A5005477804- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Polymer Surface Interaction Studies
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Quantum Dots Synthesis And Properties
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Advanced Fluorescence Microscopy Techniques
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Adsorption and biosorption for pollutant removal
- Tissue Engineering and Regenerative Medicine
- Electrochemical Analysis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Laser-Ablation Synthesis of Nanoparticles
- Carbon and Quantum Dots Applications
- Environmental remediation with nanomaterials
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Nanomaterials in Catalysis
- Lysosomal Storage Disorders Research
Universitat Pompeu Fabra
2016-2025
Barcelona Biomedical Research Park
2021-2025
Institut de Recerca en Energia de Catalunya
2022
Universitat Rovira i Virgili
2014-2016
Institut de Ciència de Materials de Barcelona
2016
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016
Philipps University of Marburg
2008-2015
Freie Universität Berlin
2007-2010
Ghent University
2009
To study charge-dependent interactions of nanoparticles (NPs) with biological media and NP uptake by cells, colloidal gold were modified amphiphilic polymers to obtain NPs identical physical properties except for the sign charge (negative/positive). This strategy enabled us solely assess influence on proteins without interference other effects such as different size stability. Our shows that number adsorbed human serum albumin molecules per was not influenced their surface charge. Positively...
We report a procedure to prepare highly monodisperse copper telluride nanocubes, nanoplates, and nanorods. The is based on the reaction of salt with trioctylphosphine in presence lithium bis(trimethylsilyl)amide oleylamine. CuTe nanocrystals display strong near-infrared optical absorption associated localized surface plasmon resonances. exploit this resonance for design surface-enhanced Raman scattering sensors unconventional probes. Furthermore, we also here our preliminary analysis use as...
Nanomaterials offer opportunities to construct novel compounds for many different fields. Applications include devices energy, including solar cells, batteries, and fuel health, contrast agents mediators photodynamic therapy hyperthermia. Despite these promising applications, any new class of materials also bears a potential risk human health the environment. The advantages innovations must be thoroughly compared against risks evaluate each nanomaterial. Although nanomaterials are often used...
Nanotoxicology is still a new discipline. In this Perspective, both its origins and future trends are discussed. particular, we note several issues consider important for publications in field.
Multilayer polyelectrolyte capsules made by layer-by-layer assembly of oppositely charged biodegradable polyelectrolytes were filled with a model nonactive prodrug, self-quenched fluorescence-labeled protein. After capsule uptake living cells, the walls actively degraded and digested intracellular proteases. Upon wall degradation, proteases could reach protein cargo in cavity capsules. Enzymatic fragmentation led to individual peptides thus revoked self-quenching dye. In this way...
Polyelectrolyte multilayer (PEM) capsules are carrier vehicles with great potential for biomedical applications. With the future aim of designing biocompatible, effective therapeutic delivery systems (e.g., cancer), pathway internalization (uptake and fate) PEM was investigated. In particular following experiments were performed: (i) study capsule co-localization established endocytic markers, (ii) switching-off endocytotic pathways pharmaceutical/chemical inhibitors, (iii) characterization...
A set of three types silver nanoparticles (Ag NPs) are prepared, which have the same Ag cores, but different surface chemistry. cores stabilized with mercaptoundecanoic acid (MUA) or a polymer shell [poly(isobutylene‐alt‐maleic anhydride) (PMA)]. In order to reduce cellular uptake, polymer‐coated NPs additionally modified polyethylene glycol (PEG). Corrosion (oxidation) is quantified and their colloidal stability investigated. MUA‐coated much lower than PMA‐coated largely agglomerated. All...
What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein-coated gold NPs were used to study physicochemical properties extra- intracellular fluids. These potential vehicles for enzymatic drug delivery highly stable at pH 7.4 presence salts free proteins, but agglomerated reversibly under acidic conditions (see picture). As a service our authors readers, this journal provides supporting information supplied...
Abstract: Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive of chemotherapeutic into cancer cells. The GQDs served fluorescent carriers well-known anticancer drug, doxorubicin (Dox). whole has capacity simultaneous tracking carrier and release. Dox release is triggered upon acidification intracellular vesicles, where are located after their uptake by Further functionalization loaded with targeting moieties such...
Abstract Time-resolved quantitative colocalization analysis is a method based on confocal fluorescence microscopy allowing for sophisticated characterization of nanomaterials with respect to their intracellular trafficking. This technique was applied relate the internalization patterns nanoparticles i . e superparamagnetic iron oxide distinct physicochemical characteristics uptake mechanism, rate and fate. The showed particles approximately same size shape as well similar magnetic...
The influence of graphene quantum dots (GQDs) on key characteristics bone marrow derived mesenchymal stem cells (MSCs) phenotype (i.e., self‐renewal, differentiation potential, and pluripotency) is systematically investigated in this work. First, the viability impact GQDs self‐renewal potential MSCs evaluated order to determine a threshold for exposing dose. Second, uptake by confirmed due excellent fluorescent properties particles. They exhibit homogenous cytoplasmatic distribution that...
Abstract The concept of a long‐term sensor for ion changes in the lysosome is presented. made by layer‐by‐layer assembly oppositely charged polyelectrolytes around ion‐sensitive fluorophores, this case protons. spontaneously incorporated cells and resides over days lysosome. Intracellular concentration protons upon cellular stimulation with pH‐active agents are monitored read‐out fluorescence at real time. With help it demonstrated that different used (Monensin, Chloroquine, Bafilomycin A1,...
An optical sensor was developed for the quantitative determination of intracellular nitric oxide. The consists plasmonic nanoprobes that have a coating mesoporous silica and an inner gold island film functionalized with chemoreceptor NO.