A5020048073- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Modular Robots and Swarm Intelligence
- Cerebrospinal fluid and hydrocephalus
- Micro and Nano Robotics
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Inspired by the collective intelligence in natural swarms, microrobotic agents have been controlled to form artificial swarms for targeted drug delivery, enhanced imaging, and hyperthermia. Different from these well-investigated tasks, this work aims develop embolization, which is a clinical technique used block blood vessels treating tumors, fistulas, arteriovenous malformations. Magnetic particle were formed selective embolization address low selectivity of present that prone cause...
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance blood-based early cancer detection. However, integrative profiling cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequencing method for comprehensive analysis genome-wide methylation, fragmentation, copy number alteration (CNA) characteristics enhanced We apply this to plasma samples 497 healthy controls 780 patients seven types...
Abstract Plasma cell-free DNA (cfDNA) methylation and fragmentation signatures have been shown to be valid biomarkers for blood-based cancer detection. However, conventional sequencing assays are inapplicable fragmentomic profiling due bisulfite-induced damage. Here using enzymatic conversion-based low-pass whole-methylome (WMS), we developed a novel approach comprehensively interrogate the genome-wide plasma methylation, fragmentation, copy number profiles sensitive noninvasive multi-cancer...