A5077878309- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Reproductive Biology and Fertility
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Microfluidic and Capillary Electrophoresis Applications
- Neuroscience and Neural Engineering
- Micro and Nano Robotics
- Image Processing Techniques and Applications
- Sperm and Testicular Function
- Piezoelectric Actuators and Control
- Advanced Sensor and Energy Harvesting Materials
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Carbon Nanotubes in Composites
- Electrospun Nanofibers in Biomedical Applications
- Graphene research and applications
- Nanowire Synthesis and Applications
- Nanofabrication and Lithography Techniques
- Cell Image Analysis Techniques
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
University of Toronto
2016-2025
Huazhong University of Science and Technology
2006-2025
Anhui University of Science and Technology
2020-2025
Guangdong Provincial People's Hospital
2025
Jinan University
2025
Northeast Institute of Geography and Agroecology
2023-2025
Chinese Academy of Sciences
2008-2025
Northeast Normal University
2019-2025
Beijing Friendship Hospital
2025
Union Hospital
2025
Abstract Autofocusing is a fundamental technology for automated biological and biomedical analyses indispensable routine use of microscopes on large scale. This article presents comprehensive comparison study 18 focus algorithms in which total 139,000 microscope images were analyzed. Six samples used with three observation methods (brightfield, phase contrast, differential interference contrast (DIC)) under two magnifications (100× 400×). A ranking methodology proposed, based the are ranked....
Mechanical forces play important roles in the regulation of various biological processes at molecular and cellular level, such as gene expression, adhesion, migration, cell fate, which are essential to maintenance tissue homeostasis. In this review, we discuss emerging bioengineered tools enabled by microscale technologies for studying mechanical biology. addition traditional mechanobiology experimental techniques, review recent advances microelectromechanical systems (MEMS)-based approaches...
This paper reports an electrostatic microelectromechanical systems (MEMS) gripper with integrated capacitive force sensor. The sensitivity is more than three orders of magnitude higher other monolithically fabricated MEMS grippers feedback. sensing resolution provides feedback in the range forces that dominate micromanipulation process. A ultrasonic device described for aligning microobjects suspended water using fields. alignment particles a sufficient accuracy microgripper must only return...
As mechanical end-effectors, microgrippers enable the pick–transport–place of micrometer-sized objects, such as manipulation and positioning biological cells in an aqueous environment. This paper reports on a monolithic MEMS-based microgripper with integrated force feedback along two axes presents first demonstration force- controlled micro-grasping at nanonewton level. The system manipulates highly deformable biomaterials (porcine interstitial cells) environment using that integrates V-beam...
Abstract Real‐time and continuous monitoring of physiological signals is essential for mobile health, which becoming a popular tool efficient convenient medical services. Here, an active pulse sensing system that can detect the weak vibration patterns human radial artery constructed with sandwich‐structure piezoelectret has high equivalent piezoelectricity. The precision stability result in possible assessment applications, including capability to identify common heart problems (such as...
The study of nuclear mechanical properties can provide insights into dynamics and its role in cellular mechanotransduction. While several methods have been developed to characterize properties, direct intracellular probing the nucleus situ is challenging. Here, a modified AFM (atomic force microscopy) needle penetration technique demonstrated mechanically cell nuclei situ. Cytoplasmic stiffness were determined based on two different segments indentation curves correlated with simultaneous...
Inspired by the collective intelligence in natural swarms, microrobotic agents have been controlled to form artificial swarms for targeted drug delivery, enhanced imaging, and hyperthermia. Different from these well-investigated tasks, this work aims develop embolization, which is a clinical technique used block blood vessels treating tumors, fistulas, arteriovenous malformations. Magnetic particle were formed selective embolization address low selectivity of present that prone cause...
Abstract Understanding biological systems and mimicking their functions require electronic tools that can interact with tissues matched softness. These involve biointerfacing materials should concurrently match the softness of tissue exhibit suitable electrical conductivities for recording reading bioelectronic signals. However, commonly employed intrinsically soft stretchable usually contain solvents limit stability long-term use or possess low conductivity. To date, an ultrasoft (i.e.,...
Previous intracytoplasmic sperm injection (ICSI) studies have indicated significant variation in ICSI success rates among different species. In mouse ICSI, the zona pellucida (ZP) undergoes a "hardening" process at fertilization order to prevent subsequent from penetrating. There been few investigating changes mechanical properties of ZP post fertilization. To characterize and quantitate property differences before after fertilization, microelectromechanical systems-based multiaxis cellular...
Recent advances in microbiology, such as cloning, demonstrate that increasingly complex micromanipulation strategies are required for manipulating individual biological cells. In this paper, we present a microrobotic system capable of conducting automatic embryo pronuclei DNA injection (cell injection). Conventionally, cell has been conducted manually, however, long training, low success rates from poor reproducibility manual operations, and contamination all call the elimination direct...
As an important embodiment of biomanipulation, injection foreign materials (e.g., DNA, RNAi, sperm, protein, and drug compounds) into individual cells has significant implications in genetics, transgenics, assisted reproduction, discovery. This paper presents a microrobotic system for fully automated zebrafish embryo injection, which overcomes the problems inherent manual operation, such as human fatigue large variations success rates due to poor reproducibility. Based on computer vision...
Carbon nanotubes (CNTs) have shown great promise as sensing elements in nanoelectromechanical sensors. In this review paper, we discuss the electrical, mechanical, and electromechanical properties of CNTs that are used such applications. This investigation indicates which nanotube should be carefully considered when designing nanotube-based We then present primary techniques been for integration into devices proceed to give a description sensors developed using active
This paper presents a microfluidic system for cell type classification using mechanical and electrical measurements on single cells. Cells are aspirated continuously through constriction channel with elongations impedance profiles measured simultaneously. The transit time the amplitude ratio quantified as cell's property indicators. device measurement were used to characterize osteoblasts (n = 206) osteocytes 217), revealing that osteoblasts, compared osteocytes, have larger elongation...
This paper presents a robotic system that is capable of both picking up and releasing microobjects with high accuracy, reliability, speed. Due to force-scaling laws, large adhesion forces at the microscale make rapid, accurate release long-standing challenge in micromanipulation, thus representing hurdle toward automated pick-and-place micrometer-sized objects. The employs novel microelectromechanical systems (MEMS) microgripper controllable plunging structure impact microobject gains...