A5100331112- Parathyroid Disorders and Treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Pituitary Gland Disorders and Treatments
- Bone and Dental Protein Studies
- Genetic Syndromes and Imprinting
- Adrenal Hormones and Disorders
- Plant-based Medicinal Research
- Thyroid Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Circadian rhythm and melatonin
- Connective tissue disorders research
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- Crystal Structures and Properties
- Nutrition and Health in Aging
- Hematological disorders and diagnostics
- Magnesium in Health and Disease
- Bone and Joint Diseases
- Dermatological and Skeletal Disorders
- Hip and Femur Fractures
- Nanoparticle-Based Drug Delivery
Peking Union Medical College Hospital
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Division of Undergraduate Education
2024
Shandong University
2017-2023
State Key Laboratory of Crystal Materials
2023
Shenyang Agricultural University
2021
The First Hospital of Kunming
2020
Shandong Provincial Hospital
2017
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It curable by excision of the causative tumor. However, few cases may persist or relapse after tumor resection. We aimed to investigate rate these events and related factors. retrospectively studied TIO patients treated with surgery in tertiary hospital. was established based on pathologic examination reversion hypophosphatemia. Refractory consisted those nonremission recurrent hypophosphatemia surgery. A total 230...
Inorganic Bi-based perovskites have shown great potential in X-ray detection for their large absorption to X-rays, diverse low-dimensional structures, and eco-friendliness without toxic metals. However, they suffer from poor carrier transport properties compared Pb-based perovskites. Here, we propose a mixed-halogen strategy tune the structural dimensions optoelectronic of Cs3 Bi2 I9-n Brn (0≤n≤9). Ten centimeter-sized single crystals are successfully grown by Bridgman technique. Upon doping...
Abstract Context Phosphate homeostasis was compromised in tumor-induced osteomalacia (TIO) due to increased fibroblast growth factor 23 (FGF23) secretion. Nevertheless, the glucose metabolic profile TIO patients has not been investigated. Objectives This work aimed clarify profiles and explore their interaction with impaired phosphate homeostasis. Methods 20 patients, individuals normal tolerance, type 2 diabetes mellitus (DM) were enrolled underwent an oral tolerance test (OGTT). Serum...
Abstract Context Osteopetrosis (OPT) is a rare skeletal disease characterized by high bone mass that has two major inheritance patterns: autosomal dominant osteopetrosis (ADO) and recessive (ARO). However, comprehensive descriptions of microarchitecture in OPT patients are limited. Objectives The aim this study was to comprehensively investigate the patients, explore age-related alterations describe heterogeneity among different genotypes. Methods Nine including 7 ADO with CLCN7 mutations, 1...
Ulcerative colitis (UC) is a refractory chronic disease characterized by bloody diarrhea and mucosal or submucosal ulcers. There an urgent need of new drugs for the treatment ulcerative colitis. EHLJ7 quaternary coptisine derivative. Herein, we explored therapeutic effect on dextran sodium sulfate (DSS)-induced in mice. Results showed that have good effects DSS-induced significantly improved symptoms induced DSS including weight loss, colon contracture, activity index (DAI), inflammatory...
Subclinical hypothyroidism (SCH) has a high global prevalence. Most SCH patients have mild cases (thyrotropin ≤10 mIU/L). Treatment recommendations for are controversial, which raises concerns about the natural history of SCH. We aimed to clarify This is prospective population-based study. measured thyroid function in 11,000 participants REACTION study and followed 505 newly diagnosed aged 40-years or older between 2011 2014. Logistic regression analysis was used seek baseline parameters...
ABSTRACT Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) tumor. Previous studies have revealed generalized mineralization defects and low areal bone mineral density (aBMD) in TIO. However, data on the microarchitecture TIO are limited. In this study, we evaluated peripheral (distal radius tibia) axial (lumbar spine) skeleton using high-resolution quantitative computed tomography (HR-pQCT) trabecular...
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Abstract Context Nearly 20% patients with tumor-induced osteomalacia (TIO) experienced recurrence or nonrecovery after surgery. Serum fibroblast growth factor 23 and phosphate concentrations are not sufficient for prognosis in such cases. Despite its importance understanding of underlying pathogenesis, the alteration systemic metabolism refractory TIO remains unclear. Objective We aimed to find metabolomic characteristics establish a novel predictive model early discriminating based on their...
