A5047316003- Vitamin D Research Studies
- Bone health and osteoporosis research
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Vitamin C and Antioxidants Research
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Chronic Disease Management Strategies
- Bioactive natural compounds
- Retinoids in leukemia and cellular processes
- Nutrition and Health in Aging
- Acute Lymphoblastic Leukemia research
- Peroxisome Proliferator-Activated Receptors
- interferon and immune responses
- Family Caregiving in Mental Illness
- Vitamin K Research Studies
- Bone and Joint Diseases
- Dialysis and Renal Disease Management
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
Lanzhou University
2009-2025
First Hospital of Lanzhou University
2014-2025
Singapore General Hospital
2024
Few studies have investigated the epidemiological metabolic (dysfunction) associated with fatty liver disease (MAFLD) in China, especially among those type 2 diabetes. We recruited 3553 patients aged 18-75 years diabetes who underwent abdominal ultrasound and serum biochemical analyses. Patient information including demographic anthropometric parameters was also collected. Overall, 63.2% of diabetic had MAFLD. Among MAFLD patients, proportions lean, nonobese, obese were 23.1%, 75.7%, 24.3%,...
Abstract Background Osteoporotic fractures are a growing problem in an aging society. The association between body mass index (BMI) and osteoporotic varies by fracture site ethnicity. Limited knowledge exists regarding this native Chinese, particularly utilizing local databases as reference sources. Objective To investigate the BMI at different sites Chinese women. Methods Three thousand ninety-eight female patients with radiographic 3098 age- sex-matched healthy controls without were...
Subclinical hypothyroidism (SCH) has a high global prevalence. Most SCH patients have mild cases (thyrotropin ≤10 mIU/L). Treatment recommendations for are controversial, which raises concerns about the natural history of SCH. We aimed to clarify This is prospective population-based study. measured thyroid function in 11,000 participants REACTION study and followed 505 newly diagnosed aged 40-years or older between 2011 2014. Logistic regression analysis was used seek baseline parameters...
Matrine is a natural product extracted from the root of Sophora flavescens that has been shown to be promising alternative drug in different types cancer. Here, we aimed investigate antitumor effects matrine on human papillary thyroid cancer (PTC) and explore underlying molecular mechanisms. Our data demonstrated following findings. (a) The expression miR-182-5p was significantly upregulated PTC tissues cell lines. (b) inhibited induced apoptosis TCP-1 BCPAP cells dose-dependent manner. (c)...
Diabetes mellitus increases the risk of developing hypertension. The relationship between glycosylated hemoglobin A1c (HbA1c) level and incident hypertension remains controversial. This study examined associations baseline change in HbA1c over 3 years with non-diabetic individuals.This community-based cohort was conducted 2591 individuals aged 40-75 without or diabetes at baseline, who participated a longitudinal (REACTION) program. Questionnaires were administered during interviews,...
Background and objectives Deficiency of vitamin D has been associated with various health conditions. The purpose this study was to evaluate the associations between serum 25OHD concentration lipid profiles in Chinese individuals. Methods design Serum were obtained for a cross sectional sample 10100 individuals aged 40-75 years from Lanzhou city, which is located western China. Linear-by-linear association, partial correlation analysis multiple logistic regression used profiles. Results...
To explore the correlation of triglyceride-glucose product (TyG) index with chronic kidney disease (CKD) in elderly population Lanzhou (Gansu Province, China).From May to September, 2011, a total 3868 middleaged and individuals without CKD from 3 communities were selected as cohort study followed for an average 3.1 years (from June, 2014 August, 2015). After excluding those missing follow-up data, 3439 included analysis, who divided according quartile TyG into Q1 group (TyG≤8.47), Q2 (TyG...
Although vitamin D status and its inverse association with diabetes among White people have been recognized, little research on has well conducted in Chinese individuals based glucose tolerance.To compare the of aged 40-75 years tolerance status.Serum 25OHD was measured a cross-sectional sample 10 038 from Lanzhou city, which is located western China.People normal (NGT, n = 4744), prediabetes (n 2808) or 2486) were included study. The difference concentration between NGT not significant...
