A5069399932- Cancer Immunotherapy and Biomarkers
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Proteoglycans and glycosaminoglycans research
- PARP inhibition in cancer therapy
- RNA Interference and Gene Delivery
- Oral microbiology and periodontitis research
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Proteins in Food Systems
- Cell Adhesion Molecules Research
- Light effects on plants
- Lung Cancer Research Studies
- Microencapsulation and Drying Processes
- Coronary Interventions and Diagnostics
- Advanced Breast Cancer Therapies
- Clusterin in disease pathology
- Nanoparticles: synthesis and applications
- Viral Infectious Diseases and Gene Expression in Insects
- Iron oxide chemistry and applications
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Cancer Treatment and Pharmacology
University of Toronto
2021-2024
King Abdulaziz City for Science and Technology
2016-2024
Life Science Institute
2018
Studying the interactions of nanoparticles (NPs) with serum proteins is necessary for rational development nanocarriers. Optimum surface chemistry a key consideration to modulate formation protein corona (PC) and resultant immune response. We investigated constituent PC formed by hyaluronic acid-coated chitosan NPs (HA-CS NPs). Non-decorated (CS NPs) alginate-coated (Alg-CS were utilized as controls. Results show that HA modifications significantly reduced adsorption relative Gene Ontology...
The aim of the present study was to determine effect different cryoprotectants and their concentration on physicochemical characteristics chitosan nanoparticles (CS-NPs). coating CS-NPs with hyaluronic acid (HA) alginic (ALG) before after lyophilization also evaluated. ionic gelation method used for preparation NPs six types (sucrose, glucose, trehalose, mannitol, polyethylene glycol-2000, glycol-10,000) were investigated at 5%, 10%, 20%, 50% levels. Coating HA protection high amount...
Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or combination, response to remains poor due hypoxic immunosuppressive nature tumor microenvironment. Herein, we exploited bioreactivity novel polymer–lipid manganese dioxide nanoparticles (PLMDs) remodel immune microenvironment (TIME) by increasing local oxygen levels extracellular pH enhancing radiation-induced immunogenic cell death. This study...
In recent years, nanotechnology has been proven to offer promising biomedical applications for <italic>in vivo</italic> diagnostics and drug delivery, stressing the importance of thoroughly investigating biocompatibility potentially translatable nanoparticles (NPs).
Radiotherapy (RT) is one of major therapeutic modalities in combating breast cancer. In RT, ionizing radiation employed to induce DNA double-strand breaks (DSBs) as a primary mechanism that causes cancer cell death. However, the induced damage can also trigger activation repair mechanisms, reducing efficacy RT treatment. Given pivotal role RAD50 protein radiation-responsive pathways involving DSBs, we developed novel polymer-lipid based nanoparticle formulation containing RAD50-silencing RNA...
Abstract Triple negative breast cancer (TNBC) has a poor prognosis due to its aggressive nature, high incidence of distant metastasis, and lack targets for effective therapy. Therefore, novel multifunctional biopolymer‐anticancer drug combination nanomedicine is designed the prevention spontaneous metastasis while treating primary TNBC. Oligomeric hyaluronic acid (oHA) doxorubicin (DOX) at synergistic ratio against TNBC cells are co‐loaded in polymer‐lipid hybrid nanoparticle (PLN) which...
Abstract Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype. Despite the early response to chemotherapy, high incidence of recurrence leads short overall survival and poor prognosis. Native hyaluronic acid (HA) interacts with CD44 receptors for hyaluronan mediated motility (RHAMM) overexpressed in TNBC mediating chemo-resistance metastasis. In contrast, oligomeric HA (oHA) can disrupt HA-CD44/RHAMM interactions attenuate oncogenic pro-metastatic pathways, such as...
Abstract Background: Metastatic triple-negative breast cancer (TNBC), especially with BRCA1/2 mutations, is a deadly subtype of ~12% 5-year survival. Despite their FDA approval, the therapeutic benefits poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) are limited to mutated malignancies. Moreover, PARPi olaparib has been shown upregulate expression programmed death-ligand 1 (PD-L1) leading immune suppression. The purpose this study investigate if novel nanoparticle...