A5071072111- Spinal Fractures and Fixation Techniques
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Sleep and related disorders
- Atrial Fibrillation Management and Outcomes
- Inflammatory Bowel Disease
- Neuroscience and Neuropharmacology Research
- Spine and Intervertebral Disc Pathology
- Diptera species taxonomy and behavior
- Bacterial biofilms and quorum sensing
- Pelvic and Acetabular Injuries
- Youth Substance Use and School Attendance
- Advanced NMR Techniques and Applications
- Orthopedic Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- Insect behavior and control techniques
- Helminth infection and control
- Bacteriophages and microbial interactions
- Acoustic Wave Phenomena Research
- Dental Radiography and Imaging
- Reproductive tract infections research
- Diagnosis and treatment of tuberculosis
- Elbow and Forearm Trauma Treatment
- Atomic and Subatomic Physics Research
- Pancreatic function and diabetes
National Institute of Mental Health
2014-2024
National Institutes of Health
2009-2024
Baylor Scott & White Medical Center - Temple
2022-2024
Public Health Wales
2023-2024
University of Chicago
1998-2023
Boehringer Ingelheim (United States)
2022-2023
Emory University
2013-2022
Cedars-Sinai Medical Center
2022
Medical College of Wisconsin
2022
Johns Hopkins University
2022
Significance Orthopedic implant infections require long-term antibiotic therapy and surgical debridement to successfully retain the implant; however, therapeutic failure can lead removal. Here an injectable PEG-based hydrogel that adheres exposed tissue fracture surfaces is engineered deliver antimicrobial enzyme lysostaphin infected, implant-fixed, mouse femoral fractures. Lysostaphin encapsulation within enhances stability while providing enhanced antibiofilm activity serving as a...
Abstract Stem cell therapies are limited by poor survival and engraftment. A hurdle to the use of materials for delivery is lack understanding material properties that govern transplanted stem functionality. Here, we show synthetic hydrogels presenting integrin-specific peptides enhance survival, persistence, osteo-reparative functions human bone marrow-derived mesenchymal cells (hMSCs) in murine defects. Integrin-specific regulate hMSC adhesion, paracrine signaling, osteoblastic...
Psychological treatment of insomnia has focused on primary (i.e., having a psychological origin). Secondary insomnia, sleep disturbance caused by psychiatric or medical disorder, although it is more common than received very little attention as result the belief that would be refractory to treatment. The present study randomly assigned older adults with secondary group, 4 sessions composed relaxation and stimulus control, no-treatment control group. Self-report assessments conducted at...
Islet transplantation is a promising alternative therapy for insulin-dependent patients, with the potential to eliminate life-threatening hypoglycemic episodes and secondary complications of long-term diabetes. However, widespread application this has been limited by inadequate graft function longevity, in part due loss up 60% hostile intrahepatic transplant site. We report proteolytically degradable synthetic hydrogel, functionalized vasculogenic factors localized delivery, engineered...
Epithelial cells cultured within collagen and laminin gels proliferate to form hollow polarized spherical structures, recapitulating the formation of a rudimentary epithelial organ. However, contributions extracellular matrix (ECM) biochemical biophysical properties morphogenesis are poorly understood because uncontrolled presentation multiple adhesive ligands, limited control over mechanical properties, lot-to-lot compositional variability in these natural ECMs. We engineered synthetic...
Bacterial adhesion to stainless steel 316L (SS316L), which is an alloy typically used in many medical devices and food processing equipment, can cause serious infections along with substantial healthcare costs. This work demonstrates that nanotextured SS316L surfaces produced by electrochemical etching effectively inhibit bacterial of both Gram-negative Escherichia coli Gram-positive Staphylococcus aureus, but exhibit cytocompatibility no toxicity toward mammalian cells vitro. Additionally,...
Use of BMP-2 and lysostaphin-loaded hydrogels simultaneously clears S. aureus infection repairs bone defects.
Abstract Implanted orthopedic devices become infected more frequently than any other implanted surgical device. These infections can be extremely costly and result in significant patient morbidity. Current treatment options typically involve the long term, systemic administration of a combination antibiotics, often followed by implant removal. Here we engineered an injectable hydrogel capable encapsulating Pseudomonas aeruginosa bacteriophage delivering active phage to site bone infections....
Data from experimental models of atrial flutter indicate that macro-reentrant circuits may be confined by anatomic and functional barriers remote the tricuspid annulus-eustachian ridge isthmus. characterizing various forms atypical in humans are limited.In 6 160 consecutive patients referred for ablation counterclockwise and/or clockwise typical flutter, an additional was mapped to right free wall. Five had no prior cardiac surgery. Incisional tachycardia excluded remaining patient....
Probe tests provide an important additional converging operation to identify the characteristics of cognitive processes being assessed by other behavioral measures. We introduce a new procedure using variable-interval (VI) probe test assess spatial memory in water maze. Three groups rats were trained discrimination with traditional platform trials. For trials, 2 had no-platform (NP) trials which escape was unavailable for entire trial. The 3rd group variable interval available only after VI....
Purpose To achieve detection of glutamate (Glu), glutamine (Gln), and glutathione (GSH) by minimizing the N‐acetyl‐aspartate (NAA) multiplet signals at 2.49 ppm using a echo time (TE) ‐optimized PRESS pulse sequence novel J‐suppression radiofrequency pulse. Methods Using density matrix simulations, with (TE 1 , TE 2 ) = (69, 37) ms an inserted 90° were found to minimize NAA ppm. Results phantom experiments confirmed successful suppression A study eight healthy volunteers both Glu Gln be...
The black soldier fly is a non-pest insect of interest to the sustainability community due high eating rates its edible larvae. When found on carcases or piles rotting fruit, this larva often outcompetes other species scavengers for food. In combined experimental and theoretical study, we elucidate mechanism by which groups larvae can eat so quickly. We use time-lapse videography particle image velocimetry investigate feeding Individually, in 5 min bursts, 44% time, they are near This...
Cell therapy is an emerging paradigm for the treatment of heart disease. In spite exciting and promising preclinical results, benefits cell cardiac repair in patients have been modest at best. Biomaterials-based approaches may overcome barriers poor differentiation retention transplanted cells. this study, we prepared tested hydrogels presenting extracellular matrix (ECM)-derived adhesion peptides as delivery vehicles c-kit+ progenitor cells (CPCs). We assessed their effects on behavior...
Abstract This study presents the detection of [2‐ 13 C]glucose metabolism in carboxylic/amide region human brain, and demonstrates that cerebral can be studied subjects presence severe hardware constraints widely available 3 T clinical scanners with low‐power stochastic decoupling. In primary products C label incorporation from into glutamate, glutamine, aspartate, γ‐aminobutyric acid, N‐acetylaspartate were detected. Unlike commonly used alkanyl where lipid signals spread over a broad...