A5055170056- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Eating Disorders and Behaviors
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Sleep and related disorders
- Advanced MRI Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Prenatal Substance Exposure Effects
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Neurological disorders and treatments
- Treatment of Major Depression
- Obesity, Physical Activity, Diet
- Alcoholism and Thiamine Deficiency
- Parkinson's Disease Mechanisms and Treatments
National Institute on Alcohol Abuse and Alcoholism
2017-2025
National Institutes of Health
2017-2025
University of Maryland, Baltimore
2025
Stony Brook University
2014-2018
Yale University
2010-2016
State University of New York
2016
Significance There has been an emerging interest in sleep and its association with β-amyloid burden as a risk factor for Alzheimer’s disease. Despite the evidence that acute deprivation elevates levels mouse interstitial fluid human cerebrospinal fluid, not much is known about impact of on brain. Using positron emission tomography, here we show impacts brain regions have implicated Our observations provide preliminary negative effect
Low socioeconomic status (SES) in childhood is associated with deficits executive function and changes cortical morphology. Furthermore, rates of obesity are greater among low SES children also alterations impaired neurocognition, specifically the domain function. To investigate influence BMI on relationships between both neurocognition brain morphology, we used data from Adolescent Brain Cognitive Development (ABCD) study to construct multiple linear regression models conduct mediation...
Importance Cannabis use has increased globally, but its effects on brain function are not fully known, highlighting the need to better determine recent and long-term activation outcomes of cannabis use. Objective To examine association lifetime history heavy with across a range functions in large sample young adults US. Design, Setting, Participants This cross-sectional study used data (2017 release) from Human Connectome Project (collected between August 2012 2015). Young (aged 22-36 years)...
Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to severity and neurotoxicity AUD ketogenic diet (KD) mitigate these effects. found inpatients randomized receive KD (n = 19) required fewer benzodiazepines first week detoxification, comparison those receiving standard American (SA) 14). Over 3-week treatment, compared SA showed lower "wanting"...
Abstract Parkinson's disease is a neurodegenerative disorder characterized by changes to dopaminergic function in the striatum and range of cognitive motor deficits. Neuroimaging studies have repeatedly shown differences activation functional connectivity patterns between symptomatic individuals with healthy controls. However, presence severity symptoms seem differ dramatically among at early‐stages. To investigate neural basis such heterogeneity, we examined resting state caudate putamen...
Resting-state functional connectivity (rsFC) is widely used to examine cerebral organization. The imaging literature has described lateralization of insula activations during cognitive and affective processing. Evidence appears support a role the right-hemispheric in attentional orientation salient stimulus, interoception, physiological arousal, left-hemispheric control, as well perspective taking. In this study, large data set healthy adults, we examined rsFC anterior (AI) by computing...
Objective The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting‐state networks involved salience, executive control, interoception participants with obesity (OB). Methods Using magnetic resonance imaging independent component analysis FC, 35 OB normal‐weight controls (NW) were investigated. Results Compared NW, showed reduced FC strength the ventromedial prefrontal cortex posterior cingulate cortex/precuneus default‐mode...
Human working memory (WM) is inherently limited, so we must filter out irrelevant information in our environment or mind while retaining limited important relevant contents. Previous work suggests that neural oscillations the alpha band (8-14 Hz) play an role inhibiting incoming distracting during attention and selective encoding tasks. However, whether power involved no-longer-relevant content representing WM still debated. To clarify this issue, manipulated amount of relevant/irrelevant...
Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly early age initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated we hypothesized that regular CA would be altered resting-state functional connectivity midbrain-striatal circuits. We examined brain activity subcortical regions 441 young adults from Human...
Abstract The human brain is organized into segregated networks with strong within-network connections and relatively weaker between-network connections. This “small-world” organization may be essential for maintaining an energetically efficient system, crucial to the which consumes 20% of body’s energy. Brain network segregation glucose energy utilization both change throughout lifespan. However, it remains unclear whether these processes interact contribute differences in cognitive...
Children in the United States sleep less than recommended amount and deficiencies may be worse among disadvantaged children. Prior studies that compared time children of different race/ethnic groups mostly relied on questionnaires or were limited to small sample sizes. Our study takes advantage Adolescent Brain Cognitive Development compare total using a week actigraphy data American (n = 4,207, 9 13 y old) racial/ethnic income groups. We also assessed effects neighborhood deprivation,...
Importance Sleep and circadian disruptions are highly prevalent in opioid use disorder (OUD) a barrier to successful treatment recovery; yet few objective data available, especially for individuals OUD with agonist therapy. If remain present despite treatment, this information would yield potential new targets adjunctive Objective To systematically investigate different aspects of rest-activity rhythms (RAR), including sleep, physical activity, rhythmicity, brain functional correlates OUD....
Abstract Objective The aim of this study was to investigate the relationship between obesity (OB) progression and brain structural changes. Methods T1‐weighted magnetic resonance images were acquired from 258 participants with overweight (OW) or OB 74 normal weight. Participants OW divided into four groups according BMI grades. Two‐sample t tests compared disparities subgroups We used causal covariance networks examine progressive impact on structure. Results With increasing values,...
Methylphenidate (MP) is a widely used stimulant medication for the treatment of attention deficit hyperactivity disorder that enhances brain dopamine signaling and improves attention. However, how stimulation alters state dynamics to support improved during task performance still unclear. To address this, we employed multimodal neuroimaging approach combining positron emission tomography, functional magnetic resonance imaging, behavioral tasks, discover associations between signaling,...
Stimulant drugs that boost dopamine, like methylphenidate (MP), enhance attention and are effective treatments for attention-deficit hyperactivity disorder (ADHD). Yet there is large individual variation in attentional capacity response to MP. It unclear whether this driven by differences relative density of dopamine receptor subtypes, magnitude increases induced MP, or both. Here, we extensively characterized the brain system with positron emission tomography (PET) imaging (including...