A5037984313- Neuroscience and Neuropharmacology Research
- HER2/EGFR in Cancer Research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Cell Adhesion Molecules Research
- Spine and Intervertebral Disc Pathology
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- NF-κB Signaling Pathways
- Musculoskeletal pain and rehabilitation
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Medicinal plant effects and applications
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- Multiple Myeloma Research and Treatments
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2015-2024
United States Food and Drug Administration
2011-2024
Zhejiang University
2015-2024
Center for Drug Evaluation and Research
2011-2024
Quality Research
2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Zhejiang Chinese Medical University
2024
Soochow University
2024
Stanford University
2016-2021
ROS deficiency promotes proinflammatory T cells in rheumatoid arthritis.
Alcohol use disorders (AUDs) constitute the most common form of substance abuse. The development AUDs involves repeated alcohol leading to tolerance, withdrawal syndrome, and physical psychological dependence, with loss ability control excessive drinking. Currently there is no effective therapeutic agent for without major side effects. Dihydromyricetin (DHM; 1 mg/kg, i.p. injection), a flavonoid component herbal medicines, counteracted acute (EtOH) intoxication, also signs in rats including...
Treatment with trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of Human Epidermal Growth Factor Receptor 2 (HER2), very successfully improves outcomes for women HER2-positive breast cancer. However, trastuzumab treatment was recently linked to potentially irreversible serious cardiotoxicity, mechanisms which are largely elusive. This study reports that significantly alters expression myocardial genes essential DNA repair, cardiac and mitochondrial...
Abstract Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading synapse dysfunction in Alzheimer’s disease (AD). In the present study, we report that probability (Pr) at between Schaffer collateral (SC) and CA1 pyramidal neurons significantly reduced an stage mouse models of AD with elevated Aβ production. High nanomolar synthetic oligomeric 42 also suppresses Pr SC-CA1 wild-type mice. This Aβ-induced suppression mainly due...
Microvascular endothelial cells in the arterial adventitia have immunoregulatory function and build an instructive tissue niche for induction of pathogenic T giant cell arteritis.
Abstract Dysregulation of autophagy has been implicated in various cardiovascular diseases. Trastuzumab, a humanized monoclonal antibody, binds to HER2 domain IV and is approved for the treatment HER2-positive breast cancer. Trastuzumab therapy associated with considerable cardiotoxicity, mechanism which remains unclear. signaling plays pivotal role cardiomyocyte development survival essential prevention cardiomyopathy. However, direct link not confirmed between trastuzumab-induced...
Astrocytes are critical in synapse development, and their dysfunction crucial developmental stages leads to serious neurodevelopmental diseases, including seizures epilepsy. Immune challenges not only affect brain but also promote seizure generation epileptogenesis, implying immune activation is one of the key factors linking epilepsy abnormal development. In this study, we report that activating astrocytes by systemic lipopolysaccharide (LPS) second postnatal week promotes excitatory...
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
Abstract Metabolites in the tumor microenvironment are a critical factor for progression. However, lack of knowledge about metabolic profile bone marrow (BM) multiple myeloma (MM) limits our understanding MM Here, we show that glycine concentration BM is elevated due to collagen degradation mediated by cell-secreted matrix metallopeptidase 13 (MMP13), while level linked cells utilize channel protein solute carrier family 6 member 9 (SLC6A9) absorb extrinsic subsequently involved synthesis...
Immature bone marrow–derived myeloid dendritic cells (BMDCs) are induced to undergo phenotypic maturation and secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-12, IL-10 when pulsed in vitro with intact Streptococcus pneumoniae. After transfer naive mice, BMDCs induce immunoglobulin (Ig) isotype responses specific for both protein polysaccharide pneumococcal antigens, having common the requirement viable BMDCs, T cells, B7-dependent costimulation recipient mice. Whereas...
Abstract Although treatment with trastuzumab improves outcomes for women ErbB2-positive breast cancer, many patients who achieve an initial response to subsequently acquire resistance within 1 year. Rac1, a Ras-like small GTPase, has been implicated in the control of cell growth and morphology is believed be associated cancer progression metastasis. Here, we show that when parental SKBR3 cells become resistant trastuzumab, Rac1 activity increased, leading altered morphology, which...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There thus an urgent unmet clinical need develop effective anticancer drugs treat pancreatic cancer. Here, we study potential repurposing monensin as drug for chemo-resistant Using two commonly-used cancer cell lines PANC-1 MiaPaCa-2, show that suppresses proliferation migration, cycle progression, while solicits...
Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into multiple lineages including osteoblastic lineage. Osteogenic differentiation of MSCs is a cascade recapitulates most, if not all, the molecular events occurring during embryonic skeletal development, which regulated by numerous signaling pathways bone morphogenetic proteins (BMPs). Through comprehensive analysis osteogenic activity, we previously demonstrated BMP9 most potent BMP for inducing formation from...
Foraging food in a novel environment is essential for survival. Animals coordinate the complex motivated states and decide whether to initiate feeding or escape from unfamiliar scenes. Neurons paraventricular thalamic nucleus (PVT) receive multiple inputs hypothalamus, forebrain, caudal brainstem that are known regulate behavior. The PVT neurons also project forebrain regions involved reward motivation. Notably, projecting accumbens (NAc) activated when an incentive stimulus presented....
Summary The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown that bortezomib (BTZ) resistance associated with an increase the SSP myeloma (MM) cells; however, underlying mechanisms of SSP‐induced BTZ remain unclear. In this study, we found phosphoglycerate dehydrogenase (PHGDH), first rate‐limiting enzyme SSP, was significantly elevated CD138 + cells derived from patients relapsed MM. Moreover, high PHGDH conferred inferior survival We also...
Abstract Rheumatoid arthritis (RA) and psoriatic (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show CD4 + T cells from patients RA PsA have increased expression of the pore-forming calcium channel component ORAI3, thereby increasing activity arachidonic acid-regulated calcium-selective (ARC) making sensitive to acid. A similar increase does not occur in systemic lupus erythematosus. Increased ORAI3 transcription is caused by reduced...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2-positive metastatic breast cancer. It consists trastuzumab, a humanized mAb directed against HER2, and microtubule inhibitor, DM1, conjugated to trastuzumab via thioether linker. Hepatotoxicity one serious adverse events associated with T-DM1 therapy. Mechanisms underlying T-DM1-induced hepatotoxicity remain elusive. Here, we use hepatocytes mouse models investigate mechanisms...