A5103038578- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Advanced Optical Imaging Technologies
- Photodynamic Therapy Research Studies
- Tumors and Oncological Cases
- Dental Implant Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Advanced Vision and Imaging
- Quinazolinone synthesis and applications
- Periodontal Regeneration and Treatments
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Oral and gingival health research
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- dental development and anomalies
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Digital Holography and Microscopy
- Peptidase Inhibition and Analysis
- Head and Neck Surgical Oncology
- NF-κB Signaling Pathways
- Virtual Reality Applications and Impacts
Wonkwang University
2012-2025
Samsung (South Korea)
2010-2015
Ajou University
2014
Daejeon University
2012
Chosun University
2005-2011
Swedish Medical Center
2009-2010
American Association of Endodontists
2010
Kwangwoon University
2007-2008
Yonsei University
2000
The feasibility of identifying cancer cells by measuring the refractive index (RI) distribution across a single live cell with ultrahigh resolution full-field optical coherence microscopy (FF-OCM) is presented. FF-OCM utilized to quantify integral RI distributions unmodified without any treatments and used as biophysical indicator for diagnosing malignancy. Firstly, physical thickness adherent culture dish measured taking series 0.6 µm resolved en-face tomograms. Subsequently, from image...
Toll-like receptors (TLRs) orchestrate a repertoire of immune responses in macrophages against various pathogens. Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans are two important periodontal In the present study, we investigated TLR signaling regulating cytokine production response to F. A. actinomycetemcomitans. TLR2 TLR4 redundant cytokines (interleukin-6 [IL-6] tumor necrosis factor alpha [TNF-α]) nucleatum- actinomycetemcomitans-infected macrophages. The by infection...
To enhance the ability of indirubin derivatives to inhibit CDK2/cyclin E, a target anticancer agents, we designed and synthesized new series indirubin-3′-oxime with combined substitutions at 5 5′ positions. A molecular docking study predicted binding OH or halogen position ATP site CDK2, revealing critical interactions that may explain improved CDK2 inhibitory activity these derivatives. Among derivatives, 5-nitro-5′-hydroxy analogue 3a 5-nitro-5′-fluoro 5a displayed potent against IC50...
A simple bone cyst (SBC) is a non-neoplastic intraosseous cavity without an epithelial lining. It usually asymptomatic and has little effect on the surrounding structures. SBC associated with root resorption of involved tooth seldom been reported. 63-year-old Korean woman was referred to our hospital for cystic lesion left mandibular second molar. Radiographic examination revealed well-demarcated radiolucent severe in tooth. The extracted, surgical exploration empty only small amount fibrous...
Abstract Purpose: The novel indirubin derivatives 5′-nitro-indirubinoxime, 5′-fluoro-indirubinoxime, and 5′-trimethylacetamino-indirubinoxime were designed tested for antitumor activity both in vitro vivo using rat tumor model. Experimental Design: Three-week-old male Sprague-Dawley rats inoculated s.c. on the left flank with 107 RK3E-ras kidney epithelial cells harboring k-ras gene. Alternatively, 5 × 106 injected into oral mucosa. Indirubin derivative treatment began 3rd or 6th day after...
Even though there are many types of methods to generate CGH (computer-generated hologram) patterns three-dimensional (3D) objects, most them have been applied still images but not video due their computational complexity in applications 3D holograms. A new method for fast computation is proposed by combined use data compression and lookup table techniques. Temporally redundant the removed with differential pulse code modulation (DPCM) algorithm, then these compressed videos generated novel...
J Oral Pathol Med (2012) 41 : 540–546 Background: Toll‐like receptor (TLR) agonists have anticancer effect by inducing apoptosis or activating immune cells. In this study, we investigated whether imiquimod, TLR7 agonist, inhibits the proliferation of oral cancer Methods: 7 expression and IL‐6/8 production imiquimod were examined using RT‐PCR Enzyme‐linked immunosorbent assay, respectively. Cell viability was MTT assay. To examine apoptotic cell death, Annexin V/PI staining for flow cytometry...
Background The overexpression of histone deacetylases ( HDAC s) has been observed in many cancers, and inhibition specific s emerged as a new target for cancer therapy. We found that 7 expression was selectively reduced by inhibitor apicidin salivary mucoepidermoid carcinoma MEC ) cells. Here, we show suppression potent antitumor effect Methods Histone deacetylases7 knocked down using si RNA s, cell proliferation quantified. Cell cycle progression, apoptosis, autophagy were measured flow...
Epigenetic inactivation of tumor suppressor genes is common in human cancer. Using a large-scale whole-genome approach an earlier study, the authors identified epigenetically silenced with potential function glioblastoma (GBM). Three this analysis-DKK1, SFRP1, and WIF1-are potent inhibitors Wnt signal transduction pathway. Here, confirm decreased expression these GBM tissue samples relative to nontumor brain using real-time PCR. They then show that all 3 restored T98 cells by treatment...
Pheophorbide a (Pa) is chlorine-based photosensitizer derived from an ethnopharmacological herb, and our group recently synthesized Pa by the removal of magnesium ion phytyl chlorophyll-a. In this study, effect photodynamic therapy (PDT) with was examined in human oral squamous cell carcinoma (OSCC) cells.Cells were treated PDT Pa, reactive oxygen species (ROS) mitochondrial membrane potential [ΔΨ (m)] examined. Apoptosis measured using annexin V staining immunoblot. Autophagy characterized...
Glycogen synthase kinase-3β (GSK-3β) plays an important role in the regulation of apoptosis. To investigate its involvement acquired cadmium (Cd) resistance, Cd-resistant cells (RH460) were established from H460 lung carcinoma cells. Cd resistance led to interruption apoptosis and autophagy, as determined by apoptotic sub-G1 population, procaspase-3 clevage, LC3-II induction. Cd-induced autophagy preceded 3-methyladenine or zVAD time-course experiments after treatment. Despite β-catenin...
There is growing interest in the use of cuttlefish bone (CB) as a graft material. Silicon (Si) plays an important role formation and calcification. This study aimed to prepare Si-substituted CB-derived hydroxyapatite (Si-CB-HAp) using natural CB improve bioactivity for formation.We prepared Si-HAp from hydrothermal solvothermal method. The microstructure chemical composition were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), energy dispersive spectrometer...
Photodynamic therapy (PDT) has been recommended as an alternative for various diseases including microbial infection. Recently, we developed a new method the preparation of highly pure chlorin e6 (Ce6), which widely used second-generation photosensitizer. PDT using Ce6 was very effective inhibition in vitro growth several bacterial strains. To clarify possibility its clinical application, this study, examined and vivo antimicrobial effects Ce6-mediated mice model skin infection...