A5050956894- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Atomic and Subatomic Physics Research
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Medical Imaging Techniques and Applications
- Sleep and related disorders
- Eating Disorders and Behaviors
- Regulation of Appetite and Obesity
- Attention Deficit Hyperactivity Disorder
- Receptor Mechanisms and Signaling
- Mental Health Research Topics
- Nuclear Physics and Applications
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Radiation Detection and Scintillator Technologies
- Advanced NMR Techniques and Applications
- Cannabis and Cannabinoid Research
National Institute on Alcohol Abuse and Alcoholism
2016-2025
National Institutes of Health
2016-2025
Yokohama City University
2024
National Institute on Drug Abuse
2011-2017
Cognitive Neuroimaging Lab
2017
Brookhaven National Laboratory
2006-2016
Universidad Autónoma Metropolitana
2008-2012
Brookhaven College
2009-2011
Icahn School of Medicine at Mount Sinai
2011
Stony Brook University
2011
Significance There has been an emerging interest in sleep and its association with β-amyloid burden as a risk factor for Alzheimer’s disease. Despite the evidence that acute deprivation elevates levels mouse interstitial fluid human cerebrospinal fluid, not much is known about impact of on brain. Using positron emission tomography, here we show impacts brain regions have implicated Our observations provide preliminary negative effect
Brain networks with energy-efficient hubs might support the high cognitive performance of humans and a better understanding their organization is likely relevance for studying not only brain development plasticity but also neuropsychiatric disorders. However, distribution in human largely unknown due to computational demands comprehensive analytical methods. Here we propose 10 3 times faster method map local functional connectivity density (lFCD) brain. The robustness this was tested 979...
The brain's functional connectivity is complex, has high energetic cost, and requires efficient use of glucose, the main energy source. It been proposed that regions with a degree are can minimize consumption glucose. However, relationship between in brain poorly understood. To address this neglect, here we propose simple model for demands connectivity, which tested positron emission tomography MRI 54 healthy volunteers at rest. Higher glucose metabolism was associated proportionally larger...
Functional networks are usually accessed with "resting-state" functional magnetic resonance imaging using preselected "seeds" regions. Frequently, however, the selection of seed locations is arbitrary. Recently, we proposed local connectivity density mapping (FCDM), an ultrafast data-driven to locate highly connected brain regions (functional hubs). Here, used hubs obtained from FCDM determine resting state in 979 healthy subjects without a priori hypotheses on locations. In addition,...
Abstract The neural bases of gender differences in emotional, cognitive, and socials behaviors are largely unknown. Here, magnetic resonance imaging data from 336 women 225 men revealed a dimorphism the functional organization brain. Consistently across five research sites, had 14% higher local connectivity density ( l FCD) up to 5% gray matter than cortical subcortical regions. negative power scaling FCD was steeper for women, suggesting that balance between strongly weakly connected nodes...
The significant weight loss observed with combination naltrexone-sustained release (SR) 32 mg and bupropion SR 360 (NB32) therapy is thought to be due, in part, stimulation of hypothalamic pro-opiomelanocortin (POMC) neurons, naltrexone blockade opioid receptor-mediated POMC autoinhibition, but the neurobiological mechanisms are not fully understood. We assessed changes brain reactivity food cues before after NB32 treatment. Forty women (31.1±8.1 years; body mass index: 32.5±3.9) received 4...
Dopamine D2 receptors are involved with wakefulness, but their role in the decreased alertness associated sleep deprivation is unclear. We had shown that reduced dopamine D2/D3 receptor availability (measured PET and [ 11 C]raclopride controls) striatum, could not determine whether this reflected increases ([ competes for binding) or downregulation. To clarify this, we compared induced by methylphenidate (a drug blocking transporters) during versus rested sleep, assumption methylphenidate's...
Stimulant medications, such as methylphenidate, which are effective treatments for attention deficit hyperactivity disorder (ADHD), enhance brain dopamine signaling. However, the relationship between regional enhancement and treatment response has not been evaluated. Here, we assessed whether increases elicited by methylphenidate associated with long-term clinical response. We used a prospective design to study 20 treatment-naive adults ADHD who were evaluated before initiation after 12...
Significance Marijuana abusers show lower positive and higher negative emotionality scores than controls, which is consistent, on one hand, with reward sensitivity motivation and, the other increased stress reactivity irritability. To investigate this aspect of marijuana’s impact human brain, we compared brain’s in marijuana vs. controls when challenged methylphenidate (MP). We found that display attenuated dopamine (DA) responses to MP, including reduced decreases striatal distribution...
Neuroimaging studies have identified functional interactions between the thalamus, precuneus, and default mode network (DMN) in of consciousness.However, less is known about structural connectivity precuneus thalamus to regions within DMN.We used diffusion tensor imaging (DTI) parcellate based on their probabilistic white matter each other DMN interest (ROIs) 37 healthy subjects from Human Connectome Database.We further assessed resting-state (RSFC) among ROIs.The was found greatest with...
The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in MAO gene (MAOA, Mendelian Inheritance Men database number 309850, referred to as high or low based on transcription non-neuronal cells) has been investigated externalizing behavioral clinical phenotypes. These studies provide evidence linking MAOA genotype violent...