A5044339369- biodegradable polymer synthesis and properties
- Antimicrobial agents and applications
- Mesenchymal stem cell research
- Polymer Surface Interaction Studies
- X-ray Diffraction in Crystallography
- Carbon dioxide utilization in catalysis
- Crystallization and Solubility Studies
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Bacteriophages and microbial interactions
- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- Bacterial Genetics and Biotechnology
- Chemical Synthesis and Reactions
- Orthopedic Infections and Treatments
- Xenotransplantation and immune response
- Click Chemistry and Applications
- Probiotics and Fermented Foods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Peptides and Activities
Georgia Institute of Technology
2016-2024
AID Atlanta
2018
Use of BMP-2 and lysostaphin-loaded hydrogels simultaneously clears S. aureus infection repairs bone defects.
Abstract For cell therapies, the subcutaneous space is an attractive transplant site due to its large surface area and accessibility for implantation, monitoring, biopsy, retrieval. However, poor vascularization has catalyzed research induce blood vessel formation within enhance revascularization survival. Most studies focus on of rodents, which does not recapitulate important anatomical features responses humans. Herein, we evaluate biomaterial‐driven in porcine space. Additionally, report...
Hydrogel microparticles (microgels) are an attractive approach for therapeutic delivery because of their modularity, injectability, and enhanced integration with the host tissue. Multiple microgel fabrication strategies chemistries have been implemented, yet manipulation degradability its effect on in vivo tissue responses remains underexplored. Here, authors report a facile method to synthesize microgels crosslinked ester-containing junctions afford tunable degradation kinetics....
The ring-opening copolymerization of 3,6-bis(chloromethyl)-1,4-dioxane-2,5-dione and l-lactide affords a chloro-substituted polylactide copolymer (chloro-PL). Base-promoted dehydrochlorination chloro-PL provides (ene-PL) that contains electrophilic α,β-unsaturated ester units. undergoes conjugate addition with variety thiols in solution under mildly basic conditions also the presence AIBN. Reaction on surface films unsaturated copolyester is demonstrated by thiol-substituted fluorescent dye.
Polylactide (PL) co-polymers substituted with pendant azide groups (azido-PL) were synthesized by the nucleophilic conjugate addition of 3-azido-1-propanethiol to a co-polymer PL containing α,β-unsaturated ester units, poly(lactide-co-methylene glycolide) (ene-PL) that is obtained from base-promoted dehydrochlorination poly(lactide-co-chlorolactide) (chloro-PL). Alternatively, azido-PL was prepared treatment chloro-PL without isolation ene-PL intermediate. The functionalized copper-catalyzed...
Tricomponent amphiphilic brush-grafted copolymers of poly(lactic acid)-graft-poly(oligo(ethylene glycol) methacrylate) (PLA-g-POEGMA) were prepared by atom-transfer radical polymerization (ATRP) oligo(ethylene methacrylate (OEGMA) macromer using brominated acid) (Br-PLA) as a multisite macroinitiator. Br-PLA was free bromination (PLA) with N-bromosuccinimide (NBS). The copolymer, PLA-g-POEGMA, self-assembled to form sub-100 nm nanoparticles in aqueous solution. We report the uptake and...
Abstract Lung infections caused by Gram‐positive Staphylococcus aureus ( S. ) and coinfections Gram‐negative Pseudomonas aeruginosa P. are challenging to treat, especially with the rise in number of antibiotic‐resistant strains these pathogens. Bacteriophage (phage) bacteria‐specific viruses that can infect lyse bacteria, providing a potentially effective therapy for bacterial infections. However, development bacteriophage is impeded limited suitable biomaterials facilitate delivery phage...
Abstract Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. barriers consist of perineurial, endothelial myelin barriers. So far, it is unclear whether resealing fosters resolution recovery. To this end, we analysed the property portfolio, behaviour battery lipidomics for precursors specialized pro-resolving meditators (SPMs) their receptors in chronic constriction rat sciatic to identify targets by selected Of three barriers—perineurium, capillaries myelin—only...
A copolylactide that is substituted with pendent thiol groups (thiol-PL) undergoes coupling a variety of electrophiles under mild conditions <italic>via</italic> thiol–ene addition.
Abstract Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. barriers consist of perineurial, endothelial, myelin barriers. So far, it is unclear whether resealing fosters resolution recovery. To this end, we analysed the property portfolio, behaviour battery, lipidomics for precursors specialized pro-resolving meditators (SPMs) their receptors in chronic constriction rat sciatic to identify targets by selected Of three – perineurium, capillaries, only capillary...