A5043847043- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Lipoproteins and Cardiovascular Health
- Protease and Inhibitor Mechanisms
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Mitochondrial Function and Pathology
- Cytomegalovirus and herpesvirus research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Heart Failure Treatment and Management
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Immunotherapy and Immune Responses
Medical University of Vienna
2016-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2019-2024
Ludwig Boltzmann Institute for Cancer Research
2019-2023
Ludwig Boltzmann Cluster for Cardiovascular Research
2006-2021
Wilhelminen Hospital
2007-2017
Universität für Weiterbildung Krems
2017
Stanford University
2011-2016
KU Leuven
2009-2013
VIB-KU Leuven Center for Cancer Biology
2013
Boehringer Ingelheim (Austria)
2011
Angiogenesis is a common feature observed in advanced atherosclerotic lesions. We hypothesized that oxidized phospholipids (OxPLs), which accumulate vessels can stimulate angiogenesis. found 1-palmitoyl-2-arachidonoyl- sn -glycero-3-phosphocholine (OxPAPC) stimulated the formation of sprouts from endothelial cell spheroids and promoted growth capillaries into Matrigel plugs mice. OxPLs expression vascular factor (VEGF) vivo several normal tumor types vitro. In addition, OxPAPC upregulated...
Macrophages are immune cells, capable to remodel the extracellular matrix, which can harbor DNA incorporated into neutrophil traps (NETs). To study breakdown of NETs we studied capability macrophage subsets degrade these structures in vitro and vivo a murine thrombosis model. Furthermore, analyzed human abdominal aortic aneurysm samples support our results. Approach Results: were seeded onto blood clots or isolated polarized. All macrophages NETs. For initial breakdown, relied on...
BACKGROUND: Venous thromboembolism is a major health problem. After thrombus formation, its resolution essential to re-establish blood flow, which crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets endothelial cells. Thus, we aimed modulate leukocyte function during post-thrombus formation blocking P-selectin/CD62P-mediated cell interactions. METHODS: Thrombosis was induced inferior vena cava stenosis through ligation mice. 1 day,...
AimsApoptosis plays an important role in the progression of heart failure (HF). The purpose this study was to assess whether pro-apoptotic molecules apoptosis-stimulating fragment (FAS, CD95/APO-1) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) predict event-free survival HF patients.
Autophagy allows cells fundamental adaptations to metabolic needs and stress. Using autophagic bulk degradation can clear crosslinked macromolecules damaged organelles that arise under redox Accumulation of such debris results in cellular dysfunction is observed aged tissue senescent cells. Conversely, promising anti-aging strategies aim at inhibiting the mTOR pathway thereby activating autophagy, counteract aging associated damage. We have inactivated autophagy related 7 (Atg7), an...
Abstract Human monocytes are a heterogeneous cell population, which can be divided into classical (CD14++CD16−), non-classical (CD14+CD16+) and an intermediate (CD14++CD16+) subset. We hypothesized that low-grade inflammation may differentially affect monocyte subsets. used human lipopolysaccharide (LPS) infusion model to mimic identify, subsets preferentially activated under these conditions. Monocyte were identified by staining for CD14 CD16, activation status of was analyzed CD11b novel...
Despite underlying pathologies leading to ICU admittance are heterogeneous, many patients develop a systemic inflammatory response syndrome often in the absence of microbial pathogens. Mitochondrial DNA that shows similarities bacterial may be released after tissue damage and activates innate immune system by binding toll-like receptor-9 on cells. The aim this study was analyze whether levels mitochondrial associated with 30-day survival predictive value is modified expression its receptor...
It is believed that adipose tissue acts as an endocrine organ by producing inflammatory mediators and thereby contributes to the increased cardiovascular risk seen in obesity. A link between mass angiogenesis has been suggested. Vascular endothelial growth factor (VEGF) seems be implicated this process. Members of glycoprotein (gp)130 ligand family regulate VEGF expression other cells.We used explants well primary cultures preadipocytes adipocytes from human subcutaneous visceral investigate...
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A B), leading to deficient factor VIII IX proteins, respectively. Hemophilia-related complications into joints (the hallmark of hemophilia) and age-related comorbidities occur frequently impact functionality quality life persons with hemophilia (PwH). Given chronic nature hemophilia, we hypothesized that has an association accelerated biological aging. Therefore, investigated aging...
Cardiac diseases such as myocardial infarction and heart failure are among the leading causes of death in western societies. Therapeutic angiogenesis has been suggested a concept to combat these diseases. The biology angiogenic factors expressed vascular endothelial growth factor (VEGF) is well studied, whereas data on anti-angiogenic mediators scarce. Here we study expression pigment epithelium-derived (PEDF) human cardiac cells. PEDF could be detected tissue protein mRNA levels. levels...
<h3>Objective</h3> To assess the prognostic value of mitogenic, antiapoptotic, angiogenic and antifibrotic hepatocyte growth factor (HGF) in heart failure (HF). <h3>Design</h3> Prospective cohort study. <h3>Setting/patients</h3> Assessment HGF levels at inclusion 351 patients with advanced HF (median 75 years, interquartile range (IQR) 63–82, 66% male). <h3>Main outcome measures</h3> All-cause mortality, cardiovascular mortality. <h3>Results</h3> During a median follow-up 16 months, 26%...
Immunological processes are implicated in the multifactorial pathophysiology of heart failure (HF). The multifunctional chemokine fractalkine (CX3CL1) promotes extravasation cytotoxic lymphocytes into tissues. We aimed to assess prognostic value HF. Fractalkine plasma levels were determined 349 patients with advanced systolic HF (median 75 years, 66% male). During a median follow-up 4.9 years (interquartile range: 4.6-5.2), 55.9% died. was significant predictor all-cause mortality (p<0.001)...
Obesity is considered to be a major comorbidity. Obese patients suffer from an increased proinflammatory state associated with premature aging phenotype including secretion of senescence-associated secretory proteins (SASP) and reduced telomere length. Micro-ribonucleic acids (miRNAs) are non-coding RNA molecules that could modify the post-transcriptional process. Several studies have reported associations between miRNAs metabolic unhealthy conditions.To determine if bariatric surgery...