A5082665910- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Biology and Fertility
- Vitamin D Research Studies
- Cancer Treatment and Pharmacology
- Ovarian function and disorders
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Diabetes Treatment and Management
- Breast Cancer Treatment Studies
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Estrogen and related hormone effects
- Lipid metabolism and disorders
- Adrenal Hormones and Disorders
- Cholesterol and Lipid Metabolism
- Sperm and Testicular Function
Qingdao University
2025
Chinese Center For Disease Control and Prevention
2022-2024
Harbin Medical University
2022-2024
Shanghai Jiao Tong University
2023-2024
Sun Yat-sen University
2022-2024
Nanjing Agricultural University
2023-2024
First Hospital of Jilin University
2024
Jilin University
2024
Southeast University
2022-2024
Shandong University
2014-2023
Abstract Background Autoimmune diseases (ADs) present significant health challenges globally, especially among adolescents and young adults (AYAs) due to their unique developmental stages. Comprehensive analyses of burden are limited. This study leverages the Global Burden Disease (GBD) 2021 data assess global, regional, national trends major ADs AYAs from 1990 2021. Methods Utilizing Study for individuals aged 15–39 years, we employed a direct method age standardization calculate estimates...
Objective To evaluate the relationship between serum total testosterone (TT) level and lipid profile after adjusting for some traditional confounding factors, free thyroid hormones TSH in Chinese men. Methods This was a retrospective study based on an epidemiological investigation including 11 000 subjects. Bivariate partial correlation analysis, multiple linear regression general model were used to assess influence of TT profile. Additionally, odds ratios (ORs) (95% CIs)...
Objectives . To evaluate the effect of levothyroxine (LT 4 ) replacement therapy on nonalcoholic fatty liver disease (NAFLD) in subclinical hypothyroidism (SCH) patients. Methods This study was a post hoc analysis randomized controlled trial and involved 33 significant 330 mild SCH All patients received LT supplement. The were grouped as treated or not. After 15 months follow-up, prevalence NAFLD each group reevaluated. Subgroup conducted with dyslipidemia. Results treatment , reduced from...
Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule subclinical hypothyroidism (SCH). L-thyroxine replacement therapy (LRT) usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid mild people could also benefit from LRT. However, the benefits were different among individuals, as shown by variations drug dosage required to maintain TSH stability. Alternative pathways, such sulfation glucuronidation...
Objective: To investigate the characteristics of body fat distribution and relationship between index Atherogenic Index Plasma (AIP) in Type 2 Diabetes Mellitus (T2DM) patients. Methods: A total 316 participants were divided into a T2DM group non-diabetes (controls). According to Visceral Fat Area (VFA), all further VFA ≥100 cm2 <100 groups. compare differences blood lipid, glucose, AIP groups, single factor correlation analysis was used determine indexes AIP, multiple linear regression...
Subclinical hypothyroidism is associated with cardiovascular diseases, yet the underlying mechanism remains largely unknown. Herein, in a common population (n = 1,103), TSH level was found to be independently correlated both carotid plaque prevalence and intima-media thickness. Consistently, receptor ablation ApoE-/- mice attenuated atherogenesis, accompanied by decreased vascular inflammation macrophage burden atherosclerotic plaques. These results were also observed myeloid-specific...
Although the association between hypothyroidism and idiopathic pulmonary fibrosis (IPF) is found in observational studies, it remains uncertain whether causally influences IPF.Two-sample Mendelian randomisation (MR) was conducted with genome-wide study (GWAS) data UK Biobank from 289,307 individuals (18,740 cases 270,567 controls) largest GWAS summary statistics of IPF 11,259 (2,668 8,591 controls). Findings were verified using an independent validation dataset, as well through different MR...
Subclinical hypothyroidism (SCH) is an important public health problem worldwide for its increasing prevalence and potential deleterious effects, whereas etiology has not been fully elucidated. Lipotoxicity exerts extensive serious impact on human health, but so far, the effect of lipotoxicity thyroid unclear.The objective study was to assess association between serum triglyceride levels risk SCH.We conducted a population-based case-control study. A total 24 100 subjects with similar stable...
Dyslipidemia is an important global health problem, particularly in the elderly population. Traditionally, high prevalence of dyslipidemia people considered a "natural condition." Notably, subclinical hypothyroidism (SCH) one most risk factors for dyslipidemia. Few studies have assessed whether SCH plays role increase age-related This study aimed to explore association between and lipid profiles different age groups.This was large-scale, population-based, case-control study. The population...
Abstract Aim This study aimed to describe self‐management among cervical cancer patients and elucidate the relationship between illness perception in with cancer. Methods was a cross‐sectional study. A convenience sample of 220 recruited from gynaecology outpatient department hospital. Data were collected September 2018 February 2019. Self‐management assessed using Cancer Self‐Management Assessment Scale Revised Illness Perception Questionnaire for cancer, respectively. analysed Pearson...
Cholesterol synthesis is regulated by the transcription factor sterol regulatory element binding protein 2 (SREBP-2) and its target gene 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), which rate-limiting enzyme in cholesterol synthesis. Cyclic adenosine monophosphate-responsive (CRE) protein-regulated coactivator (CRTC) master regulator of glucose metabolism. However, effect CRTC2 on potential molecular mechanism remain unclear. Here, we demonstrated that expression liver content...
The prevalence of cardiovascular disease has been increasing worldwide. As a common pathogenic risk factor, dyslipidemia played great role in the incidence and progress these diseases. We investigated to achieve accurate up-to-date information on its associations with other lipid-related diseases rural North China. Using complex, multistage, probability sampling design, we conducted large-scale cross-sectional study 8528 participants aged over 18 years Shandong Province. Prevalence...
Observational studies have investigated the associations between antihypertensive drugs and fracture risk as well bone mineral density (BMD), but yielding controversial results.In this study, a comprehensive drug-target Mendelian randomization (MR) analysis was conducted to systematically examine genetic proxies for eight common three health-related traits (fracture, total body BMD [TB-BMD], estimated heel [eBMD]). The main used inverse-variance weighted (IVW) method estimate causal effect....
Subclinical hypothyroidism (SCH) has a high global prevalence. Most SCH patients have mild cases (thyrotropin ≤10 mIU/L). Treatment recommendations for are controversial, which raises concerns about the natural history of SCH. We aimed to clarify This is prospective population-based study. measured thyroid function in 11,000 participants REACTION study and followed 505 newly diagnosed aged 40-years or older between 2011 2014. Logistic regression analysis was used seek baseline parameters...
Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects initiation and progression diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for increased cardiovascular diseases subclinical hypothyroidism (SCH). However, effects underlying mechanisms elevated TSH on are still ambiguous. We sought...