A5041280943- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Tryptophan and brain disorders
- Synthesis and Biological Evaluation
- Microbial Community Ecology and Physiology
- Physical Activity and Health
- RNA modifications and cancer
- Synthesis and biological activity
- Pharmaceutical and Antibiotic Environmental Impacts
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
- Water Treatment and Disinfection
- Quinazolinone synthesis and applications
- Plant-derived Lignans Synthesis and Bioactivity
- Melanoma and MAPK Pathways
- Water Resources and Sustainability
- Coral and Marine Ecosystems Studies
- Polyamine Metabolism and Applications
- Fungal Biology and Applications
- Microplastics and Plastic Pollution
Beijing Normal University
2023-2025
University of Toronto
2025
First Hospital of Lanzhou University
2021-2024
Taipei City University of Science and Technology
2024
National Taiwan Normal University
2020-2024
Lanzhou University
2021-2024
Nanjing University of Information Science and Technology
2023-2024
Jilin University
2018-2023
Kaohsiung Medical University
2011-2023
Xi'an Shiyou University
2023
Endolithic microbes in coral skeletons are known to be a nutrient source for the host. In addition aerobic endolithic algae and Cyanobacteria, which usually described various corals form green layer beneath tissues, anaerobic photoautotrophic sulfur bacteria (GSB) Prosthecochloris is dominant skeleton of Isopora palifera. However, due inherent challenges studying skeleton, reason its niche preference function largely unknown.This study characterized diverse dynamic community shaped by...
Soil heavy metal(loid)s contamination caused by rapid urbanization and industrialization seriously affects human health hinders the global sustainable development goals (SDGs). Currently, there is a lack of comprehensive risk assessment (HHRA) studies for multiple land use types at regional scale. We propose practical framework that integrates empirical Bayesian kriging (EBK), pollution level analyses, modified HHRA modeling. The concentrations copper industry-related metals (Cu, Ni, Cd, As,...
The 6-methoxy-1,2,3,4-tetrahydroquinoline moiety in prior leads 2-chloro- and 2-methyl-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)quinazoline (1a 1b) was modified to produce 4-(N-cycloamino)quinazolines (4a–c 5a–m). new compounds were evaluated cytotoxicity tubulin inhibition assays, resulting the discovery of tubulin-polymerization inhibitors. 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin- 2(1H)-one (5f), most potent compound, exhibited high vitro cytotoxic activity (GI50...
To address the conceptual ambiguity surrounding climate carrying capacity and lack of a unified quantitative assessment method, here we integrate existing concepts propose comprehensive evaluation framework for capacity, emphasizing threshold system’s to support human activities. Additionally, incorporates carbon resource production potential, wind solar potential as its four key components, employs vector modeling approach quantitatively evaluate temporal spatial variations in across...
Abstract Epigenetic regulation is important for cancer progression; however, the underlying mechanisms, particularly those involving protein acetylation, remain to be fully understood. Here, we show that p300/ CBP ‐associated factor ( PCAF )‐dependent acetylation of transcription intestine‐specific homeobox ISX ) regulates epithelial–mesenchymal transition EMT and promotes metastasis. Mechanistically, at lysine 69 interaction with acetylated bromodomain‐containing 4 BRD 4) 332 in tumor...
Abstract Background Falls among older adults are a serious public health problem. Many studies indicate that positive functional fitness performance decreases the risk of falls. A limited amount previous study has investigated association between broad and fall risk. This examines associations falling community-dwelling adults. Methods Three waves cross-sectional data were collected from 2017 to 2019 in Taipei City, Taiwan. Six hundred sixty-five participants aged ≥65 years randomly...
Metastasis is the main cause of cancer mortality. However, triggering mechanisms and regulation epithelial-mesenchymal transition (EMT) factors in commitment metastasis have not been well characterized. Spermatogenic Zip 1 (SPZ1) acts as a proto-oncogene an upstream regulator EMT during tumorigenesis. Here we report that HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues SPZ1 positions 369 374, TWIST1 73 76, which are required for...
Abstract The intestine-specific homeobox transcription factor (ISX) is an IL6-inducible proto-oncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are undefined. In study, we provide evidence that ISX mediates a positive feedback loop integrating inflammation, tryptophan catabolism, and immune suppression. We found ISX-mediated IL6-induced expression catabolic enzymes Indoleamine 2,3-dioxygenase 1 (IDO1) carcinoma cells,...
Soil microbial communities play a vital role in the growth of invasive plants. Invasive species may shape peculiar functional microbes rhizosphere soil an to benefit its growth.
Acute lymphoblastic leukaemia (ALL) is the most prevalent cancer in children, and excessive iron buildup resulting from blood transfusions chemotherapy potentially has a negative impact on treatment outcomes prognosis patients with ALL. Therefore, initiating early chelation therapy during ALL logical approach. Ideally, selected chelator should also possess anti-leukaemia properties. The aim of present study was to explore potential underlying mechanism deferasirox (DFX) therapy. This proved...
Abstract Chronic inflammation drives initiation of hepatocellular carcinoma (HCC), but the underlying mechanisms linking and tumor formation remain obscure. In this study, we compared expression interleukin (IL)-6 cyclin D1 (CCND1) with IL-6–induced homeobox gene ISX (intestine-specific homeobox) in 119 paired specimens HCCs adjacent normal tissues also from 11 patients non-HCCs. pathologic analysis, exhibited a tumor-specific pattern high correlation to patient survival time, size, number,...
// Li-Ting Wang 1 , Jing-Ping Liou 2 Yu-Hsuan Li Yi-Min Liu Shiow-Lin Pan 3,* and Che-Ming Teng 1,* Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, School Pharmacy, Taipei Medical 3 The Ph.D. Program for Cancer Biology Drug Discovery, Science Technology, * These authors contributed equally to this work Correspondence: Pan, email: Teng, Keywords : MPT0G030, PKCδ, E-cadherin, HDAC, differentiation Received May 16, 2014 Accepted June 30, Published July...
// Li-Ting Wang 1 , Shyh-Shin Chiou 2, 3 Chee-Yin Chai 4 Edward Hsi 5 Shen-Nien 1, 6, 7 Shau-Ku Huang 8, 9 Shih-Hsien Hsu 9, 10 Graduate Institute of Medicine, College Kaohsiung Medical University, 807, Taiwan 2 Department Pediatrics, Faculty Division Hematology-Oncology, University Hospital, Pathology, Genome 6 Hepatobiliary Surgery, faculty 8 Environmental Health and Occupational National Research Institutes, Zhunan 115, Center for Infectious Disease Cancer (CICAR), Correspondence to: Hsu,...
We propose that beyond its role in WNT secretion, WLS/GPR177 (wntless, ligand secretion mediator) acts as an essential regulator controlling protein glycosylation, endoplasmic reticulum (ER) homeostasis, and dendritic cell (DC)-mediated immunity. WLS deficiency bone marrow-derived DCs (BMDCs) resulted poor growth inability to mount cytokine T-cell responses vitro, phenotypes were irreversible by the addition of exogenous WNTs. In fact, was discovered integrate a complex N-glycan-dependent...