ABSTRACT In children and adolescents, distinguishing tumor-induced rickets/osteomalacia (TIR/O) from hereditary hypophosphatemic (HR/O) is a medical challenge. We retrospectively studied 10 Chinese adolescents with TIR/O who underwent surgery at mean age of 17.4 ± 2.1 years compared their characteristics to 24 age- sex-matched patients X-linked hypophosphatemia (XLH). Positive family history HR/O dental problems, such as enamel hypoplasia abscess, were reported in 8 (33.3%) 5 (20.8%) XLX,...
Abstract Context Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) tumor. Hyperparathyroidism (HPT) including secondary HPT (SHPT) and tertiary (THPT) in TIO patients, which believed to be associated with phosphate supplementation, has not been well documented. Objectives To clarify the prevalence, clinical characteristics, risk factors for large cohort Chinese patients our hospital. Design, setting,...
Tumor-induced rickets/osteomalacia (TIR/O) severely impairs bone microarchitecture and strength. However, no study has described the microarchitectural quality of in adolescent patients with TIR/O. TIR/O affects more than inherited causes hypophosphatemia, most common form which is X-linked hypophosphatemia (XLH). Nevertheless, differences between XLH have never been clarified. Therefore, this study, we used high-resolution peripheral quantitative computed tomography to assess five Chinese...
Abstract Context Hereditary hypophosphatemic rickets (HR) consists of a group inherited hypophosphatemia due to mutations different genes, which need genetic analysis make differential diagnosis. Among them, autosomal recessive type 1 (ARHR1), caused by homozygous mutation dentin matrix protein (DMP1), is extremely rare, with only 30 reported patients. To date, there has been no case compound heterozygous DMP1 mutations. Objective report the first causing ARHR1 and confirm effect on protein....
Several studies have estimated daily intake of resistant starch (RS), but no investigated the relationship RS with mortality. We aimed to examine associations between and all-cause cause-specific Data from US National Health Nutrition Examination Survey (NHANES) 1999 2018 24-h dietary recall data was used in current study. The main exposure this study intake, outcome mortality status participants until December 31, 2019. multivariable Cox proportional hazards regression models were developed...
There are few studies on the relationship between photoperiod and melatonin cycle in amphibians. To elucidate role of photoperiodically modulated endogenous different tissues Dybowski's frog (Rana dybowskii), its serum, liver, whole brain, skin, eyeballs were collected under five photoperiods, daily variation concentration was determined via high-performance liquid chromatography. Compared with control group (12 L:12 D), increased photoperiods 0 L:24 D 6 L:18 peaked at 00:00 D. This trend...
Objective: To determine the efficacy of imaging patients in a state traction (“traction imaging”) for selection upper and lower vertebrae to undergo instrumentation (UIV LIV, respectively) correct moderate severe, rigid scoliosis. Methods: Twenty‐seven aged 11–21 years (average, 15.5 years) who had been treated at our institution scoliosis thoracic spine between 2004 2008 were retrospectively analyzed. All with third multiple hook‐screw rod system. Standardized radiographic measurements...
Abstract Both acromegaly and tumor‐induced osteomalacia (TIO) are rare diseases caused by an excess hormone secreted neuroendocrine neoplasms, which growth (GH) fibroblast factor 23 (FGF23), respectively. GH elevates phosphate reabsorption via the effect of insulin‐like 1 (IGF‐1), while FGF23 inhibits reduces serum level markedly. A patient who developed a typical appearance but was accompanied with height loss hypophosphatemia for 2 years visited our hospital. Laboratory investigations...
To investigate the expression of chondromodulin-1 (ChM-I) in human adult degenerative intervertebral disc (IVD) cells and relationship between ChM-I degeneration.Three degenerated specimens obtained from patients treatment disease March to April 2009 were used for cell culture. IVD was examined by RT-PCR Western blot. The effect basic fibroblast growth factor (bFGF) on assessed real-time PCR From October 2008 2009, 26 tissues surgical at different stage degeneration according MRI. Six...