, toxicity, molecular mechanism these compounds are still poorly understood. Objectives: Our objective was examine estrogenic effects BPA, BPAF, BPS mechanisms action in estrogen receptor alpha (ERα) complex. Methods:...
Abstract The continuous rise in opioid overdoses the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse conventional there may be a need for higher or repeated doses of NLX revert from highly fentanyls. Here, we used positron emission tomography (PET) assess NLX’s dose-dependence on both rate displacement [ 11 C]carfentanil ([ C]CFN) binding duration mu receptor...
Significance Early developmental exposure to endocrine active compounds causes late-stage effects and alterations in the reproductive tract of adult mice. Unexpectedly, estrogen receptor alpha (ERα) plays a pivotal role mediating these effects. As model outcome from effects, we present transcriptome DNA methylation profiling seminal vesicles (SVs) following neonatal diethylstilbestrol (DES) exposure. ERα mediates aberrations SVs mice that impact reprogramming at adulthood. dynamically...
Central adenosine A1 receptor (A1R) is implicated in pain, sleep, substance use disorders, and neurodegenerative diseases, an important target for pharmaceutical development. Radiotracers A1R positron emission tomography (PET) would enable measurement of the dynamic interaction endogenous during sleep–awake cycle. Although several human PET tracers have been developed, most are xanthine-based antagonists that failed to demonstrate competitive binding against adenosine. Herein, we explored...
Abstract Estrogen (E2) signaling through its nuclear receptor, E2 receptor α (ERα) increases insulinlike growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via IGF1 receptor. Directly administering results similar biological and transcriptional uterine responses. Our studies using global ERα-null mice demonstrated a loss of responses uterus to or treatment, while maintaining IGF1. To address this discrepancy need for ERα mediating vs responses, we assessed...
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Abstract Introduction Post‐traumatic stress disorder (PTSD) is an anxiety induced by psychologically traumatic events. Using a rat model, this study aimed to determine whether psychological trauma alters relative expression between pro‐inflammatory and anti‐inflammatory markers in microglia. To meet goal, of genes encoding i‐NOS, arginase, TNF‐α, interleukin‐10, CD74, Mannose Receptor C was analyzed on multiple days following exposure. Methods Single‐prolonged (SPS) used model PTSD male...
A patient-derived mutation in ERα that causes estrogen insensitivity alters coregulator recruitment.
Abstract The continuous rise in opioid overdoses the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse conventional there may be a need for higher or repeated doses of NLX revert from highly fentanyls. Here, we used positron emission tomography (PET) assess NLX’s dose-dependence on both rate displacement [ 11 C]carfentanil ([ C]CFN) binding duration mu receptor...