A5103107644- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Analytical Chemistry and Sensors
- Nanoplatforms for cancer theranostics
- Quantum Dots Synthesis And Properties
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- Lanthanide and Transition Metal Complexes
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Characterization and Applications of Magnetic Nanoparticles
- Neuroscience and Neuropharmacology Research
- Chalcogenide Semiconductor Thin Films
- Laser-Ablation Synthesis of Nanoparticles
- Photoacoustic and Ultrasonic Imaging
- Molecular Sensors and Ion Detection
- Connective tissue disorders research
- Nanopore and Nanochannel Transport Studies
- Advanced Drug Delivery Systems
- Block Copolymer Self-Assembly
University of Toronto
2015-2025
Urmia University
2024
Urmia University of Medical Sciences
2024
3M (United States)
2017
Toronto Public Health
2017
Philipps University of Marburg
2009-2012
Manganese dioxide (MnO 2 ) nanoparticles (NPs) were discovered in previous work to be effective improving tumor oxygenation (hypoxia) and reducing H O acidity the microenvironment (TME) via local injection. To develop MnO formulations useful for clinical application, hybrid NPs are designed with tailored hydrophobicity structure suitable intravenous injection, good blood circulation, biocompatibility, high accumulation, programmable oxygen generation rate. Two different constructed by...
For imaging with different modalities, labels, which provide contrast for all are required. Colloidal nanoparticles composed out of an inorganic core and a polymer shell offer progress in this direction. Both, the shell, can be synthesized to fluorescent, magnetic, or radioactive. When cores combined shells, types particles dual obtained, as example, fluorescent radioactive shells. Properties perspectives such multimodal discussed.
Multiplexed detection of analytes is a challenge for numerous medical and biochemical applications. Many fluorescent particulate devices are being developed as ratiometric optical sensors to measure the concentration intracellular analytes. The response these based on changes emission intensity analyte-sensitive probes, entrapped into carrier system, which depends specific analyte. However, there series technical limits that prevent their use quantitative several in parallel (e.g., crosstalk...
Magnetic and NMR relaxivity properties of γ-Fe2O3 nanoparticles embedded into the walls polyelectrolyte multilayer capsules freely dispersed in a sodium borate buffer solution have been investigated. The different geometric distribution both configurations provides opportunity to study relationship water accessibility magnetic particles on relaxivity. Changes their blocking temperature average dipolar field were modeled as function packing fraction ensemble free entrapped nanoparticles. For...
We report about the synthesis of II−VI semiconductor nanocrystals (NCs) that grow in discrete steps. CdS, CdTe, ZnSe, and ZnO NCs were synthesized analogy to a method we recently developed for discontinuous growth CdSe NCs. Because similar conditions, these different materials can be directly compared. Also, CdS with Hg impurities showed growth. From all materials, could isolate fractions sizes via size-selective precipitation characterize their optical structural properties.
Abstract Micrometer‐sized polyelectrolyte capsules are synthesized, which have ion‐sensitive fluorophores embedded in their cavities. As the membranes of permeable to ions, fluorescence changed with ion concentration. In particular, sensitive protons, sodium, potassium, and chloride ions fabricated response analyzed. order allow for ratiometric measurements, additional whose emission do not depend on concentration emit a different wavelength co‐embedded capsule
Stable nanoformulations of diruthenium(<sc>ii</sc>,<sc>iii</sc>)-NSAID metallodrugs encapsulated in intravenously injectable polymer-lipid NPs have been prepared and tested cancer cells.
Multiplexed measurements of several analytes in parallel using analyte-sensitive organic fluorophores can be hampered by spectral overlap the different fluorophores. The authors discuss how nanoparticles help to overcome this problem. First, separated spatially confining them separate containers, each bearing a nanoparticle-based barcode. Second, coupling with fluorescence lifetimes that serve as donors for excitation transfer, effective lifetime acceptors tuned resonance energy transfer...
Abstract Here we report for the first time design and expression of highly charged, unfolded protein polymers based on elastin‐like peptides (ELPs). Positively negatively charged variants were achieved by introducing lysine glutamic acid residues, respectively, within repetitive pentapeptide units. Subsequently it was demonstrated that monodisperse polyelectrolytes with precisely defined amino compositions, sequences, stereochemistries can be transferred into superstructures exploiting their...
Abstract Multidrug resistance (MDR) is a main cause of chemotherapy failure in cancer treatment. It associated with complex cellular and molecular mechanisms including overexpression drug efflux transporters, increased membrane rigidity, impaired apoptosis. Numerous efforts have been made to overcome transporter‐mediated MDR using nanotechnology‐based approaches. However, these approaches fail surmount plasma rigidity that attenuates penetration nanoparticle endocytosis. Here, “one‐two...
The Layer-by-Layer fabrication of polyelectrolyte capsules with and without Au nanoparticles embedded into their walls is reported. We have studied the behaviour these under microwave irradiation. Their properties been investigated by transmission electron microscopy dynamic light scattering measurements. demonstrate that microwaves affect structure both types inducing remarkable damage to multilayer wall. also show upon exposure which are modified undergo rapid compared incorporated...
Successful delivery of anticancer drugs to intracellular targets requires different properties the nanocarrier overcome multiple transport barriers. However, few systems, date, possess such properties, despite knowledge about biological fate inorganic and polymeric nanocarriers in relation their fixed size, shape surface properties. Herein, a polymer-lipid hybrid nanoparticle (PLN) system is described with size transformability its mechanisms cellular uptake trafficking are...