A5024418359- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Microbial Inactivation Methods
- Nanopore and Nanochannel Transport Studies
- Pneumonia and Respiratory Infections
- Microfluidic and Bio-sensing Technologies
- Seed and Plant Biochemistry
- Bacterial Infections and Vaccines
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Influenza Virus Research Studies
- Food composition and properties
- Microbial Metabolites in Food Biotechnology
- Nanoparticle-Based Drug Delivery
Princess Margaret Cancer Centre
2024
University Health Network
2024
University of Toronto
2013-2021
Successful delivery of anticancer drugs to intracellular targets requires different properties the nanocarrier overcome multiple transport barriers. However, few systems, date, possess such properties, despite knowledge about biological fate inorganic and polymeric nanocarriers in relation their fixed size, shape surface properties. Herein, a polymer-lipid hybrid nanoparticle (PLN) system is described with size transformability its mechanisms cellular uptake trafficking are...
Efficient, facile gene modification of cells has become an indispensable part modern molecular biology. For the majority cell lines and several primary populations, such modifications can be readily performed through a variety methods. However, many as stem frequently suffer from poor transfection efficiency. Though physical approaches have been introduced to circumvent these issues, they often require expensive/specialized equipment and/or consumables, utilize substantial numbers still...
Abstract Aberrant regulation of programmed cell death (PCD) has been tied to an array human pathologies ranging from cancers autoimmune disorders diverse forms neurodegeneration. Pharmacologic modulation PCD signalling is therefore central interest a number clinical and biomedical applications. A key component involves the pro‐ anti‐apoptotic Bcl‐2 family members. Among these, Bax translocation represents critical regulatory phase in PCD. In present study, we have employed high‐content...