This study aims to examine whether low serum 25-hydroxyvitamin D [25(OH)D] concentrations are correlated with increased risk of incident type 2 diabetes (T2D) in a Chinese population. The present prospective cohort included 5,543 participants aged 40-75 y old and is free at baseline Lanzhou city, China. Serum 25(OH)D were measured. T2D incidence was defined based on obtained results from oral glucose tolerance tests or self-reported previous diagnosis by healthcare professionals. association...
Advancements in acute stroke management have led to improved mortality rates. However, remains a chronic lifelong condition and is one of the top three leading causes disability Singapore. Stroke typically commences an hospital for stabilisation, followed by inpatient rehabilitation outpatient rehabilitation. With trend towards early supported discharge patients, general practitioners (GPs) are crucial providing comprehensive evidence based post-stroke care, which includes treating...
Renin-angiotensin-aldosterone system (RAAS) inhibitors appear to benefit bone tissue in antihypertensive treatment. However, the association between RAAS and metabolism was inconsistent.
To explore the correlation of different glucose metabolism statues with chronic kidney disease (CKD) in middle-aged and elderly individuals Lanzhou.Based on baseline data REACTION Study Lanzhou area, we randomly sampled 10 038 residents aged 40-75 years 3 communities Lanzhou, who were classified into normal tolerance (NGT), impaired regulation (IGR) diabetes groups. The estimated glomerular filtration rate (eGFR) urinary albumin-to-creatinine ratio (ACR) used to assess renal function...
Vitamin D deficiency has been considered a risk factor for atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate the correlation between serum 25(OH)D concentration and ASCVD in Chinese, especially Type 2 diabetes mellitus (T2DM) patients.Based on "REACTION" conducted 2011, some 9,014 Lanzhou residents aged 40-75 years were followed from 2014 2016. A total 7,061 with complete data analyzed. Baseline population classified into four groups based quartiles....
Physical activity plays an important role in the prevention of diabetes.Walking,swimming,aerobics,yoga and other sports have positive impact on treatment diabetes.Studies confirmed that different influence diabetes.Clinicians should prescribe individual plan according to patients' conditions. Key words: Walking; Swimming; Aerobics ; Yoga; Diabetes mellitus
Objective To investigate the control status of glycosylated hemoglobin (HbA1c) in middle aged and elderly patients with type 2 diabetes mellitus (T2DM) Lanzhou communities analyze its influencing factors. Methods A total 1 120 individuals having diagnosed T2DM 40-75 years were selected. Questionnaire was conducted. Height, weight, blood pressure lipid examined. Body mass index (BMI) calculated. The analyzed. Results The HbA1c less than 7.0% 453 cases (40.4%, 453/1 120), more or...
To explore the association between depressive symptoms and risks of rapid decline in renal function chronic kidney disease (CKD) middle-aged elderly with normal function.The residents aged 40- 75 years eGFR≥60 mL·min-1·1.73 m-2 without proteinuria Lanzhou region, who participated "REACTION" study carried out 2011, were selected followed up 2014. A total 4961 individuals complete qualified data from two surveys included subsequent analysis. Based on PHQ-9 questionnaire scores, baseline...
Abstract Background Vitamin D, a fat-soluble vitamin, play protective role in the cardiovascular system. Increasing evidence has suggested that vitamin D deficiency is significant risk factor for atherosclerotic disease (ASCVD). The aim of present study was to investigate correlation between serum 25-hydroxyvitamin D[25(OH)D] and ASCVD Chinese, especially people with type 2 diabetes mellitus(T2DM). Methods Based on "REACTION" conducted 2011, 9014 residents aged 40 75 Lanzhou, Gansu province...
Objective To investigate the correlation of baseline serum 25(OH) D level with risk type 2 diabetes mellitus (T2DM) and blood glucose control in diabetic patients among middle-aged elderly individuals Chengguan District Lanzhou, Gansu Province. Residents aged 40 to 75 years Lanzhou were selected from REACTION study conducted 2011 had been followed up since 2014. A total 5044 subjects complete data two surveys analyzed. Participants divided into Q1, Q2, Q3, Q4 subgroups based on quartiles...