A5100708925- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Alzheimer's disease research and treatments
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- DNA and Nucleic Acid Chemistry
- Advanced Drug Delivery Systems
- Bioactive natural compounds
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Advancements in Transdermal Drug Delivery
- Bioactive Compounds and Antitumor Agents
- Photodynamic Therapy Research Studies
- S100 Proteins and Annexins
- Nanopore and Nanochannel Transport Studies
- Diverse Scientific Research Studies
- Radiopharmaceutical Chemistry and Applications
- Bee Products Chemical Analysis
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Botanical Research and Applications
University of Toronto
2016-2024
Harvard University
2023
University Gastroenterology
2023
Brigham and Women's Hospital
2023
Koch Institute for Integrative Cancer Research At MIT
2023
Massachusetts Institute of Technology
2023
Jahangirnagar University
1970-2018
University of Waterloo
2013-2018
3M (United States)
2017
Toronto Public Health
2017
Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or combination, response to remains poor due hypoxic immunosuppressive nature tumor microenvironment. Herein, we exploited bioreactivity novel polymer–lipid manganese dioxide nanoparticles (PLMDs) remodel immune microenvironment (TIME) by increasing local oxygen levels extracellular pH enhancing radiation-induced immunogenic cell death. This study...
Finding effective disease-modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing the loss neural function. The current study demonstrates a new strategy, using multitargeted bioactive nanoparticles modify brain microenvironment achieve therapeutic benefits in well-characterized mouse model disease. application brain-penetrating manganese dioxide significantly reduces hypoxia, neuroinflammation, and oxidative stress; ultimately reducing levels...
Introduction Polymer-lipid hybrid nanoparticle (PLN) is an emerging nanoplatform with distinct properties and functionalities from other nanocarrier systems. PLN can be optimized to overcome various levels of drug delivery barriers achieve desired therapeutic outcomes via rational selection polymer lipid combinations based on a thorough understanding their interactions agents biological
Stable nanoformulations of diruthenium(<sc>ii</sc>,<sc>iii</sc>)-NSAID metallodrugs encapsulated in intravenously injectable polymer-lipid NPs have been prepared and tested cancer cells.
Abstract Therapeutic antibodies (e.g., trastuzumab, TRA) against human epidermal growth factor receptor 2 (HER2)‐positive breast cancers have shown benefits in controlling primary tumors, yet are ineffective brain metastases due to their inability cross the blood‐brain barrier (BBB). A novel hybrid nanoconstruct system is designed deliver trastuzumab metastasis of HER2‐positive cancer via a two‐step sequential targeting approach. Self‐assembly polysorbate 80 (PS 80)‐containing polymer,...
Successful delivery of anticancer drugs to intracellular targets requires different properties the nanocarrier overcome multiple transport barriers. However, few systems, date, possess such properties, despite knowledge about biological fate inorganic and polymeric nanocarriers in relation their fixed size, shape surface properties. Herein, a polymer-lipid hybrid nanoparticle (PLN) system is described with size transformability its mechanisms cellular uptake trafficking are...
Plant-derived phytochemicals consisting of phenols and flavonoids possess antioxidant properties, eventually rendering a lucrative tool to scavenge reactive oxygen species. This study was carried out evaluate in vitro cytotoxic potential methanolic extract petroleum ether extracts Smilax zeylanica L. stems.Phytochemical screening done following standard procedures. Antioxidant activity tested using several assays, viz., 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, NO H2O2 CUPRAC FRAP assay...
Objective: The current study aimed to develop a matrix type sustained release Diclofenac tablet, using hydrophilic hydroxypropyl methylcellulose (HPMC) and hydrophobic polymer cetyl alcohol (CA). Materials Methods: Two different polymers, that is, Methocel K15MCR ® CA were used in various proportions as controlling factor. Matrix tablets prepared by wet granulation technique. physicochemical properties of the granules evaluated. In vitro dissolution studies tablet patent product Voltaren SR...
Strategies to evaluate antioxidant and cytotoxic activity of pet ether extract Artocarpus chama Buch. seedTaksim Ahmed, Mohammad Nasir Uddin, Md. Kamal Hossain, Imamul Islam, Nizam Ehsanul Haque Mazumder
Michelia champaca (Magnoliaceae) is a large medicinal plant which traditionally used against number of diseases including inflammatory conditions. In the present study crude methanol extract M. leaf was investigated for possible antioxidant, analgesic and cytotoxic activity. The showed remarkable antioxidant activity in DPPH radical scavenging activity, nitric oxide total capacity assays. both NO assay, exhibited strong IC50 values assays were found to be 30.07 μg/ml 15.42 μg/ml,...
Chitosans are naturally occurring biologically safe and non-toxic polymer of polysaccharides. In the present study, Chitosan [(1-4) 2-amino-2-deoxy-β-D-glucan] was extracted from exoskeleton Black Tiger (Penaeus monodon) shrimp shells by alkaline deacetylation chitin. Three different chitosan extracts, coded as Chito A (3.33% w/w), B (4.01% w/w) C (3.45% were using 3%, 4% 5% w/v concentrations HCl decalcifiers respectively. Physicochemical properties such appearance, odor, insolubility pH...
Background This study was designed to evaluate the free radical scavenging property of chloroform extract bark Stereospermum chelonoides (SCBC) and investigate its potential in Alzheimer's disease inflammation, two oxidative stress related disorders. Methods Preliminary phytochemical analysis vitro antioxidant SCBC were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, ferric reducing power (FRAP) cupric capacity (CUPRAC) total determination assay. Total phenol flavonoid contents...
Antioxidant potential of the 80% methanol extract leaves Opuntia dillenii was evaluated using 1, 1-diphenyl, 2-picryl hydrazyl (DPPH) and nitric oxide radical scavenging, reducing power, total phenol flavonoid content determination assays. Preliminary phytochemical screening also carried out, which revealed that possesses flavonoids, steroids, alkaloids tannins. The showed significant antioxidant activities in all assays compared to reference a dose dependent manner. In DPPH scavenging...